Multifunctional Biomedical Imaging in Physiological and Pathological Conditions Using a NIR-II Probe
Abstract
Contrasted with imaging in the visible (400–650 nm) and near-infrared window I (NIR-I, 650–900 nm) regions, imaging in near-infrared window II (NIR-II, 1000–1700 nm) is a highly promising in vivo imaging modality with improved resolution and deeper tissue penetration. Here, a small molecule NIR-II dye,5,5'-(1H,5H-benzo[1,2-c:4,5-c'] bis[1,2,5]thiadiazole)-4,8-diyl)bis(N,N-bis(4-(3-((tert-butyldimethylsilyl)oxy)propyl)phenyl) thiophen-2-amine), is successfully encapsulated into phospholipid vesicles to prepare a probe CQS1000. The novel NIR-II probe is studied for in vivo multifunctional biological imaging. The results of this study indicate that the NIR-II vesicle CQS1000 can noninvasively and dynamically visualize and monitor many physiological and pathological conditions of circulatory systems, including lymphatic drainage and routing, angiogenesis of tumor, and vascular deformity such as arterial thrombus formation and ischemia with high spatial and temporal resolution. More importantly, by virtue of the favorable half-life of blood circulation of CQS1000, NIR-II imaging is capable of aiding precise resection of tumor such as osteosarcoma and accelerating the process of lymph node dissection to complete sentinel lymph node biopsy for better decision making during the tumor surgery. Overall, CQS1000 is a highly promising NIR-II probe for multifunctional biomedical imaging in physiological and pathological conditions, surpassing traditional NIR-I imaging modality and pathologic assessments for clinical diagnosis and treatment.
- Authors:
-
- Wuhan Univ. (China); Stanford Univ., CA (United States)
- Stanford Univ., CA (United States)
- Wuhan Univ. (China)
- Publication Date:
- Research Org.:
- Stanford Univ., CA (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC)
- OSTI Identifier:
- 1533019
- Alternate Identifier(s):
- OSTI ID: 1400851
- Grant/Contract Number:
- SC0008397
- Resource Type:
- Journal Article: Accepted Manuscript
- Journal Name:
- Advanced Functional Materials
- Additional Journal Information:
- Journal Volume: 27; Journal Issue: 23; Journal ID: ISSN 1616-301X
- Publisher:
- Wiley
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 36 MATERIALS SCIENCE; chemistry; science & technology; materials science; physics; fluorescence imaging; lymphatic system; NIR‐II probes; sentinel lymph nodes; tumors; vascular system
Citation Formats
Shou, Kangquan, Qu, Chunrong, Sun, Yao, Chen, Hao, Chen, Si, Zhang, Lei, Xu, Haibo, Hong, Xuechuan, Yu, Aixi, and Cheng, Zhen. Multifunctional Biomedical Imaging in Physiological and Pathological Conditions Using a NIR-II Probe. United States: N. p., 2017.
Web. doi:10.1002/adfm.201700995.
Shou, Kangquan, Qu, Chunrong, Sun, Yao, Chen, Hao, Chen, Si, Zhang, Lei, Xu, Haibo, Hong, Xuechuan, Yu, Aixi, & Cheng, Zhen. Multifunctional Biomedical Imaging in Physiological and Pathological Conditions Using a NIR-II Probe. United States. https://doi.org/10.1002/adfm.201700995
Shou, Kangquan, Qu, Chunrong, Sun, Yao, Chen, Hao, Chen, Si, Zhang, Lei, Xu, Haibo, Hong, Xuechuan, Yu, Aixi, and Cheng, Zhen. Mon .
"Multifunctional Biomedical Imaging in Physiological and Pathological Conditions Using a NIR-II Probe". United States. https://doi.org/10.1002/adfm.201700995. https://www.osti.gov/servlets/purl/1533019.
@article{osti_1533019,
title = {Multifunctional Biomedical Imaging in Physiological and Pathological Conditions Using a NIR-II Probe},
author = {Shou, Kangquan and Qu, Chunrong and Sun, Yao and Chen, Hao and Chen, Si and Zhang, Lei and Xu, Haibo and Hong, Xuechuan and Yu, Aixi and Cheng, Zhen},
abstractNote = {Contrasted with imaging in the visible (400–650 nm) and near-infrared window I (NIR-I, 650–900 nm) regions, imaging in near-infrared window II (NIR-II, 1000–1700 nm) is a highly promising in vivo imaging modality with improved resolution and deeper tissue penetration. Here, a small molecule NIR-II dye,5,5'-(1H,5H-benzo[1,2-c:4,5-c'] bis[1,2,5]thiadiazole)-4,8-diyl)bis(N,N-bis(4-(3-((tert-butyldimethylsilyl)oxy)propyl)phenyl) thiophen-2-amine), is successfully encapsulated into phospholipid vesicles to prepare a probe CQS1000. The novel NIR-II probe is studied for in vivo multifunctional biological imaging. The results of this study indicate that the NIR-II vesicle CQS1000 can noninvasively and dynamically visualize and monitor many physiological and pathological conditions of circulatory systems, including lymphatic drainage and routing, angiogenesis of tumor, and vascular deformity such as arterial thrombus formation and ischemia with high spatial and temporal resolution. More importantly, by virtue of the favorable half-life of blood circulation of CQS1000, NIR-II imaging is capable of aiding precise resection of tumor such as osteosarcoma and accelerating the process of lymph node dissection to complete sentinel lymph node biopsy for better decision making during the tumor surgery. Overall, CQS1000 is a highly promising NIR-II probe for multifunctional biomedical imaging in physiological and pathological conditions, surpassing traditional NIR-I imaging modality and pathologic assessments for clinical diagnosis and treatment.},
doi = {10.1002/adfm.201700995},
url = {https://www.osti.gov/biblio/1533019},
journal = {Advanced Functional Materials},
issn = {1616-301X},
number = 23,
volume = 27,
place = {United States},
year = {2017},
month = {4}
}
Web of Science
Works referenced in this record:
Carotid-Artery Intima and Media Thickness as a Risk Factor for Myocardial Infarction and Stroke in Older Adults
journal, January 1999
- O'Leary, Daniel H.; Polak, Joseph F.; Kronmal, Richard A.
- New England Journal of Medicine, Vol. 340, Issue 1
Indocyanine green-fluorescent imaging of hepatocellular carcinoma during laparoscopic hepatectomy: An initial experience
journal, February 2010
- Ishizawa, T.; Bandai, Y.; Harada, N.
- Asian Journal of Endoscopic Surgery, Vol. 3, Issue 1
A feasibility study (ICG-10) of indocyanine green (ICG) fluorescence mapping for sentinel lymph node detection in early breast cancer
journal, August 2012
- Wishart, G. C.; Loh, S. -W.; Jones, L.
- European Journal of Surgical Oncology (EJSO), Vol. 38, Issue 8
Three-dimensional imaging of single nanotube molecule endocytosis on plasmonic substrates
journal, January 2012
- Hong, Guosong; Wu, Justin Z.; Robinson, Joshua T.
- Nature Communications, Vol. 3, Issue 1
Image-guided cancer surgery using near-infrared fluorescence
journal, July 2013
- Vahrmeijer, Alexander L.; Hutteman, Merlijn; van der Vorst, Joost R.
- Nature Reviews Clinical Oncology, Vol. 10, Issue 9
Real-time identification of liver cancers by using indocyanine green fluorescent imaging
journal, June 2009
- Ishizawa, Takeaki; Fukushima, Noriyoshi; Shibahara, Junji
- Cancer, Vol. 115, Issue 11
Ag 2 Se Quantum Dots with Tunable Emission in the Second Near-Infrared Window
journal, February 2013
- Zhu, Chun-Nan; Jiang, Peng; Zhang, Zhi-Ling
- ACS Applied Materials & Interfaces, Vol. 5, Issue 4
Transplacental Carcinogenesis by Stilbestrol
journal, August 1971
- Folkman, Judah
- New England Journal of Medicine, Vol. 285, Issue 7
Rare-earth-doped biological composites as in vivo shortwave infrared reporters
journal, July 2013
- Naczynski, D. J.; Tan, M. C.; Zevon, M.
- Nature Communications, Vol. 4, Issue 1
Indocyanine Green and Lymphatic Imaging: Current Problems
journal, June 2010
- Gashev, Anatoliy A.; Nagai, Takashi; Bridenbaugh, Eric A.
- Lymphatic Research and Biology, Vol. 8, Issue 2
Microvascular Loops and Networks as Prognostic Indicators in Choroidal and Ciliary Body Melanomas
journal, February 1999
- Makitie, T.; Summanen, P.; Tarkkanen, A.
- JNCI Journal of the National Cancer Institute, Vol. 91, Issue 4
ICG Pulse Spectrophotometry for Perioperative Liver Function in Hepatectomy
journal, March 2002
- Okochi, Osamu; Kaneko, Tetsuya; Sugimoto, Hiroyuki
- Journal of Surgical Research, Vol. 103, Issue 1
Through-skull fluorescence imaging of the brain in a new near-infrared window
journal, August 2014
- Hong, Guosong; Diao, Shuo; Chang, Junlei
- Nature Photonics, Vol. 8, Issue 9
Nanoparticle therapeutics: an emerging treatment modality for cancer
journal, September 2008
- Davis, Mark E.; Chen, Zhuo; Shin, Dong M.
- Nature Reviews Drug Discovery, Vol. 7, Issue 9
MRI and Quantification of Draining Lymph Node Function in Inflammatory Arthritis
journal, November 2007
- Proulx, S. T.; Kwok, E.; You, Z.
- Annals of the New York Academy of Sciences, Vol. 1117, Issue 1
Radiopharmaceuticals in sentinel lymph-node detection – an overview
journal, March 1999
- Wilhelm, Abraham J.; Mijnhout, G. Sophie; Franssen, Eric J. F.
- European Journal of Nuclear Medicine, Vol. 26, Issue S1
Band Gap Fluorescence from Individual Single-Walled Carbon Nanotubes
journal, July 2002
- O'Connell, Michael J.; Bachilo, Sergei M.; Huffman, Chad B.
- Science, Vol. 297, Issue 5581, p. 593-596
Phase II trial of weekly nab (nanoparticle albumin-bound)-paclitaxel (nab-paclitaxel) (Abraxane(R)) in combination with gemcitabine in patients with metastatic breast cancer (N0531)
journal, October 2008
- Roy, V.; LaPlant, B. R.; Gross, G. G.
- Annals of Oncology, Vol. 20, Issue 3
Methods for generating families of univariate continuous distributions in the recent decades: Methods for generating families of univariate continuous distributions
journal, April 2013
- Lee, Carl; Famoye, Felix; Alzaatreh, Ayman Y.
- Wiley Interdisciplinary Reviews: Computational Statistics, Vol. 5, Issue 3
Intraoperative intravital microscopy permits the study of human tumour vessels
journal, February 2016
- Fisher, Daniel T.; Muhitch, Jason B.; Kim, Minhyung
- Nature Communications, Vol. 7, Issue 1
Ultrafast fluorescence imaging in vivo with conjugated polymer fluorophores in the second near-infrared window
journal, June 2014
- Hong, Guosong; Zou, Yingping; Antaris, Alexander L.
- Nature Communications, Vol. 5, Issue 1
Synovitis in Patients with Early Inflammatory Arthritis Monitored with Quantitative Analysis of Dynamic Contrast-enhanced Optical Imaging and MR Imaging
journal, January 2014
- Meier, Reinhard; Thuermel, Klaus; Noël, Peter B.
- Radiology, Vol. 270, Issue 1
Multifunctional in vivo vascular imaging using near-infrared II fluorescence
journal, November 2012
- Hong, Guosong; Lee, Jerry C.; Robinson, Joshua T.
- Nature Medicine, Vol. 18, Issue 12
Traumatic Brain Injury Imaging in the Second Near-Infrared Window with a Molecular Fluorophore
journal, June 2016
- Zhang, Xiao-Dong; Wang, Huasen; Antaris, Alexander L.
- Advanced Materials, Vol. 28, Issue 32
In Vivo Real-Time, Multicolor, Quantum Dot Lymphatic Imaging
journal, December 2009
- Kosaka, Nobuyuki.; Ogawa, Mikako; Sato, Noriko
- Journal of Investigative Dermatology, Vol. 129, Issue 12
Vessel architectural imaging identifies cancer patient responders to anti-angiogenic therapy
journal, August 2013
- Emblem, Kyrre E.; Mouridsen, Kim; Bjornerud, Atle
- Nature Medicine, Vol. 19, Issue 9
In vivo Imaging of Inflammation- and Tumor-Induced Lymph Node Lymphangiogenesis by Immuno-Positron Emission Tomography
journal, October 2010
- Mumprecht, V.; Honer, M.; Vigl, B.
- Cancer Research, Vol. 70, Issue 21
Increased Survival of Glioblastoma Patients Who Respond to Antiangiogenic Therapy with Elevated Blood Perfusion
journal, November 2011
- Sorensen, A. G.; Emblem, K. E.; Polaskova, P.
- Cancer Research, Vol. 72, Issue 2
Spatiotemporal analysis for indocyanine green-aided imaging of rheumatoid arthritis in hand joints
journal, September 2013
- Mohajerani, Pouyan; Meier, Reinhard; Noël, Peter B.
- Journal of Biomedical Optics, Vol. 18, Issue 9
Biodistribution, pharmacokinetics and toxicology of Ag2S near-infrared quantum dots in mice
journal, May 2013
- Zhang, Yan; Zhang, Yejun; Hong, Guosong
- Biomaterials, Vol. 34, Issue 14
Lymphatic imaging in humans with near-infrared fluorescence
journal, February 2009
- Rasmussen, John C.; Tan, I-Chih; Marshall, Milton V.
- Current Opinion in Biotechnology, Vol. 20, Issue 1
Vascular Endothelial Cell Growth Factor Receptor 3–Mediated Activation of Lymphatic Endothelium Is Crucial for Tumor Cell Entry and Spread via Lymphatic Vessels
journal, June 2005
- He, Yulong; Rajantie, Iiro; Pajusola, Katri
- Cancer Research, Vol. 65, Issue 11
Suppression of Tumor Invasion and Metastasis by Concurrent Inhibition of c-Met and VEGF Signaling in Pancreatic Neuroendocrine Tumors
journal, February 2012
- Sennino, Barbara; Ishiguro-Oonuma, Toshina; Wei, Ying
- Cancer Discovery, Vol. 2, Issue 3
Mechanisms underlying FeCl3-induced arterial thrombosis: Characterization of the FeCl3-induced thrombosis model
journal, April 2011
- Eckly, A.; Hechler, B.; Freund, M.
- Journal of Thrombosis and Haemostasis, Vol. 9, Issue 4
Technical Details of Intraoperative Lymphatic Mapping for Early Stage Melanoma
journal, April 1992
- Morton, Donald L.
- Archives of Surgery, Vol. 127, Issue 4
Magnetic Resonance Images Lipid, Fibrous, Calcified, Hemorrhagic, and Thrombotic Components of Human Atherosclerosis In Vivo
journal, September 1996
- Toussaint, Jean-Franc¸ois; LaMuraglia, Glenn M.; Southern, James F.
- Circulation, Vol. 94, Issue 5
Tumor-Targeted Multimodal Optical Imaging with Versatile Cadmium-Free Quantum Dots
journal, December 2015
- Liu, Xiangyou; Braun, Gary B.; Zhong, Haizheng
- Advanced Functional Materials, Vol. 26, Issue 2
Correlation Between Abdominal Perforator Vessels Identified With Preoperative CT Angiography and Intraoperative Fluorescent Angiography in the Microsurgical Breast Reconstruction Patient
journal, January 2014
- Pestana, Ivo A.; Zenn, Michael R.
- Annals of Plastic Surgery, Vol. 72
Targeted imaging of urothelium carcinoma in human bladders by an ICG pHLIP peptide ex vivo
journal, September 2016
- Golijanin, Jovana; Amin, Ali; Moshnikova, Anna
- Proceedings of the National Academy of Sciences, Vol. 113, Issue 42
In vivo real-time visualization of mesenchymal stem cells tropism for cutaneous regeneration using NIR-II fluorescence imaging
journal, June 2015
- Chen, Guangcun; Tian, Fei; Li, Chunyan
- Biomaterials, Vol. 53
In Vivo Fluorescence Imaging with Ag 2 S Quantum Dots in the Second Near-Infrared Region
journal, September 2012
- Hong, Guosong; Robinson, Joshua T.; Zhang, Yejun
- Angewandte Chemie, Vol. 124, Issue 39
Strained Cyclooctyne as a Molecular Platform for Construction of Multimodal Imaging Probes
journal, March 2015
- Sun, Yao; Ma, Xiaowei; Cheng, Kai
- Angewandte Chemie International Edition, Vol. 54, Issue 20
A small-molecule dye for NIR-II imaging
journal, November 2015
- Antaris, Alexander L.; Chen, Hao; Cheng, Kai
- Nature Materials, Vol. 15, Issue 2
Novel benzo-bis(1,2,5-thiadiazole) fluorophores for in vivo NIR-II imaging of cancer
journal, January 2016
- Sun, Yao; Qu, Chunrong; Chen, Hao
- Chemical Science, Vol. 7, Issue 9
Breast Cancer: Assessing Response to Neoadjuvant Chemotherapy by Using US-guided Near-Infrared Tomography
journal, February 2013
- Zhu, Quing; DeFusco, Patricia A.; Ricci, Andrew
- Radiology, Vol. 266, Issue 2
Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping
journal, December 2003
- Kim, Sungjee; Lim, Yong Taik; Soltesz, Edward G.
- Nature Biotechnology, Vol. 22, Issue 1
Fluorescence Imaging In Vivo at Wavelengths beyond 1500 nm
journal, October 2015
- Diao, Shuo; Blackburn, Jeffrey L.; Hong, Guosong
- Angewandte Chemie, Vol. 127, Issue 49
Tumor-derived hydrogen sulfide, produced by cystathionine- -synthase, stimulates bioenergetics, cell proliferation, and angiogenesis in colon cancer
journal, July 2013
- Szabo, C.; Coletta, C.; Chao, C.
- Proceedings of the National Academy of Sciences, Vol. 110, Issue 30
Liposomal drug delivery systems: From concept to clinical applications
journal, January 2013
- Allen, Theresa M.; Cullis, Pieter R.
- Advanced Drug Delivery Reviews, Vol. 65, Issue 1
Tumor Molecular Imaging with Nanoparticles
journal, March 2016
- Cheng, Zhen; Yan, Xuefeng; Sun, Xilin
- Engineering, Vol. 2, Issue 1
Fluorescence efficiency of four infrared polymethine dyes
journal, May 2003
- Casalboni, M.; De Matteis, F.; Prosposito, P.
- Chemical Physics Letters, Vol. 373, Issue 3-4
Facile Synthesis of Highly Photoluminescent Ag 2 Se Quantum Dots as a New Fluorescent Probe in the Second Near-Infrared Window for in Vivo Imaging
journal, June 2013
- Dong, Bohua; Li, Chunyan; Chen, Guangcun
- Chemistry of Materials, Vol. 25, Issue 12
Fluorescent imaging of cancerous tissues for targeted surgery
journal, September 2014
- Bu, Lihong; Shen, Baozhong; Cheng, Zhen
- Advanced Drug Delivery Reviews, Vol. 76
Preoperative Detection and Intraoperative Visualization of Brain Tumors for More Precise Surgery: A New Dual-Modality MRI and NIR Nanoprobe
journal, June 2015
- Li, Chunyan; Cao, Limin; Zhang, Yejun
- Small, Vol. 11, Issue 35
Carotid artery wall thickness: comparison between sonography and multi-detector row CT angiography
journal, September 2009
- Saba, Luca; Sanfilippo, Roberto; Montisci, Roberto
- Neuroradiology, Vol. 52, Issue 2
Strained Cyclooctyne as a Molecular Platform for Construction of Multimodal Imaging Probes
journal, March 2015
- Sun, Yao; Ma, Xiaowei; Cheng, Kai
- Angewandte Chemie, Vol. 127, Issue 20
Fluorescence Imaging In Vivo at Wavelengths beyond 1500 nm
journal, October 2015
- Diao, Shuo; Blackburn, Jeffrey L.; Hong, Guosong
- Angewandte Chemie International Edition, Vol. 54, Issue 49
Works referencing / citing this record:
Molecular Fluorescence and Photoacoustic Imaging in the Second Near-Infrared Optical Window Using Organic Contrast Agents
journal, March 2018
- Jiang, Yuyan; Pu, Kanyi
- Advanced Biosystems, Vol. 2, Issue 5
Conjugated Polymer Nanoparticles for Imaging, Cell Activity Regulation, and Therapy
journal, November 2018
- Wang, Yunxia; Feng, Liheng; Wang, Shu
- Advanced Functional Materials, Vol. 29, Issue 5
All‐in‐One Phototheranostics: Single Laser Triggers NIR‐II Fluorescence/Photoacoustic Imaging Guided Photothermal/Photodynamic/Chemo Combination Therapy
journal, April 2019
- Wang, Qi; Dai, Yeneng; Xu, Jingzeng
- Advanced Functional Materials, Vol. 29, Issue 31
Monitoring the Real‐Time Circulatory System‐Related Physiological and Pathological Processes In Vivo Using a Multifunctional NIR‐II Probe
journal, November 2019
- Li, Daifeng; Qu, Chunrong; Liu, Qiang
- Advanced Functional Materials, Vol. 30, Issue 6
Near-Infrared II Dye-Protein Complex for Biomedical Imaging and Imaging-Guided Photothermal Therapy
journal, July 2018
- Zeng, Xiaodong; Xiao, Yuling; Lin, Jiacheng
- Advanced Healthcare Materials, Vol. 7, Issue 18
Beyond 1000 nm Emission Wavelength: Recent Advances in Organic and Inorganic Emitters for Deep‐Tissue Molecular Imaging
journal, April 2019
- Ding, Feng; Fan, Yong; Sun, Yao
- Advanced Healthcare Materials, Vol. 8, Issue 14
Dual-Peak Absorbing Semiconducting Copolymer Nanoparticles for First and Second Near-Infrared Window Photothermal Therapy: A Comparative Study
journal, February 2018
- Jiang, Yuyan; Li, Jingchao; Zhen, Xu
- Advanced Materials, Vol. 30, Issue 14
Improved Stable Indocyanine Green (ICG)-Mediated Cancer Optotheranostics with Naturalized Hepatitis B Core Particles
journal, May 2018
- Shan, Wenjun; Chen, Ronghe; Zhang, Qiang
- Advanced Materials, Vol. 30, Issue 28
Organic Semiconducting Agents for Deep-Tissue Molecular Imaging: Second Near-Infrared Fluorescence, Self-Luminescence, and Photoacoustics
journal, July 2018
- Miao, Qingqing; Pu, Kanyi
- Advanced Materials, Vol. 30, Issue 49
Repurposing Cyanine NIR-I Dyes Accelerates Clinical Translation of Near-Infrared-II (NIR-II) Bioimaging
journal, July 2018
- Zhu, Shoujun; Hu, Zhubin; Tian, Rui
- Advanced Materials, Vol. 30, Issue 34
Near‐Infrared‐II Molecular Dyes for Cancer Imaging and Surgery
journal, April 2019
- Zhu, Shoujun; Tian, Rui; Antaris, Alexander L.
- Advanced Materials
Advanced Nanotechnology Leading the Way to Multimodal Imaging‐Guided Precision Surgical Therapy
journal, September 2019
- Wang, Cong; Fan, Wenpei; Zhang, Zijian
- Advanced Materials, Vol. 31, Issue 49
Enhancing Photoacoustic Intensity of Upconversion Nanoparticles by Photoswitchable Azobenzene‐Containing Polymers for Dual NIR‐II and Photoacoustic Imaging In Vivo
journal, April 2019
- He, Shuqing; Song, Jun; Liu, Jianfeng
- Advanced Optical Materials, Vol. 7, Issue 12
An IR820 Dye–Protein Complex for Second Near‐Infrared Window and Photoacoustic Imaging
journal, December 2019
- Du, Bulin; Qu, Chunrong; Qian, Kun
- Advanced Optical Materials, Vol. 8, Issue 4
Recent Advance in Near‐Infrared (NIR) Imaging Probes for Cancer Theranostics
journal, August 2018
- Liu, Yuxin; Jia, Qi; Zhou, Jing
- ADVANCED THERAPEUTICS, Vol. 1, Issue 8
Advanced NIR‐II Fluorescence Imaging Technology for In Vivo Precision Tumor Theranostics
journal, May 2019
- Li, Chunyan; Wang, Qiangbin
- Advanced Therapeutics, Vol. 2, Issue 9
Aggregation‐Induced Absorption Enhancement for Deep Near‐Infrared II Photoacoustic Imaging of Brain Gliomas In Vivo
journal, January 2019
- Liu, Yajing; Liu, Huanhuan; Yan, Huixiang
- Advanced Science, Vol. 6, Issue 8
Excretable Lanthanide Nanoparticle for Biomedical Imaging and Surgical Navigation in the Second Near‐Infrared Window
journal, September 2019
- Li, Daifeng; He, Shuqing; Wu, Yifan
- Advanced Science, Vol. 6, Issue 23
Fluorometric Imaging for Early Diagnosis and Prognosis of Rheumatoid Arthritis
journal, December 2019
- Lee, Jeong Heon; Jung, Sang Youn; Park, G. Kate
- Advanced Science, Vol. 7, Issue 1
Imaging of Colorectal Cancers Using Activatable Nanoprobes with Second Near-Infrared Window Emission
journal, February 2018
- Xu, Ge; Yan, Qinglong; Lv, Xiaoguang
- Angewandte Chemie International Edition, Vol. 57, Issue 14
Recent Progress in Fluorescence Imaging of the Near‐Infrared II Window
journal, November 2018
- Miao, Yawei; Gu, Chuantao; Zhu, Yaowei
- ChemBioChem, Vol. 19, Issue 24
Synthesis of Highly Fluorescent Yellow-Green N-Doped Carbon Nanorings for pH Variation Detection and Bioimaging
journal, August 2018
- Xu, Quan; Su, Rigu; Zhong, Jian
- Particle & Particle Systems Characterization, Vol. 35, Issue 10
Hierarchically Nanostructured Hybrid Platform for Tumor Delineation and Image‐Guided Surgery via NIR‐II Fluorescence and PET Bimodal Imaging
journal, September 2019
- Zhang, Qing; Zhou, Huijun; Chen, Hao
- Small, Vol. 15, Issue 45
Novel dual-function near-infrared II fluorescence and PET probe for tumor delineation and image-guided surgery
journal, January 2018
- Sun, Yao; Zeng, Xiaodong; Xiao, Yuling
- Chemical Science, Vol. 9, Issue 8
Tailoring the morphology of AIEgen fluorescent nanoparticles for optimal cellular uptake and imaging efficacy
journal, January 2018
- Zhang, Jianxu; Xu, Bin; Tian, Wenjing
- Chemical Science, Vol. 9, Issue 9
NIR-I-to-NIR-II fluorescent nanomaterials for biomedical imaging and cancer therapy
journal, January 2018
- Zhao, Jingya; Zhong, Dian; Zhou, Shaobing
- Journal of Materials Chemistry B, Vol. 6, Issue 3
A NIR-II fluorescent probe for articular cartilage degeneration imaging and osteoarthritis detection
journal, January 2019
- Yi, Wanrong; Zhou, Hui; Li, Anguo
- Biomaterials Science, Vol. 7, Issue 3
Development of organic semiconducting materials for deep-tissue optical imaging, phototherapy and photoactivation
journal, January 2019
- Li, Jingchao; Pu, Kanyi
- Chemical Society Reviews, Vol. 48, Issue 1
Crucial breakthrough of second near-infrared biological window fluorophores: design and synthesis toward multimodal imaging and theranostics
journal, January 2018
- He, Shuqing; Song, Jun; Qu, Junle
- Chemical Society Reviews, Vol. 47, Issue 12
A highly water-soluble triblock conjugated polymer for in vivo NIR-II imaging and photothermal therapy of cancer
journal, January 2018
- Lu, Xiaomei; Yuan, Pengcheng; Zhang, Wansu
- Polymer Chemistry, Vol. 9, Issue 22
Diketopyrrolopyrrole-based semiconducting polymer nanoparticles for in vivo second near-infrared window imaging and image-guided tumor surgery
journal, January 2018
- Shou, Kangquan; Tang, Yufu; Chen, Hao
- Chemical Science, Vol. 9, Issue 12
Recent advances in near-infrared II fluorophores for multifunctional biomedical imaging
journal, January 2018
- Ding, Feng; Zhan, Yibei; Lu, Xiaoju
- Chemical Science, Vol. 9, Issue 19
Novel near-infrared II aggregation-induced emission dots for in vivo bioimaging
journal, January 2019
- Lin, Jiacheng; Zeng, Xiaodong; Xiao, Yuling
- Chemical Science, Vol. 10, Issue 4
Single nanoparticles as versatile phototheranostics for tri-modal imaging-guided photothermal therapy
journal, January 2019
- Lu, Xiaomei; Chen, Jiaqi; Li, Jie
- Biomaterials Science, Vol. 7, Issue 9
Tuning the near infrared II emitting wavelength of small molecule dyes by single atom alteration
journal, January 2020
- Qian, Kun; Qu, Chunrong; Ma, Xiangyu
- Chemical Communications, Vol. 56, Issue 4
Rational design of a multifunctional molecular dye for dual-modal NIR-II/photoacoustic imaging and photothermal therapy
journal, January 2019
- Zhang, Ruiping; Xu, Yuling; Zhang, Yi
- Chemical Science, Vol. 10, Issue 36
Critical Review—Recent Progress in NIR Fluorophores Emitting over 1000 nm for Bioimaging
journal, January 2019
- Jin, Takashi
- ECS Journal of Solid State Science and Technology, Vol. 8, Issue 1