Intracellular Dynamics of Superparamagnetic Iron Oxide Nanoparticles for Magnetic Partical Imaging
Abstract
Superparamagnetic iron oxide nanoparticles (SPIONs) are a foundational platform for a variety of biomedical applications. Of particular interest is Magnetic Particle Imaging (MPI), which is a growing area of research and development due to its advantages including high resolution and sensitivity with positive contrast. There has been signicant work in the area of in vivo optimization of SPIONs for MPI as well as their biodistribution in and clearance from the body. However, little is known about the dynamics of SPIONs following cellular internalization which may limit their usefulness in a variety of potential imaging and treatment applications. This work shows a clear 20% decrease in magnetic performance of SPIONs, as observed by Magnetic Particle Spectroscopy (MPS), after internalization and systematic consideration of applicable factors that aect SPION signal generation, including microstructure, environment, and interparticle interactions. There is no observed change to SPION microstructure after internalization, and the surrounding environment plays little to no role in magnetic response for the SPIONs studied here. Interparticle interactions described by dipole-dipole coupling of SPIONs held close to one another after internalization are shown to be the dominant cause of decreased magnetic performance in cells. These conclusions were drawn from transmission electron microscopy (TEM) imagemore »
- Authors:
-
- UNIVERSITY OF WASHINGTON
- University of Washington
- BATTELLE (PACIFIC NW LAB)
- Publication Date:
- Research Org.:
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1530859
- Report Number(s):
- PNNL-SA-141236
- DOE Contract Number:
- AC05-76RL01830
- Resource Type:
- Journal Article
- Journal Name:
- Nanoscale
- Additional Journal Information:
- Journal Volume: 11; Journal Issue: 16
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Teeman, Eric M., Shasha, Carolyn, Evans, James E., and Krishan, Kannan. Intracellular Dynamics of Superparamagnetic Iron Oxide Nanoparticles for Magnetic Partical Imaging. United States: N. p., 2019.
Web. doi:10.1039/c9nr01395d.
Teeman, Eric M., Shasha, Carolyn, Evans, James E., & Krishan, Kannan. Intracellular Dynamics of Superparamagnetic Iron Oxide Nanoparticles for Magnetic Partical Imaging. United States. https://doi.org/10.1039/c9nr01395d
Teeman, Eric M., Shasha, Carolyn, Evans, James E., and Krishan, Kannan. 2019.
"Intracellular Dynamics of Superparamagnetic Iron Oxide Nanoparticles for Magnetic Partical Imaging". United States. https://doi.org/10.1039/c9nr01395d.
@article{osti_1530859,
title = {Intracellular Dynamics of Superparamagnetic Iron Oxide Nanoparticles for Magnetic Partical Imaging},
author = {Teeman, Eric M. and Shasha, Carolyn and Evans, James E. and Krishan, Kannan},
abstractNote = {Superparamagnetic iron oxide nanoparticles (SPIONs) are a foundational platform for a variety of biomedical applications. Of particular interest is Magnetic Particle Imaging (MPI), which is a growing area of research and development due to its advantages including high resolution and sensitivity with positive contrast. There has been signicant work in the area of in vivo optimization of SPIONs for MPI as well as their biodistribution in and clearance from the body. However, little is known about the dynamics of SPIONs following cellular internalization which may limit their usefulness in a variety of potential imaging and treatment applications. This work shows a clear 20% decrease in magnetic performance of SPIONs, as observed by Magnetic Particle Spectroscopy (MPS), after internalization and systematic consideration of applicable factors that aect SPION signal generation, including microstructure, environment, and interparticle interactions. There is no observed change to SPION microstructure after internalization, and the surrounding environment plays little to no role in magnetic response for the SPIONs studied here. Interparticle interactions described by dipole-dipole coupling of SPIONs held close to one another after internalization are shown to be the dominant cause of decreased magnetic performance in cells. These conclusions were drawn from transmission electron microscopy (TEM) image analysis at relevant length scales, experimentally prepared and characterized SPIONs in varied environmental conditions, and theoretical modeling with Monte Carlo simulations.},
doi = {10.1039/c9nr01395d},
url = {https://www.osti.gov/biblio/1530859},
journal = {Nanoscale},
number = 16,
volume = 11,
place = {United States},
year = {Sun Apr 28 00:00:00 EDT 2019},
month = {Sun Apr 28 00:00:00 EDT 2019}
}
Works referenced in this record:
Molecular imaging in living subjects: seeing fundamental biological processes in a new light
journal, March 2003
- Massoud, T. F.
- Genes & Development, Vol. 17, Issue 5
Cancer nanotechnology: opportunities and challenges
journal, March 2005
- Ferrari, Mauro
- Nature Reviews Cancer, Vol. 5, Issue 3, p. 161-171
Stem Cell Imaging: From Bench to Bedside
journal, April 2014
- Nguyen, Patricia K.; Riegler, Johannes; Wu, Joseph C.
- Cell Stem Cell, Vol. 14, Issue 4
Tomographic imaging using the nonlinear response of magnetic particles
journal, June 2005
- Gleich, Bernhard; Weizenecker, Jürgen
- Nature, Vol. 435, Issue 7046
Magnetic Particle Imaging for Real-Time Perfusion Imaging in Acute Stroke
journal, October 2017
- Ludewig, Peter; Gdaniec, Nadine; Sedlacik, Jan
- ACS Nano, Vol. 11, Issue 10
Magnetic Particle Imaging: A Novel in Vivo Imaging Platform for Cancer Detection
journal, February 2017
- Yu, Elaine Y.; Bishop, Mindy; Zheng, Bo
- Nano Letters, Vol. 17, Issue 3
Magnetic Particle Imaging tracks the long-term fate of in vivo neural cell implants with high image contrast
journal, September 2015
- Zheng, Bo; Vazin, Tandis; Goodwill, Patrick W.
- Scientific Reports, Vol. 5, Issue 1
Magnetic Particle Imaging for Highly Sensitive, Quantitative, and Safe in Vivo Gut Bleed Detection in a Murine Model
journal, October 2016
- Yu, Elaine Y.; Chandrasekharan, Prashant; Berzon, Ran
- ACS Nano, Vol. 11, Issue 12
Three-dimensional real-time in vivo magnetic particle imaging
journal, February 2009
- Weizenecker, J.; Gleich, B.; Rahmer, J.
- Physics in Medicine and Biology, Vol. 54, Issue 5
X-Space MPI: Magnetic Nanoparticles for Safe Medical Imaging
journal, March 2012
- Goodwill, Patrick William; Saritas, Emine Ulku; Croft, Laura Rose
- Advanced Materials, Vol. 24, Issue 28
Evaluation of PEG-coated iron oxide nanoparticles as blood pool tracers for preclinical magnetic particle imaging
journal, January 2017
- Khandhar, A. P.; Keselman, P.; Kemp, S. J.
- Nanoscale, Vol. 9, Issue 3
Mixed Brownian alignment and Néel rotations in superparamagnetic iron oxide nanoparticle suspensions driven by an ac field
journal, September 2015
- Shah, Saqlain A.; Reeves, Daniel B.; Ferguson, R. Matthew
- Physical Review B, Vol. 92, Issue 9
Towards Picogram Detection of Superparamagnetic Iron-Oxide Particles Using a Gradiometric Receive Coil
journal, July 2017
- Graeser, Matthias; Knopp, Tobias; Szwargulski, Patryk
- Scientific Reports, Vol. 7, Issue 1
Magnetic particle imaging: kinetics of the intravascular signal in vivo
journal, September 2014
- Haegele, Julian; Lüdtke-Buzug, Kerstin; Schaecke, Catharina
- International Journal of Nanomedicine
Magnetic Particle Imaging With Tailored Iron Oxide Nanoparticle Tracers
journal, May 2015
- Ferguson, R. Matthew; Khandhar, Amit P.; Kemp, Scott J.
- IEEE Transactions on Medical Imaging, Vol. 34, Issue 5
In vivo delivery, pharmacokinetics, biodistribution and toxicity of iron oxide nanoparticles
journal, January 2015
- Arami, Hamed; Khandhar, Amit; Liggitt, Denny
- Chemical Society Reviews, Vol. 44, Issue 23
Monodisperse magnetite nanoparticles with nearly ideal saturation magnetization
journal, January 2016
- Kemp, Scott J.; Ferguson, R. Matthew; Khandhar, Amit P.
- RSC Advances, Vol. 6, Issue 81
Understanding and controlling the interaction of nanomaterials with proteins in a physiological environment
journal, January 2012
- Walkey, Carl D.; Chan, Warren C. W.
- Chem. Soc. Rev., Vol. 41, Issue 7
Parameters influencing the stealthiness of colloidal drug delivery systems
journal, August 2006
- Vonarbourg, Arnaud; Passirani, Catherine; Saulnier, Patrick
- Biomaterials, Vol. 27, Issue 24
Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts
journal, September 2008
- Lundqvist, M.; Stigler, J.; Elia, G.
- Proceedings of the National Academy of Sciences, Vol. 105, Issue 38
Impact of serum proteins on MRI contrast agents: cellular binding and T 2 relaxation
journal, January 2014
- Hill, Alexandra; Payne, Christine K.
- RSC Adv., Vol. 4, Issue 60
Intermolecular forces in biology
journal, May 2001
- Leckband, Deborah; Israelachvili, Jacob
- Quarterly Reviews of Biophysics, Vol. 34, Issue 2
The EPR effect for macromolecular drug delivery to solid tumors: Improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo
journal, January 2013
- Maeda, Hiroshi; Nakamura, Hideaki; Fang, Jun
- Advanced Drug Delivery Reviews, Vol. 65, Issue 1
From The Cover: Mechanics of receptor-mediated endocytosis
journal, June 2005
- Gao, H.; Shi, W.; Freund, L. B.
- Proceedings of the National Academy of Sciences, Vol. 102, Issue 27
Endocytosis at the nanoscale
journal, January 2012
- Canton, Irene; Battaglia, Giuseppe
- Chemical Society Reviews, Vol. 41, Issue 7
Pathways and mechanisms of endocytic recycling
journal, September 2009
- Grant, Barth D.; Donaldson, Julie G.
- Nature Reviews Molecular Cell Biology, Vol. 10, Issue 9
Unambiguous observation of shape effects on cellular fate of nanoparticles
journal, March 2014
- Chu, Zhiqin; Zhang, Silu; Zhang, Bokai
- Scientific Reports, Vol. 4, Issue 1
Endocytosis of nanomedicines
journal, August 2010
- Sahay, Gaurav; Alakhova, Daria Y.; Kabanov, Alexander V.
- Journal of Controlled Release, Vol. 145, Issue 3
Ultra-large-scale syntheses of monodisperse nanocrystals
journal, November 2004
- Park, Jongnam; An, Kwangjin; Hwang, Yosun
- Nature Materials, Vol. 3, Issue 12
Hydrophobic Nanocrystals Coated with an Amphiphilic Polymer Shell: A General Route to Water Soluble Nanocrystals
journal, April 2004
- Pellegrino, Teresa; Manna, Liberato; Kudera, Stefan
- Nano Letters, Vol. 4, Issue 4, p. 703-707
Aqueous dispersion of monodisperse magnetic iron oxide nanocrystals through phase transfer
journal, August 2006
- Yu, William W.; Chang, Emmanuel; Sayes, Christie M.
- Nanotechnology, Vol. 17, Issue 17
Tracer design for magnetic particle imaging (invited)
journal, April 2012
- Ferguson, R. Matthew; Khandhar, Amit P.; Krishnan, Kannan M.
- Journal of Applied Physics, Vol. 111, Issue 7
Harmonic Simulation Study of Simultaneous Nanoparticle Size and Viscosity Differentiation
journal, January 2017
- Shasha, Carolyn; Teeman, Eric; Krishnan, Kannan M.
- IEEE Magnetics Letters, Vol. 8
Lysosomal Acidification Mechanisms
journal, March 2012
- Mindell, Joseph A.
- Annual Review of Physiology, Vol. 74, Issue 1
Long term in vivo biotransformation of iron oxide nanoparticles
journal, June 2011
- Levy, Michael; Luciani, Nathalie; Alloyeau, Damien
- Biomaterials, Vol. 32, Issue 16
How the size distribution of magnetic nanoparticles determines their magnetic particle imaging performance
journal, May 2011
- Eberbeck, D.; Wiekhorst, F.; Wagner, S.
- Applied Physics Letters, Vol. 98, Issue 18
Size-dependent ferrohydrodynamic relaxometry of magnetic particle imaging tracers in different environments: Optimized tracers for magnetic particle imaging
journal, June 2013
- Arami, Hamed; Ferguson, R. M.; Khandhar, Amit P.
- Medical Physics, Vol. 40, Issue 7
Intracellular performance of tailored nanoparticle tracers in magnetic particle imaging
journal, May 2014
- Arami, Hamed; Krishnan, Kannan M.
- Journal of Applied Physics, Vol. 115, Issue 17
Massive Intracellular Biodegradation of Iron Oxide Nanoparticles Evidenced Magnetically at Single-Endosome and Tissue Levels
journal, July 2016
- Mazuel, François; Espinosa, Ana; Luciani, Nathalie
- ACS Nano, Vol. 10, Issue 8
Biodegradation of Iron Oxide Nanocubes: High-Resolution In Situ Monitoring
journal, May 2013
- Lartigue, Lénaic; Alloyeau, Damien; Kolosnjaj-Tabi, Jelena
- ACS Nano, Vol. 7, Issue 5
Specific Gravity of Glycerol 1
journal, December 1928
- Bosart, L. W.; Snoddy, A. O.
- Industrial & Engineering Chemistry, Vol. 20, Issue 12
Formula for the Viscosity of a Glycerol−Water Mixture
journal, May 2008
- Cheng, Nian-Sheng
- Industrial & Engineering Chemistry Research, Vol. 47, Issue 9