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Title: Systemic signaling contributes to the unfolded protein response of the plant endoplasmic reticulum

Abstract

The unfolded protein response (UPR) of the endoplasmic reticulum constitutes a conserved and essential cytoprotective pathway designed to survive biotic and abiotic stresses that alter the proteostasis of the endoplasmic reticulum. The UPR is typically considered cell-autonomous and it is yet unclear whether it can also act systemically through non-cell autonomous signaling. We have addressed this question using a genetic approach coupled with micro-grafting and a suite of molecular reporters in the model plant species Arabidopsis thaliana. We show that the UPR has a non-cell autonomous component, and we demonstrate that this is partially mediated by the intercellular movement of the UPR transcription factor bZIP60 facilitating systemic UPR signaling. Therefore, in multicellular eukaryotes such as plants, non-cell autonomous UPR signaling relies on the systemic movement of at least a UPR transcriptional modulator.

Authors:
 [1];  [1];  [1];  [1];  [1];  [1]
  1. Michigan State Univ., East Lansing, MI (United States)
Publication Date:
Research Org.:
Univ. of Wisconsin, Madison, WI (United States); Michigan State Univ., East Lansing, MI (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22); USDOE Office of Science (SC), Biological and Environmental Research (BER) (SC-23)
OSTI Identifier:
1511712
Grant/Contract Number:  
FC02-07ER64494; FG02-91ER20021
Resource Type:
Journal Article: Accepted Manuscript
Journal Name:
Nature Communications
Additional Journal Information:
Journal Volume: 9; Journal Issue: 1; Journal ID: ISSN 2041-1723
Publisher:
Nature Publishing Group
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Lai, Ya-Shiuan, Stefano, Giovanni, Zemelis-Durfee, Starla, Ruberti, Cristina, Gibbons, Lizzie, and Brandizzi, Federica. Systemic signaling contributes to the unfolded protein response of the plant endoplasmic reticulum. United States: N. p., 2018. Web. doi:10.1038/s41467-018-06289-9.
Lai, Ya-Shiuan, Stefano, Giovanni, Zemelis-Durfee, Starla, Ruberti, Cristina, Gibbons, Lizzie, & Brandizzi, Federica. Systemic signaling contributes to the unfolded protein response of the plant endoplasmic reticulum. United States. doi:10.1038/s41467-018-06289-9.
Lai, Ya-Shiuan, Stefano, Giovanni, Zemelis-Durfee, Starla, Ruberti, Cristina, Gibbons, Lizzie, and Brandizzi, Federica. Tue . "Systemic signaling contributes to the unfolded protein response of the plant endoplasmic reticulum". United States. doi:10.1038/s41467-018-06289-9. https://www.osti.gov/servlets/purl/1511712.
@article{osti_1511712,
title = {Systemic signaling contributes to the unfolded protein response of the plant endoplasmic reticulum},
author = {Lai, Ya-Shiuan and Stefano, Giovanni and Zemelis-Durfee, Starla and Ruberti, Cristina and Gibbons, Lizzie and Brandizzi, Federica},
abstractNote = {The unfolded protein response (UPR) of the endoplasmic reticulum constitutes a conserved and essential cytoprotective pathway designed to survive biotic and abiotic stresses that alter the proteostasis of the endoplasmic reticulum. The UPR is typically considered cell-autonomous and it is yet unclear whether it can also act systemically through non-cell autonomous signaling. We have addressed this question using a genetic approach coupled with micro-grafting and a suite of molecular reporters in the model plant species Arabidopsis thaliana. We show that the UPR has a non-cell autonomous component, and we demonstrate that this is partially mediated by the intercellular movement of the UPR transcription factor bZIP60 facilitating systemic UPR signaling. Therefore, in multicellular eukaryotes such as plants, non-cell autonomous UPR signaling relies on the systemic movement of at least a UPR transcriptional modulator.},
doi = {10.1038/s41467-018-06289-9},
journal = {Nature Communications},
issn = {2041-1723},
number = 1,
volume = 9,
place = {United States},
year = {2018},
month = {9}
}

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Works referenced in this record:

Floral dip: a simplified method for Agrobacterium-mediated transformation of Arabidopsis thaliana
journal, December 1998