skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Inducing selectivity and chirality in group IV metal coordination with high-denticity hydroxypyridinones

Abstract

Hydroxypyridinone ligand 3,4,3-LI(1,2-HOPO) exhibits remarkable charge-based selectivity for octacoordinated tetravalent cations, forming stable chiral complexes over a very broad pH range.

Authors:
ORCiD logo [1]; ORCiD logo [2]; ORCiD logo [3]
  1. Chemical Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, USA
  2. Chemical Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, USA, Department of Chemistry
  3. Chemical Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, USA, Department of Nuclear Engineering
Publication Date:
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)
OSTI Identifier:
1513038
Grant/Contract Number:  
AC02-05CH11231
Resource Type:
Journal Article: Publisher's Accepted Manuscript
Journal Name:
Dalton Transactions
Additional Journal Information:
Journal Name: Dalton Transactions Journal Volume: 48 Journal Issue: 23; Journal ID: ISSN 1477-9226
Publisher:
Royal Society of Chemistry (RSC)
Country of Publication:
United Kingdom
Language:
English

Citation Formats

Deblonde, Gauthier J. -P., Lohrey, Trevor D., and Abergel, Rebecca J. Inducing selectivity and chirality in group IV metal coordination with high-denticity hydroxypyridinones. United Kingdom: N. p., 2019. Web. doi:10.1039/C9DT01031A.
Deblonde, Gauthier J. -P., Lohrey, Trevor D., & Abergel, Rebecca J. Inducing selectivity and chirality in group IV metal coordination with high-denticity hydroxypyridinones. United Kingdom. doi:10.1039/C9DT01031A.
Deblonde, Gauthier J. -P., Lohrey, Trevor D., and Abergel, Rebecca J. Tue . "Inducing selectivity and chirality in group IV metal coordination with high-denticity hydroxypyridinones". United Kingdom. doi:10.1039/C9DT01031A.
@article{osti_1513038,
title = {Inducing selectivity and chirality in group IV metal coordination with high-denticity hydroxypyridinones},
author = {Deblonde, Gauthier J. -P. and Lohrey, Trevor D. and Abergel, Rebecca J.},
abstractNote = {Hydroxypyridinone ligand 3,4,3-LI(1,2-HOPO) exhibits remarkable charge-based selectivity for octacoordinated tetravalent cations, forming stable chiral complexes over a very broad pH range.},
doi = {10.1039/C9DT01031A},
journal = {Dalton Transactions},
issn = {1477-9226},
number = 23,
volume = 48,
place = {United Kingdom},
year = {2019},
month = {6}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record at 10.1039/C9DT01031A

Citation Metrics:
Cited by: 1 work
Citation information provided by
Web of Science

Save / Share:

Works referenced in this record:

Investigation of a new “N 2 S 2 O 2 ” chelating agent with high Po( iv ) affinity
journal, January 2017

  • Younes, Ali; Montavon, Gilles; Gouin, Sébastien G.
  • Chemical Communications, Vol. 53, Issue 48
  • DOI: 10.1039/C7CC03198J

The ionic radii of Rf4+, Db5+ and Sg6+
journal, January 2000


Production of 177Lu for Targeted Radionuclide Therapy: Available Options
journal, February 2015

  • Dash, Ashutosh; Pillai, Maroor Raghavan Ambikalmajan; Knapp, Furn F.
  • Nuclear Medicine and Molecular Imaging, Vol. 49, Issue 2
  • DOI: 10.1007/s13139-014-0315-z

Redox behavior of Ce(IV)/Ce(III) in the presence of nitrilotriacetic acid: A surrogate study for An(IV)/An(III) redox behavior
journal, January 2010

  • Suzuki, Yoshinori; Nankawa, T.; Francis, Arokiasamy J.
  • Radiochimica Acta, Vol. 98, Issue 7
  • DOI: 10.1524/ract.2010.1735

Understanding Stability Trends along the Lanthanide Series
journal, February 2014

  • Regueiro-Figueroa, Martín; Esteban-Gómez, David; de Blas, Andrés
  • Chemistry - A European Journal, Vol. 20, Issue 14
  • DOI: 10.1002/chem.201304469

A short history of SHELX
journal, December 2007

  • Sheldrick, George M.
  • Acta Crystallographica Section A Foundations of Crystallography, Vol. 64, Issue 1, p. 112-122
  • DOI: 10.1107/S0108767307043930

Specific sequestering agents for the actinides. 16. Synthesis and initial biological testing of polydentate oxohydroxypyridinecarboxylate ligands
journal, January 1988

  • White, David L.; Durbin, Patricia W.; Jeung, Nylan
  • Journal of Medicinal Chemistry, Vol. 31, Issue 1, p. 11-18
  • DOI: 10.1021/jm00396a005

WinGX and ORTEP for Windows : an update
journal, July 2012


Bond Covalency and Oxidation State of Actinide Ions Complexed with Therapeutic Chelating Agent 3,4,3-LI(1,2-HOPO)
journal, April 2018


New Insights into Structure and Luminescence of Eu III and Sm III Complexes of the 3,4,3-LI(1,2-HOPO) Ligand
journal, February 2015

  • Daumann, Lena J.; Tatum, David S.; Snyder, Benjamin E. R.
  • Journal of the American Chemical Society, Vol. 137, Issue 8
  • DOI: 10.1021/ja5116524

Revised effective ionic radii and systematic studies of interatomic distances in halides and chalcogenides
journal, September 1976


Solution thermodynamic evaluation of hydroxypyridinonate chelators 3,4,3-LI(1,2-HOPO) and 5-LIO(Me-3,2-HOPO) for UO 2 (VI) and Th(IV) decorporation
journal, June 2013

  • Sturzbecher-Hoehne, M.; Deblonde, G. J. -P.; Abergel, R. J.
  • Radiochimica Acta, Vol. 101, Issue 6
  • DOI: 10.1524/ract.2013.2047

Separation of zirconium and hafnium using Diphonix® chelating ion-exchange resin
journal, February 2009


Hafnium-Based Contrast Agents for X-ray Computed Tomography
journal, April 2017


Potential radiopharmaceuticals labeled with titanium-45
journal, January 1991

  • Ishiwata, Kiichi; Ido, Tatsuo; Monma, Minoru
  • International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, Vol. 42, Issue 8
  • DOI: 10.1016/0883-2889(91)90173-X

Highly Luminescent and Stable Hydroxypyridinonate Complexes: A Step Towards New Curium Decontamination Strategies
journal, July 2014

  • Sturzbecher-Hoehne, Manuel; Kullgren, Birgitta; Jarvis, Erin E.
  • Chemistry - A European Journal, Vol. 20, Issue 32
  • DOI: 10.1002/chem.201402103

Rational Design of Sequestering Agents for Plutonium and Other Actinides
journal, November 2003

  • Gorden, Anne E. V.; Xu, Jide; Raymond, Kenneth N.
  • Chemical Reviews, Vol. 103, Issue 11
  • DOI: 10.1021/cr990114x

Aqueous Complexation of Thorium(IV), Uranium(IV), Neptunium(IV), Plutonium(III/IV), and Cerium(III/IV) with DTPA
journal, April 2012

  • Brown, M. Alex; Paulenova, Alena; Gelis, Artem V.
  • Inorganic Chemistry, Vol. 51, Issue 14
  • DOI: 10.1021/ic300757k

Titanium(IV) Complexes with N , N ′-Dialkyl-2,3-dihydroxyterephthalamides and 1-Hydroxy-2(1 H )-pyridinone as Siderophore and Tunichrome Analogues
journal, November 2009

  • Uppal, Ritika; Israel, Hayley P.; Incarvito, Christopher D.
  • Inorganic Chemistry, Vol. 48, Issue 22
  • DOI: 10.1021/ic901177c

3,4,3-LI(1,2-HOPO): In vitro formation of highly stable lanthanide complexes translates into efficacious in vivo europium decorporation
journal, January 2011

  • Sturzbecher-Hoehne, Manuel; Ng Pak Leung, Clara; D'Aléo, Anthony
  • Dalton Transactions, Vol. 40, Issue 33
  • DOI: 10.1039/c1dt10840a

Intramolecular sensitization of americium luminescence in solution: shining light on short-lived forbidden 5f transitions
journal, January 2016

  • Sturzbecher-Hoehne, M.; Yang, P.; D'Aléo, A.
  • Dalton Transactions, Vol. 45, Issue 24
  • DOI: 10.1039/C6DT00328A

Prediction of some thermodynamic properties of selected compounds of element 104
journal, September 1991

  • Johnson, Elijah; Fricke, B.
  • The Journal of Physical Chemistry, Vol. 95, Issue 18
  • DOI: 10.1021/j100171a067

p -SCN-Bn-HOPO: A Superior Bifunctional Chelator for 89 Zr ImmunoPET
journal, November 2015


Hydroxypyridinonate Complex Stability of Group (IV) Metals and Tetravalent f-Block Elements: The Key to the Next Generation of Chelating Agents for Radiopharmaceuticals
journal, March 2015


A 44Ti/44Sc radionuclide generator for potential application of 44Sc-based PET-radiopharmaceuticals
journal, January 2010

  • Filosofov, D. V.; Loktionova, N. S.; Rösch, Frank
  • Radiochimica Acta, Vol. 98, Issue 3
  • DOI: 10.1524/ract.2010.1701

Characterization of a Novel Hafnium-Based X-ray Contrast Agent
journal, January 2016


44 Sc: An Attractive Isotope for Peptide-Based PET Imaging
journal, July 2014

  • Hernandez, Reinier; Valdovinos, Hector F.; Yang, Yunan
  • Molecular Pharmaceutics, Vol. 11, Issue 8
  • DOI: 10.1021/mp500343j

Cymothoe sangaris”:  An Extremely Stable and Highly Luminescent 1,2-Hydroxypyridinonate Chelate of Eu(III)
July 2006

  • Moore, Evan G.; Xu, Jide; Jocher, Christoph J.
  • Journal of the American Chemical Society, Vol. 128, Issue 33, p. 10648-10649
  • DOI: 10.1021/ja062597+

GLEE, a new computer program for glass electrode calibration
journal, January 2000


Mercury : visualization and analysis of crystal structures
journal, May 2006

  • Macrae, Clare F.; Edgington, Paul R.; McCabe, Patrick
  • Journal of Applied Crystallography, Vol. 39, Issue 3
  • DOI: 10.1107/S002188980600731X

Ti(IV) and the Siderophore Desferrioxamine B: A Tight Complex Has Biological and Environmental Implications
journal, January 2017


Toxic heavy metal – Pb, Cd, Sn – complexation by the octadentate hydroxypyridinonate ligand archetype 3,4,3-LI(1,2-HOPO)
journal, January 2018

  • Deblonde, Gauthier J. -P.; Lohrey, Trevor D.; An, Dahlia D.
  • New Journal of Chemistry, Vol. 42, Issue 10
  • DOI: 10.1039/C7NJ04559J

From early prophylaxis to delayed treatment: Establishing the plutonium decorporation activity window of hydroxypyridinonate chelating agents
journal, April 2017

  • An, Dahlia D.; Kullgren, Birgitta; Jarvis, Erin E.
  • Chemico-Biological Interactions, Vol. 267
  • DOI: 10.1016/j.cbi.2016.03.034

Alternative Chelator for 89 Zr Radiopharmaceuticals: Radiolabeling and Evaluation of 3,4,3-(LI-1,2-HOPO)
journal, December 2013

  • Deri, Melissa A.; Ponnala, Shashikanth; Zeglis, Brian M.
  • Journal of Medicinal Chemistry, Vol. 57, Issue 11
  • DOI: 10.1021/jm500389b

Evaluating the potential of chelation therapy to prevent and treat gadolinium deposition from MRI contrast agents
journal, March 2018


Chelation and stabilization of berkelium in oxidation state +IV
journal, April 2017

  • Deblonde, Gauthier J. -P.; Sturzbecher-Hoehne, Manuel; Rupert, Peter B.
  • Nature Chemistry, Vol. 9, Issue 9
  • DOI: 10.1038/nchem.2759

Optimization of the Sensitization Process and Stability of Octadentate Eu(III) 1,2-HOPO Complexes
journal, July 2015