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Title: In Vivo Brain Plaque and Tangle Burden Mediates the Association Between Diastolic Blood Pressure and Cognitive Functioning in Nondemented Adults

Abstract

OBJECTIVE Growing evidence supports an association among increased blood pressure and: (a) poor cognitive performance in older adults, and (b) various biomarkers of increased Alzheimer's disease (AD) neuropathology. The objective of this study was to determine whether systolic blood pressure (SBP) and diastolic blood pressure (DBP) were significantly associated with cognitive functioning in non-demented adults, and to examine in vivo AD pathology as a possible mediator of this association. METHODS Positron emission tomography (PET) scans with 2-(1-{6-[(2-[F-18]fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)malononitrile (FDDNP) provide in vivo measurements of plaque and tangle burden. A total of 101 non-demented older subjects with blood pressure data and FDDNP-PET scans were drawn from a larger study of predictors of cognitive decline. A neuropsychological test battery was used to compute "global cognitive scores" (averaged across five key domains), which served as an index of general cognitive functioning. RESULTS Higher DBP (but not SBP) was significantly associated with lower cognitive scores, controlling for age, sex, antihypertensive medication use, and ApoE genotype (η2 = 0.06). However, this relationship was no longer significant after introducing FDDNP-PET binding as an additional covariate in the statistical models. In vivo plaque and tangle burden accounted for over 30% of the observed association between higher DBP andmore » poorer cognitive performance. CONCLUSIONS By indicating a mediation of the relationship between DBP and cognitive functioning by FDDNP-PET binding, this study advances our understanding of some potential predictors of cognitive decline in non-demented adults, and underscores the importance of devising early multimodal interventions to more effectively combat degenerative brain disorders.« less

Authors:
 [1];  [1];  [1];  [1];  [1];  [1];  [1];  [1];  [1]
  1. Univ. of California, Los Angeles, CA (United States)
Publication Date:
Research Org.:
Univ. of California, Los Angeles, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1511835
Alternate Identifier(s):
OSTI ID: 1549967
Grant/Contract Number:  
FC03-87ER60615; FC03-87-ER60615
Resource Type:
Journal Article: Accepted Manuscript
Journal Name:
The American Journal of Geriatric Psychiatry
Additional Journal Information:
Journal Volume: 26; Journal Issue: 1; Journal ID: ISSN 1064-7481
Publisher:
American Association for Geriatric Psychiatry - Elsevier
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; FDDNP-PET; age-related cognitive decline; diastolic blood pressure; plaques; tangles

Citation Formats

Roussotte, Florence F., Siddarth, Prabha, Merrill, David A., Narr, Katherine L., Ercoli, Linda M., Martinez, Jacqueline, Emerson, Natacha D., Barrio, Jorge R., and Small, Gary W. In Vivo Brain Plaque and Tangle Burden Mediates the Association Between Diastolic Blood Pressure and Cognitive Functioning in Nondemented Adults. United States: N. p., 2017. Web. doi:10.1016/j.jagp.2017.09.001.
Roussotte, Florence F., Siddarth, Prabha, Merrill, David A., Narr, Katherine L., Ercoli, Linda M., Martinez, Jacqueline, Emerson, Natacha D., Barrio, Jorge R., & Small, Gary W. In Vivo Brain Plaque and Tangle Burden Mediates the Association Between Diastolic Blood Pressure and Cognitive Functioning in Nondemented Adults. United States. doi:10.1016/j.jagp.2017.09.001.
Roussotte, Florence F., Siddarth, Prabha, Merrill, David A., Narr, Katherine L., Ercoli, Linda M., Martinez, Jacqueline, Emerson, Natacha D., Barrio, Jorge R., and Small, Gary W. Fri . "In Vivo Brain Plaque and Tangle Burden Mediates the Association Between Diastolic Blood Pressure and Cognitive Functioning in Nondemented Adults". United States. doi:10.1016/j.jagp.2017.09.001. https://www.osti.gov/servlets/purl/1511835.
@article{osti_1511835,
title = {In Vivo Brain Plaque and Tangle Burden Mediates the Association Between Diastolic Blood Pressure and Cognitive Functioning in Nondemented Adults},
author = {Roussotte, Florence F. and Siddarth, Prabha and Merrill, David A. and Narr, Katherine L. and Ercoli, Linda M. and Martinez, Jacqueline and Emerson, Natacha D. and Barrio, Jorge R. and Small, Gary W.},
abstractNote = {OBJECTIVE Growing evidence supports an association among increased blood pressure and: (a) poor cognitive performance in older adults, and (b) various biomarkers of increased Alzheimer's disease (AD) neuropathology. The objective of this study was to determine whether systolic blood pressure (SBP) and diastolic blood pressure (DBP) were significantly associated with cognitive functioning in non-demented adults, and to examine in vivo AD pathology as a possible mediator of this association. METHODS Positron emission tomography (PET) scans with 2-(1-{6-[(2-[F-18]fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)malononitrile (FDDNP) provide in vivo measurements of plaque and tangle burden. A total of 101 non-demented older subjects with blood pressure data and FDDNP-PET scans were drawn from a larger study of predictors of cognitive decline. A neuropsychological test battery was used to compute "global cognitive scores" (averaged across five key domains), which served as an index of general cognitive functioning. RESULTS Higher DBP (but not SBP) was significantly associated with lower cognitive scores, controlling for age, sex, antihypertensive medication use, and ApoE genotype (η2 = 0.06). However, this relationship was no longer significant after introducing FDDNP-PET binding as an additional covariate in the statistical models. In vivo plaque and tangle burden accounted for over 30% of the observed association between higher DBP and poorer cognitive performance. CONCLUSIONS By indicating a mediation of the relationship between DBP and cognitive functioning by FDDNP-PET binding, this study advances our understanding of some potential predictors of cognitive decline in non-demented adults, and underscores the importance of devising early multimodal interventions to more effectively combat degenerative brain disorders.},
doi = {10.1016/j.jagp.2017.09.001},
journal = {The American Journal of Geriatric Psychiatry},
issn = {1064-7481},
number = 1,
volume = 26,
place = {United States},
year = {2017},
month = {9}
}

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