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Title: Multifunctional Biomedical Imaging in Physiological and Pathological Conditions Using a NIR-II Probe

Abstract

Contrasted with imaging in the visible (400–650 nm) and near-infrared window I (NIR-I, 650–900 nm) regions, imaging in near-infrared window II (NIR-II, 1000–1700 nm) is a highly promising in vivo imaging modality with improved resolution and deeper tissue penetration. Here, a small molecule NIR-II dye,5,5'-(1H,5H-benzo[1,2-c:4,5-c'] bis[1,2,5]thiadiazole)-4,8-diyl)bis(N,N-bis(4-(3-((tert-butyldimethylsilyl)oxy)propyl)phenyl) thiophen-2-amine), is successfully encapsulated into phospholipid vesicles to prepare a probe CQS1000. The novel NIR-II probe is studied for in vivo multifunctional biological imaging. The results of this study indicate that the NIR-II vesicle CQS1000 can noninvasively and dynamically visualize and monitor many physiological and pathological conditions of circulatory systems, including lymphatic drainage and routing, angiogenesis of tumor, and vascular deformity such as arterial thrombus formation and ischemia with high spatial and temporal resolution. More importantly, by virtue of the favorable half-life of blood circulation of CQS1000, NIR-II imaging is capable of aiding precise resection of tumor such as osteosarcoma and accelerating the process of lymph node dissection to complete sentinel lymph node biopsy for better decision making during the tumor surgery. Overall, CQS1000 is a highly promising NIR-II probe for multifunctional biomedical imaging in physiological and pathological conditions, surpassing traditional NIR-I imaging modality and pathologic assessments for clinical diagnosis and treatment.

Authors:
 [1];  [1];  [1];  [2];  [2];  [2];  [3];  [3];  [3];  [2]
  1. Wuhan Univ. (China); Stanford Univ., CA (United States)
  2. Stanford Univ., CA (United States)
  3. Wuhan Univ. (China)
Publication Date:
Research Org.:
Stanford Univ., CA (United States)
Sponsoring Org.:
USDOE Office of Science (SC)
OSTI Identifier:
1533019
Alternate Identifier(s):
OSTI ID: 1400851
Grant/Contract Number:  
SC0008397
Resource Type:
Journal Article: Accepted Manuscript
Journal Name:
Advanced Functional Materials
Additional Journal Information:
Journal Volume: 27; Journal Issue: 23; Journal ID: ISSN 1616-301X
Publisher:
Wiley
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE; chemistry; science & technology; materials science; physics; fluorescence imaging; lymphatic system; NIR‐II probes; sentinel lymph nodes; tumors; vascular system

Citation Formats

Shou, Kangquan, Qu, Chunrong, Sun, Yao, Chen, Hao, Chen, Si, Zhang, Lei, Xu, Haibo, Hong, Xuechuan, Yu, Aixi, and Cheng, Zhen. Multifunctional Biomedical Imaging in Physiological and Pathological Conditions Using a NIR-II Probe. United States: N. p., 2017. Web. doi:10.1002/adfm.201700995.
Shou, Kangquan, Qu, Chunrong, Sun, Yao, Chen, Hao, Chen, Si, Zhang, Lei, Xu, Haibo, Hong, Xuechuan, Yu, Aixi, & Cheng, Zhen. Multifunctional Biomedical Imaging in Physiological and Pathological Conditions Using a NIR-II Probe. United States. https://doi.org/10.1002/adfm.201700995
Shou, Kangquan, Qu, Chunrong, Sun, Yao, Chen, Hao, Chen, Si, Zhang, Lei, Xu, Haibo, Hong, Xuechuan, Yu, Aixi, and Cheng, Zhen. Mon . "Multifunctional Biomedical Imaging in Physiological and Pathological Conditions Using a NIR-II Probe". United States. https://doi.org/10.1002/adfm.201700995. https://www.osti.gov/servlets/purl/1533019.
@article{osti_1533019,
title = {Multifunctional Biomedical Imaging in Physiological and Pathological Conditions Using a NIR-II Probe},
author = {Shou, Kangquan and Qu, Chunrong and Sun, Yao and Chen, Hao and Chen, Si and Zhang, Lei and Xu, Haibo and Hong, Xuechuan and Yu, Aixi and Cheng, Zhen},
abstractNote = {Contrasted with imaging in the visible (400–650 nm) and near-infrared window I (NIR-I, 650–900 nm) regions, imaging in near-infrared window II (NIR-II, 1000–1700 nm) is a highly promising in vivo imaging modality with improved resolution and deeper tissue penetration. Here, a small molecule NIR-II dye,5,5'-(1H,5H-benzo[1,2-c:4,5-c'] bis[1,2,5]thiadiazole)-4,8-diyl)bis(N,N-bis(4-(3-((tert-butyldimethylsilyl)oxy)propyl)phenyl) thiophen-2-amine), is successfully encapsulated into phospholipid vesicles to prepare a probe CQS1000. The novel NIR-II probe is studied for in vivo multifunctional biological imaging. The results of this study indicate that the NIR-II vesicle CQS1000 can noninvasively and dynamically visualize and monitor many physiological and pathological conditions of circulatory systems, including lymphatic drainage and routing, angiogenesis of tumor, and vascular deformity such as arterial thrombus formation and ischemia with high spatial and temporal resolution. More importantly, by virtue of the favorable half-life of blood circulation of CQS1000, NIR-II imaging is capable of aiding precise resection of tumor such as osteosarcoma and accelerating the process of lymph node dissection to complete sentinel lymph node biopsy for better decision making during the tumor surgery. Overall, CQS1000 is a highly promising NIR-II probe for multifunctional biomedical imaging in physiological and pathological conditions, surpassing traditional NIR-I imaging modality and pathologic assessments for clinical diagnosis and treatment.},
doi = {10.1002/adfm.201700995},
url = {https://www.osti.gov/biblio/1533019}, journal = {Advanced Functional Materials},
issn = {1616-301X},
number = 23,
volume = 27,
place = {United States},
year = {2017},
month = {4}
}

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