Perovskite nickelates as bio-electronic interfaces

Journal Article · Wed Apr 10 00:00:00 EDT 2019 · Nature Communications

DOI:https://doi.org/10.1038/s41467-019-09660-6· OSTI ID:1508370

Zhang, Hai-Tian; Zuo, Fan; Li, Feiran; Chan, Henry; Wu, Qiuyu; Zhang, Zhan; Narayanan, Badri; Ramadoss, Khousik; Chakraborty, Indranil; Saha, Gobinda; Kamath, Ganesh; Roy, Kaushik; Zhou, Hua; Chubykin, Alexander A.; Choi, Jong Hyun; Ramanathan, Shriram

Functional interfaces between electronics and biological matter are essential to diverse fields including health sciences and bio-engineering. Here, we report the discovery of spontaneous (no external energy input) hydrogen transfer from biological glucose reactions into SmNiO₃, an archetypal perovskite quantum material. The enzymatic oxidation of glucose is monitored down to ~5 × 10–16 M concentration via hydrogen transfer to the nickelate lattice. The hydrogen atoms donate electrons to the Ni d orbital and induce electron localization through strong electron correlations. By enzyme specific modification, spontaneous transfer of hydrogen from the neurotransmitter dopamine can be monitored in physiological media. We then directly interface an acute mouse brain slice onto the nickelate devices and demonstrate measurement of neurotransmitter release upon electrical stimulation of the striatum region. These results open up avenues for use of emergent physics present in quantum materials in trace detection and conveyance of bio-matter, bio-chemical sciences, and brain-machine interfaces.

• Research Organization: Argonne National Laboratory (ANL), Argonne, IL (United States)
• Sponsoring Organization: USDOE Office of Science - National Energy Research Scientific Computing Center (NERSC); Purdue University; US Department of the Navy, Office of Naval Research (ONR); National Science Foundation (NSF); USDOE Office of Science - Office of Basic Energy Sciences - Scientific User Facilities Division
• DOE Contract Number: AC02-06CH11357
• OSTI ID: 1508370
• Journal Information: Nature Communications, Vol. 10, Issue 1; ISSN 2041-1723
• Publisher: Nature Publishing Group
• Country of Publication: United States
• Language: English