Sequestration of carbon dioxide with hydrogen to useful products

Adams, Michael W. W.; Kelly, Robert M.; Hawkins, Aaron B.; Menon, Angeli Lal; Lipscomb, Gina Lynette Pries; Schut, Gerrit Jan

Title: Sequestration of carbon dioxide with hydrogen to useful products

Patent · Tue Mar 12 00:00:00 EDT 2019

OSTI ID:1525055

Adams, Michael W. W.; Kelly, Robert M.; Hawkins, Aaron B.; Menon, Angeli Lal; Lipscomb, Gina Lynette Pries; Schut, Gerrit Jan

Provided herein are genetically engineered microbes that include at least a portion of a carbon fixation pathway, and in one embodiment, use molecular hydrogen to drive carbon dioxide fixation. In one embodiment, the genetically engineered microbe is modified to convert acetyl CoA, molecular hydrogen, and carbon dioxide to 3-hydroxypropionate, 4-hydroxybutyrate, acetyl CoA, or the combination thereof at levels greater than a control microbe. Other products may also be produced. Also provided herein are cell free compositions that convert acetyl CoA, molecular hydrogen, and carbon dioxide to 3-hydroxypropionate, 4-hydroxybutyrate, acetyl CoA, or the combination thereof. Also provided herein are methods of using the genetically engineered microbes and the cell free compositions.

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Research Organization:: Univ. of Georgia, Athens, GA (United States); North Carolina State University, Raleigh, NC (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AR0000081

Assignee:: University of Georgia Research Foundation, Inc. (Athens, GA); North Carolina State University (Raleigh, NC)

Patent Number(s):: 10,227,617

Application Number:: 15/410,205

OSTI ID:: 1525055

Resource Relation:: Patent File Date: 2017-01-19

Country of Publication:: United States

Language:: English

References (23)

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