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Title: Perovskite nickelates as bio-electronic interfaces

Abstract

Functional interfaces between electronics and biological matter are essential to diverse fields including health sciences and bio-engineering. Here, we report the discovery of spontaneous (no external energy input) hydrogen transfer from biological glucose reactions into SmNiO 3, an archetypal perovskite quantum material. The enzymatic oxidation of glucose is monitored down to ~5 × 10–16 M concentration via hydrogen transfer to the nickelate lattice. The hydrogen atoms donate electrons to the Ni d orbital and induce electron localization through strong electron correlations. By enzyme specific modification, spontaneous transfer of hydrogen from the neurotransmitter dopamine can be monitored in physiological media. We then directly interface an acute mouse brain slice onto the nickelate devices and demonstrate measurement of neurotransmitter release upon electrical stimulation of the striatum region. These results open up avenues for use of emergent physics present in quantum materials in trace detection and conveyance of bio-matter, bio-chemical sciences, and brain-machine interfaces.

Authors:
; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States)
Sponsoring Org.:
USDOE Office of Science - National Energy Research Scientific Computing Center (NERSC); Purdue University; US Department of the Navy, Office of Naval Research (ONR); National Science Foundation (NSF); USDOE Office of Science - Office of Basic Energy Sciences - Scientific User Facilities Division
OSTI Identifier:
1508370
DOE Contract Number:  
AC02-06CH11357
Resource Type:
Journal Article
Journal Name:
Nature Communications
Additional Journal Information:
Journal Volume: 10; Journal Issue: 1; Journal ID: ISSN 2041-1723
Publisher:
Nature Publishing Group
Country of Publication:
United States
Language:
English

Citation Formats

Zhang, Hai-Tian, Zuo, Fan, Li, Feiran, Chan, Henry, Wu, Qiuyu, Zhang, Zhan, Narayanan, Badri, Ramadoss, Khousik, Chakraborty, Indranil, Saha, Gobinda, Kamath, Ganesh, Roy, Kaushik, Zhou, Hua, Chubykin, Alexander A., Sankaranarayanan, Subramanian K. R. S., Choi, Jong Hyun, and Ramanathan, Shriram. Perovskite nickelates as bio-electronic interfaces. United States: N. p., 2019. Web. doi:10.1038/s41467-019-09660-6.
Zhang, Hai-Tian, Zuo, Fan, Li, Feiran, Chan, Henry, Wu, Qiuyu, Zhang, Zhan, Narayanan, Badri, Ramadoss, Khousik, Chakraborty, Indranil, Saha, Gobinda, Kamath, Ganesh, Roy, Kaushik, Zhou, Hua, Chubykin, Alexander A., Sankaranarayanan, Subramanian K. R. S., Choi, Jong Hyun, & Ramanathan, Shriram. Perovskite nickelates as bio-electronic interfaces. United States. doi:10.1038/s41467-019-09660-6.
Zhang, Hai-Tian, Zuo, Fan, Li, Feiran, Chan, Henry, Wu, Qiuyu, Zhang, Zhan, Narayanan, Badri, Ramadoss, Khousik, Chakraborty, Indranil, Saha, Gobinda, Kamath, Ganesh, Roy, Kaushik, Zhou, Hua, Chubykin, Alexander A., Sankaranarayanan, Subramanian K. R. S., Choi, Jong Hyun, and Ramanathan, Shriram. Wed . "Perovskite nickelates as bio-electronic interfaces". United States. doi:10.1038/s41467-019-09660-6.
@article{osti_1508370,
title = {Perovskite nickelates as bio-electronic interfaces},
author = {Zhang, Hai-Tian and Zuo, Fan and Li, Feiran and Chan, Henry and Wu, Qiuyu and Zhang, Zhan and Narayanan, Badri and Ramadoss, Khousik and Chakraborty, Indranil and Saha, Gobinda and Kamath, Ganesh and Roy, Kaushik and Zhou, Hua and Chubykin, Alexander A. and Sankaranarayanan, Subramanian K. R. S. and Choi, Jong Hyun and Ramanathan, Shriram},
abstractNote = {Functional interfaces between electronics and biological matter are essential to diverse fields including health sciences and bio-engineering. Here, we report the discovery of spontaneous (no external energy input) hydrogen transfer from biological glucose reactions into SmNiO3, an archetypal perovskite quantum material. The enzymatic oxidation of glucose is monitored down to ~5 × 10–16 M concentration via hydrogen transfer to the nickelate lattice. The hydrogen atoms donate electrons to the Ni d orbital and induce electron localization through strong electron correlations. By enzyme specific modification, spontaneous transfer of hydrogen from the neurotransmitter dopamine can be monitored in physiological media. We then directly interface an acute mouse brain slice onto the nickelate devices and demonstrate measurement of neurotransmitter release upon electrical stimulation of the striatum region. These results open up avenues for use of emergent physics present in quantum materials in trace detection and conveyance of bio-matter, bio-chemical sciences, and brain-machine interfaces.},
doi = {10.1038/s41467-019-09660-6},
journal = {Nature Communications},
issn = {2041-1723},
number = 1,
volume = 10,
place = {United States},
year = {2019},
month = {4}
}

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