skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Frontier methods in coherent X-ray diffraction for high-resolution structure determination

Abstract

Abstract In 1912, Max von Laue and collaborators first observed diffraction spots from a millimeter-sized crystal of copper sulfate using an X-ray tube. Crystallography was born of this experiment, and since then, diffraction by both X-rays and electrons has revealed a myriad of inorganic and organic structures, including structures of complex protein assemblies. Advancements in X-ray sources have spurred a revolution in structure determination, facilitated by the development of new methods. This review explores some of the frontier methods that are shaping the future of X-ray diffraction, including coherent diffractive imaging, serial femtosecond X-ray crystallography and small-angle X-ray scattering. Collectively, these methods expand the current limits of structure determination in biological systems across multiple length and time scales.

Authors:
; ;
Publication Date:
Research Org.:
Univ. of California, Los Angeles, CA (United States)
Sponsoring Org.:
USDOE Office of Science (SC)
OSTI Identifier:
1534402
DOE Contract Number:  
SC0010378
Resource Type:
Journal Article
Journal Name:
Quarterly Reviews of Biophysics
Additional Journal Information:
Journal Volume: 49; Journal ID: ISSN 0033-5835
Publisher:
Cambridge University Press
Country of Publication:
United States
Language:
English
Subject:
Biophysics

Citation Formats

Gallagher-Jones, Marcus, Rodriguez, Jose A., and Miao, Jianwei. Frontier methods in coherent X-ray diffraction for high-resolution structure determination. United States: N. p., 2016. Web. doi:10.1017/s0033583516000147.
Gallagher-Jones, Marcus, Rodriguez, Jose A., & Miao, Jianwei. Frontier methods in coherent X-ray diffraction for high-resolution structure determination. United States. doi:10.1017/s0033583516000147.
Gallagher-Jones, Marcus, Rodriguez, Jose A., and Miao, Jianwei. Fri . "Frontier methods in coherent X-ray diffraction for high-resolution structure determination". United States. doi:10.1017/s0033583516000147.
@article{osti_1534402,
title = {Frontier methods in coherent X-ray diffraction for high-resolution structure determination},
author = {Gallagher-Jones, Marcus and Rodriguez, Jose A. and Miao, Jianwei},
abstractNote = {Abstract In 1912, Max von Laue and collaborators first observed diffraction spots from a millimeter-sized crystal of copper sulfate using an X-ray tube. Crystallography was born of this experiment, and since then, diffraction by both X-rays and electrons has revealed a myriad of inorganic and organic structures, including structures of complex protein assemblies. Advancements in X-ray sources have spurred a revolution in structure determination, facilitated by the development of new methods. This review explores some of the frontier methods that are shaping the future of X-ray diffraction, including coherent diffractive imaging, serial femtosecond X-ray crystallography and small-angle X-ray scattering. Collectively, these methods expand the current limits of structure determination in biological systems across multiple length and time scales.},
doi = {10.1017/s0033583516000147},
journal = {Quarterly Reviews of Biophysics},
issn = {0033-5835},
number = ,
volume = 49,
place = {United States},
year = {2016},
month = {1}
}