skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: An ensemble of lipoxygenase structures reveals novel conformations of the Fe coordination sphere

Authors:
; ; ; ; ;  [1]
  1. LSU
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Org.:
National Institutes of Health (NIH)
OSTI Identifier:
1515293
Resource Type:
Journal Article
Journal Name:
Protein Sci.
Additional Journal Information:
Journal Volume: 28; Journal Issue: (5) ; 05, 2019
Country of Publication:
United States
Language:
ENGLISH

Citation Formats

Pakhomova, Svetlana, Boeglin, William E., Neau, David B., Bartlett, Sue G., Brash, Alan R., Newcomer, Marcia E., Cornell), and Vanderbilt-MED). An ensemble of lipoxygenase structures reveals novel conformations of the Fe coordination sphere. United States: N. p., 2019. Web. doi:10.1002/pro.3602.
Pakhomova, Svetlana, Boeglin, William E., Neau, David B., Bartlett, Sue G., Brash, Alan R., Newcomer, Marcia E., Cornell), & Vanderbilt-MED). An ensemble of lipoxygenase structures reveals novel conformations of the Fe coordination sphere. United States. doi:10.1002/pro.3602.
Pakhomova, Svetlana, Boeglin, William E., Neau, David B., Bartlett, Sue G., Brash, Alan R., Newcomer, Marcia E., Cornell), and Vanderbilt-MED). Mon . "An ensemble of lipoxygenase structures reveals novel conformations of the Fe coordination sphere". United States. doi:10.1002/pro.3602.
@article{osti_1515293,
title = {An ensemble of lipoxygenase structures reveals novel conformations of the Fe coordination sphere},
author = {Pakhomova, Svetlana and Boeglin, William E. and Neau, David B. and Bartlett, Sue G. and Brash, Alan R. and Newcomer, Marcia E. and Cornell) and Vanderbilt-MED)},
abstractNote = {},
doi = {10.1002/pro.3602},
journal = {Protein Sci.},
number = (5) ; 05, 2019,
volume = 28,
place = {United States},
year = {2019},
month = {5}
}

Works referenced in this record:

The Oxylipin Pathways: Biochemistry and Function
journal, April 2018


Crystal Structure of Manganese Lipoxygenase of the Rice Blast Fungus Magnaporthe oryzae
journal, January 2016

  • Wennman, Anneli; Oliw, Ernst H.; Karkehabadi, Saeid
  • Journal of Biological Chemistry, Vol. 291, Issue 15
  • DOI: 10.1074/jbc.M115.707380

An Iron 13S-Lipoxygenase with an α-Linolenic Acid Specific Hydroperoxidase Activity from Fusarium oxysporum
journal, May 2013


Conformational flexibility in mammalian 15S‐lipoxygenase: Reinterpretation of the crystallographic data
journal, January 2008

  • Choi, Jongkeun; Chon, Jae Kyung; Kim, Sangsoo
  • Proteins: Structure, Function, and Bioinformatics, Vol. 70, Issue 3
  • DOI: 10.1002/prot.21590

The opportunistic pathogen Pseudomonas aeruginosa carries a secretable arachidonate 15-lipoxygenase
journal, February 2004

  • Vance, Russell E.; Hong, Song; Gronert, Karsten
  • Proceedings of the National Academy of Sciences, Vol. 101, Issue 7
  • DOI: 10.1073/pnas.0307308101

Coot model-building tools for molecular graphics
journal, November 2004

  • Emsley, Paul; Cowtan, Kevin
  • Acta Crystallographica Section D Biological Crystallography, Vol. 60, Issue 12, p. 2126-2132
  • DOI: 10.1107/S0907444904019158

A fungal catalase reacts selectively with the 13 S fatty acid hydroperoxide products of the adjacent lipoxygenase gene and exhibits 13 S -hydroperoxide-dependent peroxidase activity
journal, July 2017

  • Teder, Tarvi; Boeglin, William E.; Schneider, Claus
  • Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Vol. 1862, Issue 7
  • DOI: 10.1016/j.bbalip.2017.03.011

The structural basis for specificity in lipoxygenase catalysis: Specificity in Lipoxygenases
journal, January 2015

  • Newcomer, Marcia E.; Brash, Alan R.
  • Protein Science, Vol. 24, Issue 3
  • DOI: 10.1002/pro.2626

The structure of mammalian 15-lipoxygenase reveals similarity to the lipases and the determinants of substrate specificity
journal, December 1997

  • Gillmor, Sarah A.; Villaseñor, Armando; Fletterick, Robert
  • Nature Structural Biology, Vol. 4, Issue 12
  • DOI: 10.1038/nsb1297-1003

Oxylipins in fungi: Fungal oxylipins
journal, February 2011


Fluctuations of an Exposed π-Helix Involved in Lipoxygenase Substrate Recognition
journal, July 2014

  • Bradshaw, Miles D.; Gaffney, Betty J.
  • Biochemistry, Vol. 53, Issue 31
  • DOI: 10.1021/bi500768c

5-Lipoxygenase, a key enzyme for leukotriene biosynthesis in health and disease
journal, April 2015

  • Rådmark, Olof; Werz, Oliver; Steinhilber, Dieter
  • Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Vol. 1851, Issue 4
  • DOI: 10.1016/j.bbalip.2014.08.012

Crystal Structure of a Lipoxygenase in Complex with Substrate: THE ARACHIDONIC ACID-BINDING SITE OF 8R-LIPOXYGENASE
journal, September 2014

  • Neau, David B.; Bender, Gunes; Boeglin, William E.
  • Journal of Biological Chemistry, Vol. 289, Issue 46
  • DOI: 10.1074/jbc.M114.599662

Systematics of key phytopathogenic Fusarium species: current status and future challenges
journal, March 2014

  • Aoki, Takayuki; O’Donnell, Kerry; Geiser, David M.
  • Journal of General Plant Pathology, Vol. 80, Issue 3
  • DOI: 10.1007/s10327-014-0509-3

A single active site residue directs oxygenation stereospecificity in lipoxygenases: Stereocontrol is linked to the position of oxygenation
journal, October 2004

  • Coffa, G.; Brash, A. R.
  • Proceedings of the National Academy of Sciences, Vol. 101, Issue 44
  • DOI: 10.1073/pnas.0406727101

Oxylipins from both pathogen and host antagonize jasmonic acid-mediated defence via the 9-lipoxygenase pathway in Fusarium verticillioides infection of maize
journal, July 2018

  • Battilani, Paola; Lanubile, Alessandra; Scala, Valeria
  • Molecular Plant Pathology, Vol. 19, Issue 9
  • DOI: 10.1111/mpp.12690

Lipoxygenase 2 from Cyanothece sp. controls dioxygen insertion by steric shielding and substrate fixation
journal, May 2017


A primary determinant for lipoxygenase positional specificity
journal, November 1991

  • Sloane, David L.; Leung, Regina; Craik, Charles S.
  • Nature, Vol. 354, Issue 6349
  • DOI: 10.1038/354149a0

Crystal Structure of Soybean Lipoxygenase L-1 at 1.4 Å Resolution ,
journal, January 1996

  • Minor, Wladek; Steczko, Janusz; Stec, Boguslaw
  • Biochemistry, Vol. 35, Issue 33
  • DOI: 10.1021/bi960576u

The CCP4 suite programs for protein crystallography
journal, September 1994


The Formation of threo-11-Hydroxy-trans-12: 13-epoxy-9-cis-octadecenoic Acid by Enzymic Isomerisation of 13-l-Hydroperoxy-9-cis,11-trans-octadecadienoic Acid by Soybean Lipoxygenase-1
journal, February 1976


Inference of Macromolecular Assemblies from Crystalline State
journal, September 2007


The Structure of Human 15-Lipoxygenase-2 with a Substrate Mimic
journal, February 2014

  • Kobe, Matthew J.; Neau, David B.; Mitchell, Caitlin E.
  • Journal of Biological Chemistry, Vol. 289, Issue 12
  • DOI: 10.1074/jbc.M113.543777

Structure and interaction with phospholipids of a prokaryotic lipoxygenase from Pseudomonas aeruginosa
journal, December 2013

  • Garreta, Albert; Val-Moraes, Silvana P.; García-Fernández, Queralt
  • The FASEB Journal, Vol. 27, Issue 12
  • DOI: 10.1096/fj.13-235952

Crystal structure of a lipoxygenase from Cyanothece sp. may reveal novel features for substrate acquisition
journal, December 2015

  • Newie, Julia; Andreou, Alexandra; Neumann, Piotr
  • Journal of Lipid Research, Vol. 57, Issue 2
  • DOI: 10.1194/jlr.M064980

Production of cross-kingdom oxylipins by pathogenic fungi: An update on their role in development and pathogenicity
journal, February 2016


Changes in the Iron Coordination Sphere of Fe(II) Lipoxygenase-1 from Soybeans upon Binding of Linoleate or Oleate
journal, July 1995