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Title: Plasma lipidome reveals critical illness and recovery from human Ebola virus disease

Abstract

Ebola virus disease (EVD) often leads to severe and fatal outcomes in humans with early supportive care increasing the chances of survival. Profiling the human plasma lipidome provides insight into critical illness as well as diseased states, as lipids have essential roles as membrane structural components, signaling molecules, and energy sources. Here we show that the plasma lipidomes of EVD survivors and fatalities from Sierra Leone, infected during the 2014–2016 Ebola virus outbreak, were profoundly altered. Focusing on how lipids are associated in human plasma, while factoring in the state of critical illness, we found that lipidome changes were related to EVD outcome and could identify states of disease and recovery. Specific changes in the lipidome suggested contributions from extracellular vesicles, viremia, liver dysfunction, apoptosis, autophagy, and general critical illness, and we identified possible targets for therapies enhancing EVD survival.

Authors:
ORCiD logo; ORCiD logo; ; ; ; ; ; ; ; ;
Publication Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1506690
Report Number(s):
PNNL-SA-136689
Journal ID: ISSN 0027-8424
DOE Contract Number:  
AC05-76RL01830
Resource Type:
Journal Article
Journal Name:
Proceedings of the National Academy of Sciences of the United States of America
Additional Journal Information:
Journal Volume: 116; Journal Issue: 9; Journal ID: ISSN 0027-8424
Publisher:
National Academy of Sciences, Washington, DC (United States)
Country of Publication:
United States
Language:
English

Citation Formats

Kyle, J. E., Burnum-Johnson, K. E., Wendler, J. P., Eisfeld, A. J., Halfmann, Peter J., Watanabe, Tokiko, Sahr, Foday, Smith, R. D., Kawaoka, Y., Waters, K. M., and Metz, T. O. Plasma lipidome reveals critical illness and recovery from human Ebola virus disease. United States: N. p., 2019. Web. doi:10.1073/pnas.1815356116.
Kyle, J. E., Burnum-Johnson, K. E., Wendler, J. P., Eisfeld, A. J., Halfmann, Peter J., Watanabe, Tokiko, Sahr, Foday, Smith, R. D., Kawaoka, Y., Waters, K. M., & Metz, T. O. Plasma lipidome reveals critical illness and recovery from human Ebola virus disease. United States. doi:10.1073/pnas.1815356116.
Kyle, J. E., Burnum-Johnson, K. E., Wendler, J. P., Eisfeld, A. J., Halfmann, Peter J., Watanabe, Tokiko, Sahr, Foday, Smith, R. D., Kawaoka, Y., Waters, K. M., and Metz, T. O. Mon . "Plasma lipidome reveals critical illness and recovery from human Ebola virus disease". United States. doi:10.1073/pnas.1815356116.
@article{osti_1506690,
title = {Plasma lipidome reveals critical illness and recovery from human Ebola virus disease},
author = {Kyle, J. E. and Burnum-Johnson, K. E. and Wendler, J. P. and Eisfeld, A. J. and Halfmann, Peter J. and Watanabe, Tokiko and Sahr, Foday and Smith, R. D. and Kawaoka, Y. and Waters, K. M. and Metz, T. O.},
abstractNote = {Ebola virus disease (EVD) often leads to severe and fatal outcomes in humans with early supportive care increasing the chances of survival. Profiling the human plasma lipidome provides insight into critical illness as well as diseased states, as lipids have essential roles as membrane structural components, signaling molecules, and energy sources. Here we show that the plasma lipidomes of EVD survivors and fatalities from Sierra Leone, infected during the 2014–2016 Ebola virus outbreak, were profoundly altered. Focusing on how lipids are associated in human plasma, while factoring in the state of critical illness, we found that lipidome changes were related to EVD outcome and could identify states of disease and recovery. Specific changes in the lipidome suggested contributions from extracellular vesicles, viremia, liver dysfunction, apoptosis, autophagy, and general critical illness, and we identified possible targets for therapies enhancing EVD survival.},
doi = {10.1073/pnas.1815356116},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
issn = {0027-8424},
number = 9,
volume = 116,
place = {United States},
year = {2019},
month = {2}
}

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