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Title: Structural and kinetic basis for the selectivity of aducanumab for aggregated forms of amyloid-β

Authors:
; ; ; ; ; ; ; ; ; ; ; ORCiD logo
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Org.:
DOE - BASIC ENERGY SCIENCES
OSTI Identifier:
1506530
Resource Type:
Journal Article
Journal Name:
Scientific Reports
Additional Journal Information:
Journal Volume: 8; Journal Issue: 1; Journal ID: ISSN 2045-2322
Publisher:
Nature Publishing Group
Country of Publication:
United States
Language:
ENGLISH

Citation Formats

Arndt, Joseph W., Qian, Fang, Smith, Benjamin A., Quan, Chao, Kilambi, Krishna Praneeth, Bush, Martin W., Walz, Thomas, Pepinsky, R. Blake, Bussière, Thierry, Hamann, Stefan, Cameron, Thomas O., and Weinreb, Paul H. Structural and kinetic basis for the selectivity of aducanumab for aggregated forms of amyloid-β. United States: N. p., 2018. Web. doi:10.1038/s41598-018-24501-0.
Arndt, Joseph W., Qian, Fang, Smith, Benjamin A., Quan, Chao, Kilambi, Krishna Praneeth, Bush, Martin W., Walz, Thomas, Pepinsky, R. Blake, Bussière, Thierry, Hamann, Stefan, Cameron, Thomas O., & Weinreb, Paul H. Structural and kinetic basis for the selectivity of aducanumab for aggregated forms of amyloid-β. United States. https://doi.org/10.1038/s41598-018-24501-0
Arndt, Joseph W., Qian, Fang, Smith, Benjamin A., Quan, Chao, Kilambi, Krishna Praneeth, Bush, Martin W., Walz, Thomas, Pepinsky, R. Blake, Bussière, Thierry, Hamann, Stefan, Cameron, Thomas O., and Weinreb, Paul H. Mon . "Structural and kinetic basis for the selectivity of aducanumab for aggregated forms of amyloid-β". United States. https://doi.org/10.1038/s41598-018-24501-0.
@article{osti_1506530,
title = {Structural and kinetic basis for the selectivity of aducanumab for aggregated forms of amyloid-β},
author = {Arndt, Joseph W. and Qian, Fang and Smith, Benjamin A. and Quan, Chao and Kilambi, Krishna Praneeth and Bush, Martin W. and Walz, Thomas and Pepinsky, R. Blake and Bussière, Thierry and Hamann, Stefan and Cameron, Thomas O. and Weinreb, Paul H.},
abstractNote = {},
doi = {10.1038/s41598-018-24501-0},
url = {https://www.osti.gov/biblio/1506530}, journal = {Scientific Reports},
issn = {2045-2322},
number = 1,
volume = 8,
place = {United States},
year = {2018},
month = {4}
}

Works referenced in this record:

Molecular basis of  -amyloid oligomer recognition with a conformational antibody fragment
journal, July 2012


Shape Complementarity at Protein/Protein Interfaces
journal, December 1993


Isolation of Low-Molecular-Weight Proteins from Amyloid Plaque Fibers in Alzheimer's Disease
journal, June 1986


Do current therapeutic anti-Aβ antibodies for Alzheimer’s disease engage the target?
journal, May 2014


Crystallization and preliminary X-ray diffraction analysis of the Fab portion of the Alzheimer's disease immunotherapy candidate bapineuzumab complexed with amyloid-β
journal, February 2014


Bapineuzumab captures the N-terminus of the Alzheimer's disease amyloid-beta peptide in a helical conformation
journal, February 2013


Overview of the CCP 4 suite and current developments
journal, March 2011


The Murine Version of BAN2401 (mAb158) Selectively Reduces Amyloid-β Protofibrils in Brain and Cerebrospinal Fluid of tg-ArcSwe Mice
journal, November 2014


Structural Correlates of Antibodies Associated with Acute Reversal of Amyloid β-related Behavioral Deficits in a Mouse Model of Alzheimer Disease
journal, November 2009


Immunogenic properties of amyloid beta oligomers
journal, January 2013


Quantitative and Mechanistic Studies of Aβ Immunotherapy
journal, March 2009


Structural variation in amyloid-β fibrils from Alzheimer's disease clinical subtypes
journal, January 2017


REFMAC 5 dictionary: organization of prior chemical knowledge and guidelines for its use
journal, November 2004


Promising Targets for the Treatment of Neurodegenerative Diseases
journal, September 2015


Structural Basis of C-terminal β-Amyloid Peptide Binding by the Antibody Ponezumab for the Treatment of Alzheimer's Disease
journal, August 2012


Atomic Resolution Structure of Monomorphic Aβ 42 Amyloid Fibrils
journal, July 2016


Peripheral anti-A  antibody alters CNS and plasma A  clearance and decreases brain A  burden in a mouse model of Alzheimer's disease
journal, July 2001


Anti-ADDL antibodies differentially block oligomer binding to hippocampal neurons
journal, February 2010


What is the dominant aβ species in human brain tissue? A review
journal, January 2005


The amyloid hypothesis of Alzheimer's disease at 25 years
journal, March 2016


The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease
journal, August 2016


Aβ42 immunization in Alzheimer's disease generates Aβ N-terminal antibodies
journal, January 2005


Neurotoxicity of Amyloid  -Protein: Synaptic and Network Dysfunction
journal, March 2012


Cognitive effects of cell-derived and synthetically derived Aβ oligomers
journal, October 2011


An amyloid-β protofibril-selective antibody prevents amyloid formation in a mouse model of Alzheimer's disease
journal, December 2009


Inference of Macromolecular Assemblies from Crystalline State
journal, September 2007


Molecular basis for mid-region amyloid-β capture by leading Alzheimer's disease immunotherapies
journal, April 2015


A gentle vapor-diffusion technique for cross-linking of protein crystals for cryocrystallography
journal, February 1999


Crystal structure reveals conservation of amyloid-β conformation recognized by 3D6 following humanization to bapineuzumab
journal, January 2014


Protein-Protein Docking with Dynamic Residue Protonation States
journal, December 2014


Anti-Amyloid-β Monoclonal Antibodies for Alzheimer’s Disease: Pitfalls and Promise
journal, February 2018


Molecular basis for passive immunotherapy of Alzheimer's disease
journal, September 2007


Features and development of Coot
journal, March 2010


The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes
journal, January 2012


Aβ oligomers inhibit synapse remodelling necessary for memory consolidation
journal, December 2011


Amyloid-β and tau complexity — towards improved biomarkers and targeted therapies
journal, December 2017


A Generic Method for Design of Oligomer-Specific Antibodies
journal, March 2014


Structure of Crenezumab Complex with Aβ Shows Loss of β-Hairpin
journal, December 2016


 -Amyloid Monomers Are Neuroprotective
journal, August 2009


Aβ(1–42) fibril structure illuminates self-recognition and replication of amyloid in Alzheimer's disease
journal, May 2015


The conformational epitope for a new Aβ42 protofibril-selective antibody partially overlaps with the peptide N-terminal region
journal, November 2017


Molecular Structure of β-Amyloid Fibrils in Alzheimer’s Disease Brain Tissue
journal, September 2013


Perspectives on future Alzheimer therapies: amyloid-β protofibrils - a new target for immunotherapy with BAN2401 in Alzheimer’s disease
journal, January 2014


Monoclonal Antibodies against Aβ42 Fibrils Distinguish Multiple Aggregation State Polymorphisms in Vitro and in Alzheimer Disease Brain
journal, October 2014


Amyloid-β–Anti-Amyloid-β Complex Structure Reveals an Extended Conformation in the Immunodominant B-Cell Epitope
journal, March 2008


Alzheimer amyloid hypothesis lives on
journal, December 2016


Seeded growth of  -amyloid fibrils from Alzheimer's brain-derived fibrils produces a distinct fibril structure
journal, April 2009


CSF beta-amyloid 1-42 - what are we measuring in Alzheimer's disease?
journal, December 2014


Atomic-resolution structure of a disease-relevant Aβ(1–42) amyloid fibril
journal, July 2016