Terahertz hyperspectral imaging with dual chip-scale combs

Sterczewski, Lukasz A.; Westberg, Jonas; Yang, Yang; Burghoff, David; Reno, John; Hu, Qing; Wysocki, Gerard

doi:10.1364/OPTICA.6.000766

Title: Terahertz hyperspectral imaging with dual chip-scale combs

Journal Article · Fri May 31 00:00:00 EDT 2019 · Optica

DOI:https://doi.org/10.1364/OPTICA.6.000766· OSTI ID:1523699

;

; Yang, Yang;

; Reno, John; Hu, Qing;

Hyperspectral imaging is a spectroscopic imaging technique that allows for the creation of images with pixels containing information from multiple spectral bands. At terahertz wavelengths, it has emerged as a prominent tool for a number of applications, ranging from nonionizing cancer diagnosis and pharmaceutical characterization to nondestructive artifact testing. Contemporary terahertz imaging systems typically rely on nonlinear optical downconversion of a fiber-based near-infrared femtosecond laser, requiring complex optical systems. In this work, we show hyperspectral imaging with chip-scale frequency combs based on terahertz quantum cascade lasers. The dual combs are free-running and emit coherent terahertz radiation that covers a bandwidth of 220 GHz at 3.4 THz with ~10 μW per line. The combination of the fast acquisition rate of dual-comb spectroscopy with the monolithic design, scalability, and chip-scale size of the combs is highly appealing for future imaging applications in biomedicine and the pharmaceutical industry.

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Research Organization:: Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

Sponsoring Organization:: USDOE National Nuclear Security Administration (NNSA); USDOE Office of Science (SC), Basic Energy Sciences (BES). Scientific User Facilities Division; Defense Advanced Research Projects Agency (DARPA)

Grant/Contract Number:: NA-0003525; AC04-94AL85000; W31P4Q-16-1-0001

OSTI ID:: 1523699

Alternate ID(s):: OSTI ID: 1529134

Report Number(s):: SAND-2019-0534J

Journal Information:: Optica, Journal Name: Optica Vol. 6 Journal Issue: 6; ISSN 2334-2536

Publisher:: Optical Society of AmericaCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 50 works

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Mid-infrared multiheterodyne spectroscopy with phase-locked quantum cascade lasers Westberg, J.; Sterczewski, L. A.; Wysocki, G. Applied Physics Letters, Vol. 110, Issue 14 https://doi.org/10.1063/1.4979825	journal	April 2017
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Non-invasive investigation of art paintings by terahertz imaging Abraham, E.; Younus, A.; Delagnes, J. C. Applied Physics A, Vol. 100, Issue 3 https://doi.org/10.1007/s00339-010-5642-z	journal	March 2010
Terahertz imaging for non-destructive evaluation of mural paintings Jackson, J. B.; Mourou, M.; Whitaker, J. F. Optics Communications, Vol. 281, Issue 4 https://doi.org/10.1016/j.optcom.2007.10.049	journal	February 2008
Analysis of Coating Structures and Interfaces in Solid Oral Dosage Forms by Three Dimensional Terahertz Pulsed Imaging Zeitler, J. Axel; Shen, Yaochun; Baker, Colin Journal of Pharmaceutical Sciences, Vol. 96, Issue 2 https://doi.org/10.1002/jps.20789	journal	February 2007
Nondestructive Analysis of Tablet Coating Thicknesses Using Terahertz Pulsed Imaging Fitzgerald, Anthony J.; Cole, Bryan E.; Taday, Philip F. Journal of Pharmaceutical Sciences, Vol. 94, Issue 1 https://doi.org/10.1002/jps.20225	journal	January 2005
Dual-comb spectroscopy Coddington, Ian; Newbury, Nathan; Swann, William Optica, Vol. 3, Issue 4 https://doi.org/10.1364/OPTICA.3.000414	journal	January 2016
Dual comb operation of λ ∼ 8.2 μ m quantum cascade laser frequency comb with 1 W optical power Jouy, P.; Wolf, J. M.; Bidaux, Y. Applied Physics Letters, Vol. 111, Issue 14 https://doi.org/10.1063/1.4985102	journal	October 2017
Terahertz multiheterodyne spectroscopy using laser frequency combs Yang, Yang; Burghoff, David; Hayton, Darren J. Optica, Vol. 3, Issue 5 https://doi.org/10.1364/OPTICA.3.000499	journal	January 2016
Adaptive sampling dual terahertz comb spectroscopy using dual free-running femtosecond lasers Yasui, Takeshi; Ichikawa, Ryuji; Hsieh, Yi-Da Scientific Reports, Vol. 5, Issue 1 https://doi.org/10.1038/srep10786	journal	June 2015
Terahertz laser frequency combs Burghoff, David; Kao, Tsung-Yu; Han, Ningren Nature Photonics, Vol. 8, Issue 6 https://doi.org/10.1038/nphoton.2014.85	journal	May 2014
Quantum cascade lasers: 20 years of challenges Vitiello, Miriam Serena; Scalari, Giacomo; Williams, Benjamin Optics Express, Vol. 23, Issue 4 https://doi.org/10.1364/OE.23.005167	journal	January 2015
Lateral Heterogeneous Integration of Quantum Cascade Lasers Yang, Yang; Paulsen, Andrew; Burghoff, David ACS Photonics, Vol. 5, Issue 7 https://doi.org/10.1021/acsphotonics.8b00507	journal	December 2017

Cited By (29)

Nondestructive Analysis of Tablet Coating Thicknesses Using Terahertz Pulsed Imaging Fitzgerald, Anthony J.; Cole, Bryan E.; Taday, Philip F. Journal of Pharmaceutical Sciences, Vol. 94, Issue 1 https://doi.org/10.1002/jps.20225	journal	January 2005
Analysis of Coating Structures and Interfaces in Solid Oral Dosage Forms by Three Dimensional Terahertz Pulsed Imaging Zeitler, J. Axel; Shen, Yaochun; Baker, Colin Journal of Pharmaceutical Sciences, Vol. 96, Issue 2 https://doi.org/10.1002/jps.20789	journal	February 2007
Non-invasive investigation of art paintings by terahertz imaging Abraham, E.; Younus, A.; Delagnes, J. C. Applied Physics A, Vol. 100, Issue 3 https://doi.org/10.1007/s00339-010-5642-z	journal	March 2010
Optically pumped far infrared lasers Jacobsson, Stellan Infrared Physics, Vol. 29, Issue 5 https://doi.org/10.1016/0020-0891(89)90035-3	journal	July 1989
The HITRAN2016 molecular spectroscopic database Gordon, I. E.; Rothman, L. S.; Hill, C. Journal of Quantitative Spectroscopy and Radiative Transfer, Vol. 203 https://doi.org/10.1016/j.jqsrt.2017.06.038	journal	December 2017
Terahertz time-domain spectroscopy of l-histidine hydrochloride monohydrate Zong, Siqi; Ren, GuanHua; Li, Shaoping Journal of Molecular Structure, Vol. 1157 https://doi.org/10.1016/j.molstruc.2017.12.088	journal	April 2018
Terahertz imaging for non-destructive evaluation of mural paintings Jackson, J. B.; Mourou, M.; Whitaker, J. F. Optics Communications, Vol. 281, Issue 4 https://doi.org/10.1016/j.optcom.2007.10.049	journal	February 2008
Temperature dependent terahertz pulsed spectroscopy of carbamazepine Zeitler, J. Axel; Newnham, David A.; Taday, Philip F. Thermochimica Acta, Vol. 436, Issue 1-2 https://doi.org/10.1016/j.tca.2005.07.006	journal	October 2005
Single-Shot Sub-microsecond Mid-infrared Spectroscopy on Protein Reactions with Quantum Cascade Laser Frequency Combs Klocke, Jessica L.; Mangold, Markus; Allmendinger, Pitt Analytical Chemistry, Vol. 90, Issue 17 https://doi.org/10.1021/acs.analchem.8b02531	journal	August 2018
Lateral Heterogeneous Integration of Quantum Cascade Lasers Yang, Yang; Paulsen, Andrew; Burghoff, David ACS Photonics, Vol. 5, Issue 7 https://doi.org/10.1021/acsphotonics.8b00507	journal	December 2017
Mid-infrared frequency comb based on a quantum cascade laser Hugi, Andreas; Villares, Gustavo; Blaser, Stéphane Nature, Vol. 492, Issue 7428 https://doi.org/10.1038/nature11620	journal	December 2012
Dual-comb spectroscopy based on quantum-cascade-laser frequency combs Villares, Gustavo; Hugi, Andreas; Blaser, Stéphane Nature Communications, Vol. 5, Issue 1 https://doi.org/10.1038/ncomms6192	journal	October 2014
Terahertz quantum-cascade lasers Williams, Benjamin S. Nature Photonics, Vol. 1, Issue 9 https://doi.org/10.1038/nphoton.2007.166	journal	September 2007
Cutting-edge terahertz technology Tonouchi, Masayoshi Nature Photonics, Vol. 1, Issue 2 https://doi.org/10.1038/nphoton.2007.3	journal	February 2007
Terahertz quantum-cascade-laser source based on intracavity difference-frequency generation Belkin, Mikhail A.; Capasso, Federico; Belyanin, Alexey Nature Photonics, Vol. 1, Issue 5 https://doi.org/10.1038/nphoton.2007.70	journal	May 2007
Octave-spanning semiconductor laser Rösch, Markus; Scalari, Giacomo; Beck, Mattias Nature Photonics, Vol. 9, Issue 1 https://doi.org/10.1038/nphoton.2014.279	journal	November 2014
Terahertz laser frequency combs Burghoff, David; Kao, Tsung-Yu; Han, Ningren Nature Photonics, Vol. 8, Issue 6 https://doi.org/10.1038/nphoton.2014.85	journal	May 2014
Silicon-chip-based mid-infrared dual-comb spectroscopy Yu, Mengjie; Okawachi, Yoshitomo; Griffith, Austin G. Nature Communications, Vol. 9, Issue 1 https://doi.org/10.1038/s41467-018-04350-1	journal	May 2018
High-coherence mid-infrared dual-comb spectroscopy spanning 2.6 to 5.2 μm Ycas, Gabriel; Giorgetta, Fabrizio R.; Baumann, Esther Nature Photonics, Vol. 12, Issue 4 https://doi.org/10.1038/s41566-018-0114-7	journal	March 2018
Massively parallel sensing of trace molecules and their isotopologues with broadband subharmonic mid-infrared frequency combs Muraviev, A. V.; Smolski, V. O.; Loparo, Z. E. Nature Photonics, Vol. 12, Issue 4 https://doi.org/10.1038/s41566-018-0135-2	journal	March 2018
Adaptive sampling dual terahertz comb spectroscopy using dual free-running femtosecond lasers Yasui, Takeshi; Ichikawa, Ryuji; Hsieh, Yi-Da Scientific Reports, Vol. 5, Issue 1 https://doi.org/10.1038/srep10786	journal	June 2015
Real-time terahertz imaging over a standoff distance (>25meters) Lee, Alan W. M.; Qin, Qi; Kumar, Sushil Applied Physics Letters, Vol. 89, Issue 14 https://doi.org/10.1063/1.2360210	journal	October 2006
Mid-infrared multiheterodyne spectroscopy with phase-locked quantum cascade lasers Westberg, J.; Sterczewski, L. A.; Wysocki, G. Applied Physics Letters, Vol. 110, Issue 14 https://doi.org/10.1063/1.4979825	journal	April 2017
Dual comb operation of λ ∼ 8.2 μ m quantum cascade laser frequency comb with 1 W optical power Jouy, P.; Wolf, J. M.; Bidaux, Y. Applied Physics Letters, Vol. 111, Issue 14 https://doi.org/10.1063/1.4985102	journal	October 2017
Terahertz Pulsed Imaging of Human Breast Tumors Fitzgerald, Anthony J.; Wallace, Vincent P.; Jimenez-Linan, Mercedes Radiology, Vol. 239, Issue 2 https://doi.org/10.1148/radiol.2392041315	journal	May 2006
Recent advances in terahertz technology for biomedical applications Sun, Qiushuo; He, Yuezhi; Liu, Kai Quantitative Imaging in Medicine and Surgery, Vol. 7, Issue 3 https://doi.org/10.21037/qims.2017.06.02	journal	June 2017
Microelectromechanical control of the state of quantum cascade laser frequency combs Burghoff, David; Han, Ningren; Kapsalidis, Filippos Applied Physics Letters, Vol. 115, Issue 2 https://doi.org/10.1063/1.5098086	journal	July 2019
Direct hyperspectral dual-comb imaging Martín-Mateos, Pedro; Khan, Farid Ullah; Bonilla-Manrique, Oscar Elías Optica, Vol. 7, Issue 3 https://doi.org/10.1364/optica.382887	journal	January 2020
RF Injection of THz QCL Combs at 80 K Emitting over 700 GHz Spectral Bandwidth Forrer, Andres; Bosco, Lorenzo; Beck, Mattias Photonics, Vol. 7, Issue 1 https://doi.org/10.3390/photonics7010009	journal	January 2020

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