skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Stimulation of synaptoneurosome glutamate release by monomeric and fibrillated α-synuclein: Fibrillated α-Syn Enhances Synaptic Glutamate

Abstract

Not provided.

Authors:
 [1];  [1];  [1];  [1];  [2];  [3];  [1];  [1]
  1. Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, UCLA, Los Angeles CA USA
  2. Brain Research Institute, UCLA, Los Angeles CA USA
  3. Department of Chemistry and Biochemistry, UCLA, Los Angeles CA USA
Publication Date:
Research Org.:
Univ. of California, Los Angeles, CA (United States)
Sponsoring Org.:
USDOE Office of Science (SC)
OSTI Identifier:
1533184
DOE Contract Number:  
FC02-02ER63421
Resource Type:
Journal Article
Journal Name:
Journal of Neuroscience Research
Additional Journal Information:
Journal Volume: 95; Journal Issue: 9; Journal ID: ISSN 0360-4012
Publisher:
Wiley
Country of Publication:
United States
Language:
English
Subject:
Neurosciences & Neurology

Citation Formats

Sarafian, Theodore A., Littlejohn, Kaitlyn, Yuan, Sarah, Fernandez, Charlene, Cilluffo, Marianne, Koo, Bon-Kyung, Whitelegge, Julian P., and Watson, Joseph B. Stimulation of synaptoneurosome glutamate release by monomeric and fibrillated α-synuclein: Fibrillated α-Syn Enhances Synaptic Glutamate. United States: N. p., 2017. Web. doi:10.1002/jnr.24024.
Sarafian, Theodore A., Littlejohn, Kaitlyn, Yuan, Sarah, Fernandez, Charlene, Cilluffo, Marianne, Koo, Bon-Kyung, Whitelegge, Julian P., & Watson, Joseph B. Stimulation of synaptoneurosome glutamate release by monomeric and fibrillated α-synuclein: Fibrillated α-Syn Enhances Synaptic Glutamate. United States. doi:10.1002/jnr.24024.
Sarafian, Theodore A., Littlejohn, Kaitlyn, Yuan, Sarah, Fernandez, Charlene, Cilluffo, Marianne, Koo, Bon-Kyung, Whitelegge, Julian P., and Watson, Joseph B. Tue . "Stimulation of synaptoneurosome glutamate release by monomeric and fibrillated α-synuclein: Fibrillated α-Syn Enhances Synaptic Glutamate". United States. doi:10.1002/jnr.24024.
@article{osti_1533184,
title = {Stimulation of synaptoneurosome glutamate release by monomeric and fibrillated α-synuclein: Fibrillated α-Syn Enhances Synaptic Glutamate},
author = {Sarafian, Theodore A. and Littlejohn, Kaitlyn and Yuan, Sarah and Fernandez, Charlene and Cilluffo, Marianne and Koo, Bon-Kyung and Whitelegge, Julian P. and Watson, Joseph B.},
abstractNote = {Not provided.},
doi = {10.1002/jnr.24024},
journal = {Journal of Neuroscience Research},
issn = {0360-4012},
number = 9,
volume = 95,
place = {United States},
year = {2017},
month = {1}
}

Works referenced in this record:

A further update on the role of excitotoxicity in the pathogenesis of Parkinson’s disease
journal, January 2014

  • Ambrosi, Giulia; Cerri, Silvia; Blandini, Fabio
  • Journal of Neural Transmission, Vol. 121, Issue 8
  • DOI: 10.1007/s00702-013-1149-z

Direct Observation of Amyloid Fibril Growth Monitored by Thioflavin T Fluorescence
journal, March 2003

  • Ban, Tadato; Hamada, Daizo; Hasegawa, Kazuhiro
  • Journal of Biological Chemistry, Vol. 278, Issue 19
  • DOI: 10.1074/jbc.C300049200

The effect of guanidine on transmitter release in the ciliary ganglion of the chick.
journal, May 1978


α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation
journal, August 2011

  • Bartels, Tim; Choi, Joanna G.; Selkoe, Dennis J.
  • Nature, Vol. 477, Issue 7362
  • DOI: 10.1038/nature10324

The Function of α-Synuclein
journal, September 2013


ANS Binding Reveals Common Features of Cytotoxic Amyloid Species
journal, June 2010

  • Bolognesi, Benedetta; Kumita, Janet R.; Barros, Teresa P.
  • ACS Chemical Biology, Vol. 5, Issue 8
  • DOI: 10.1021/cb1001203

Systematic Mutagenesis of  -Synuclein Reveals Distinct Sequence Requirements for Physiological and Pathological Activities
journal, October 2012


Definition of a Molecular Pathway Mediating  -Synuclein Neurotoxicity
journal, April 2015


 -Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro
journal, August 2010


Synaptoneurosome micromethod for fractionation of mouse and human brain, and primary neuronal cultures
journal, November 2012


Initiation and elongation in fibrillation of ALS-linked superoxide dismutase
journal, November 2008

  • Chattopadhyay, M.; Durazo, A.; Sohn, S. H.
  • Proceedings of the National Academy of Sciences, Vol. 105, Issue 48
  • DOI: 10.1073/pnas.0807058105

Membrane interactions and fibrillization of α-synuclein play an essential role in membrane disruption
journal, October 2014


Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation
journal, April 2015

  • Chen, Serene W.; Drakulic, Srdja; Deas, Emma
  • Proceedings of the National Academy of Sciences, Vol. 112, Issue 16
  • DOI: 10.1073/pnas.1421204112

Large  -synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking
journal, February 2013

  • Choi, B. -K.; Choi, M. -G.; Kim, J. -Y.
  • Proceedings of the National Academy of Sciences, Vol. 110, Issue 10
  • DOI: 10.1073/pnas.1218424110

Pitfalls associated with the use of Thioflavin-T to monitor anti-fibrillogenic activity
journal, July 2014

  • Coelho-Cerqueira, Eduardo; Pinheiro, Anderson S.; Follmer, Cristian
  • Bioorganic & Medicinal Chemistry Letters, Vol. 24, Issue 14
  • DOI: 10.1016/j.bmcl.2014.04.072

From Macroscopic Measurements to Microscopic Mechanisms of Protein Aggregation
journal, August 2012

  • Cohen, Samuel I. A.; Vendruscolo, Michele; Dobson, Christopher M.
  • Journal of Molecular Biology, Vol. 421, Issue 2-3
  • DOI: 10.1016/j.jmb.2012.02.031

Molecular Underpinnings of Synaptic Vesicle Pool Heterogeneity: Molecularly Distinct Synaptic Vesicle Pools
journal, March 2015

  • Crawford, Devon C.; Kavalali, Ege T.
  • Traffic, Vol. 16, Issue 4
  • DOI: 10.1111/tra.12262

Direct Observation of the Interconversion of Normal and Toxic Forms of α-Synuclein
journal, May 2012


Different Species of  -Synuclein Oligomers Induce Calcium Influx and Seeding
journal, August 2007


Parkinson's Disease
journal, September 2003


Structural Organization of α-Synuclein Fibrils Studied by Site-directed Spin Labeling
journal, June 2003

  • Der-Sarkissian, Ani; Jao, Christine C.; Chen, Jeannie
  • Journal of Biological Chemistry, Vol. 278, Issue 39
  • DOI: 10.1074/jbc.M305266200

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of  -synuclein
journal, July 2009

  • Desplats, P.; Lee, H. -J.; Bae, E. -J.
  • Proceedings of the National Academy of Sciences, Vol. 106, Issue 31
  • DOI: 10.1073/pnas.0903691106

KTKEGV repeat motifs are key mediators of normal α-synuclein tetramerization: Their mutation causes excess monomers and neurotoxicity
journal, July 2015

  • Dettmer, Ulf; Newman, Andrew J.; von Saucken, Victoria E.
  • Proceedings of the National Academy of Sciences, Vol. 112, Issue 31
  • DOI: 10.1073/pnas.1505953112

α-Synuclein Can Inhibit SNARE-Mediated Vesicle Fusion through Direct Interactions with Lipid Bilayers
journal, March 2013

  • DeWitt, David C.; Rhoades, Elizabeth
  • Biochemistry, Vol. 52, Issue 14
  • DOI: 10.1021/bi4002369

Excitatory amino acid transporters: Roles in glutamatergic neurotransmission
journal, July 2014


One-pot total chemical synthesis of human α-synuclein
journal, January 2013

  • Fauvet, Bruno; Butterfield, Sara M.; Fuks, Jonas
  • Chemical Communications, Vol. 49, Issue 81
  • DOI: 10.1039/c3cc45353g

Olfactory deficits in mice overexpressing human wildtype -synuclein
journal, July 2008


The Parkinson's disease protein  -synuclein disrupts cellular Rab homeostasis
journal, December 2007

  • Gitler, A. D.; Bevis, B. J.; Shorter, J.
  • Proceedings of the National Academy of Sciences, Vol. 105, Issue 1
  • DOI: 10.1073/pnas.0710685105

Role of α-synuclein in synaptic glutamate release
journal, October 2007

  • Gureviciene, Irina; Gurevicius, Kestutis; Tanila, Heikki
  • Neurobiology of Disease, Vol. 28, Issue 1
  • DOI: 10.1016/j.nbd.2007.06.016

The genetics and neuropathology of Parkinson’s disease
journal, July 2012


Targeted Amino-Terminal Acetylation of Recombinant Proteins in E. coli
journal, December 2010


Isolation and characterization of synaptoneurosomes from single rat hippocampal slices
journal, December 1997

  • Johnson, Michael W.; Chotiner, Jennifer K.; Watson, Joseph B.
  • Journal of Neuroscience Methods, Vol. 77, Issue 2
  • DOI: 10.1016/S0165-0270(97)00120-9

Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease
journal, April 2008

  • Kordower, Jeffrey H.; Chu, Yaping; Hauser, Robert A.
  • Nature Medicine, Vol. 14, Issue 5
  • DOI: 10.1038/nm1747

Towards a Pharmacophore for Amyloid
journal, June 2011


 -Synuclein Overexpression in PC12 and Chromaffin Cells Impairs Catecholamine Release by Interfering with a Late Step in Exocytosis
journal, November 2006


Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation
journal, April 2008

  • Li, Jia-Yi; Englund, Elisabet; Holton, Janice L.
  • Nature Medicine, Vol. 14, Issue 5
  • DOI: 10.1038/nm1746

α-Synuclein produces a long-lasting increase in neurotransmitter release
journal, October 2004


The Role of Stable α-Synuclein Oligomers in the Molecular Events Underlying Amyloid Formation
journal, February 2014

  • Lorenzen, Nikolai; Nielsen, Søren Bang; Buell, Alexander K.
  • Journal of the American Chemical Society, Vol. 136, Issue 10
  • DOI: 10.1021/ja411577t

Modeling Lewy pathology propagation in Parkinson's disease
journal, January 2014


Soluble, Prefibrillar α-Synuclein Oligomers Promote Complex I-dependent, Ca 2+ -induced Mitochondrial Dysfunction
journal, June 2014

  • Luth, Eric S.; Stavrovskaya, Irina G.; Bartels, Tim
  • Journal of Biological Chemistry, Vol. 289, Issue 31
  • DOI: 10.1074/jbc.M113.545749

Fibril growth and seeding capacity play key roles in α-synuclein-mediated apoptotic cell death
journal, July 2015

  • Mahul-Mellier, A-L; Vercruysse, F.; Maco, B.
  • Cell Death & Differentiation, Vol. 22, Issue 12
  • DOI: 10.1038/cdd.2015.79

GM1 Specifically Interacts with α-Synuclein and Inhibits Fibrillation
journal, February 2007

  • Martinez, Zak; Zhu, Min; Han, Shubo
  • Biochemistry, Vol. 46, Issue 7
  • DOI: 10.1021/bi061749a

Role of α-Synuclein Carboxy-Terminus on Fibril Formation in Vitro
journal, July 2003

  • Murray, Ian V. J.; Giasson, Benoit I.; Quinn, Shawn M.
  • Biochemistry, Vol. 42, Issue 28
  • DOI: 10.1021/bi027363r

Optical Reporters for the Conformation of  -Synuclein Reveal a Specific Interaction with Mitochondria
journal, November 2008


Astrocyte Calcium Signal and Gliotransmission in Human Brain Tissue
journal, May 2012


Progressive Aggregation of Alpha-Synuclein and Selective Degeneration of Lewy Inclusion-Bearing Neurons in a Mouse Model of Parkinsonism
journal, March 2015


Extracellular α-synuclein alters synaptic transmission in brain neurons by perforating the neuronal plasma membrane
journal, February 2015

  • Pacheco, Carla R.; Morales, Camila N.; Ramírez, Alejandra E.
  • Journal of Neurochemistry, Vol. 132, Issue 6
  • DOI: 10.1111/jnc.13060

High Stability and Cooperative Unfolding of α-Synuclein Oligomers
journal, September 2014

  • Paslawski, Wojciech; Andreasen, Maria; Nielsen, Søren Bang
  • Biochemistry, Vol. 53, Issue 39
  • DOI: 10.1021/bi5007833

α-Synuclein strains cause distinct synucleinopathies after local and systemic administration
journal, June 2015

  • Peelaerts, W.; Bousset, L.; Van der Perren, A.
  • Nature, Vol. 522, Issue 7556
  • DOI: 10.1038/nature14547

Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism
journal, August 2015

  • Prusiner, Stanley B.; Woerman, Amanda L.; Mordes, Daniel A.
  • Proceedings of the National Academy of Sciences, Vol. 112, Issue 38
  • DOI: 10.1073/pnas.1514475112

Seeking a Mechanism for the Toxicity of Oligomeric α-Synuclein
journal, March 2015


Differential neuropathological alterations in transgenic mice expressing ?-synuclein from the platelet-derived growth factor and Thy-1 promoters
journal, May 2002

  • Rockenstein, Edward; Mallory, Margaret; Hashimoto, Makoto
  • Journal of Neuroscience Research, Vol. 68, Issue 5
  • DOI: 10.1002/jnr.10231

Exogenous  -Synuclein Decreases Raft Partitioning of Cav2.2 Channels Inducing Dopamine Release
journal, August 2014


C-Terminal Turn Stability Determines Assembly Differences between Aβ40 and Aβ42
journal, January 2013

  • Roychaudhuri, Robin; Yang, Mingfeng; Deshpande, Atul
  • Journal of Molecular Biology, Vol. 425, Issue 2
  • DOI: 10.1016/j.jmb.2012.11.006

Impairment of Mitochondria in Adult Mouse Brain Overexpressing Predominantly Full-Length, N-Terminally Acetylated Human α-Synuclein
journal, May 2013


α‐synuclein assemblies sequester neuronal α3‐Na + /K +ATP ase and impair Na + gradient
journal, August 2015

  • Shrivastava, Amulya Nidhi; Redeker, Virginie; Fritz, Nicolas
  • The EMBO Journal, Vol. 34, Issue 19
  • DOI: 10.15252/embj.201591397

Parkinson's Disease: Genetics and Pathogenesis
journal, February 2011


Presynaptic Alpha-Synuclein Aggregation in a Mouse Model of Parkinson's Disease
journal, February 2014


αB Crystallin Is Apically Secreted within Exosomes by Polarized Human Retinal Pigment Epithelium and Provides Neuroprotection to Adjacent Cells
journal, October 2010


Function of the asparagine 74 residue of the inhibitory γ-subunit of retinal rod cGMP-phophodiesterase (PDE) in vivo
journal, October 2011


Role of α-synuclein penetration into the membrane in the mechanisms of oligomer pore formation: α-syn membrane penetration
journal, February 2012


Membrane Curvature Induction and Tubulation Are Common Features of Synucleins and Apolipoproteins
journal, August 2010

  • Varkey, Jobin; Isas, Jose Mario; Mizuno, Naoko
  • Journal of Biological Chemistry, Vol. 285, Issue 42
  • DOI: 10.1074/jbc.M110.139576

Structure, function and toxicity of alpha-synuclein: the Bermuda triangle in synucleinopathies
journal, September 2015

  • Villar-Piqué, Anna; Lopes da Fonseca, Tomás; Outeiro, Tiago Fleming
  • Journal of Neurochemistry, Vol. 139
  • DOI: 10.1111/jnc.13249

Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death
journal, October 2011


A soluble  -synuclein construct forms a dynamic tetramer
journal, October 2011

  • Wang, W.; Perovic, I.; Chittuluru, J.
  • Proceedings of the National Academy of Sciences, Vol. 108, Issue 43
  • DOI: 10.1073/pnas.1113260108

Alterations in corticostriatal synaptic plasticity in mice overexpressing human α-synuclein
journal, March 2009


Cytosolic Proteins Regulate α-Synuclein Dissociation from Presynaptic Membranes
journal, August 2006

  • Wislet-Gendebien, Sabine; D'Souza, Cheryl; Kawarai, Toshitaka
  • Journal of Biological Chemistry, Vol. 281, Issue 43
  • DOI: 10.1074/jbc.M605965200