Germinal-center kinase-like kinase co-crystal structure reveals a swapped activation loop and C-terminal extension: GLK Co-crystal Structure with Aminopyrrolopyrimidine Inhibitor

Journal Article · Fri Oct 21 00:00:00 EDT 2016 · Protein Science

DOI:https://doi.org/10.1002/pro.3062· OSTI ID:1506514

Marcotte, Douglas ^[1]; Rushe, Mia ^[1]; M. Arduini, Robert ^[1]; Lukacs, Christine ^[2]; Atkins, Kateri ^[2]; Sun, Xin ^[1]; Little, Kevin ^[1]; Cullivan, Michael ^[1]; Paramasivam, Murugan ^[1]; Patterson, Thomas A. ^[1]; Hesson, Thomas ^[1]; D. McKee, Timothy ^[1]; May-Dracka, Tricia L. ^[1]; Xin, Zhili ^[1]; Bertolotti-Ciarlet, Andrea ^[1]; Bhisetti, Govinda R. ^[1]; Lyssikatos, Joseph P. ^[1]; Silvian, Laura F. ^[1]

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1. Department of Drug Discovery, Biogen Inc., 115 Binney Street Cambridge MA 02142
2. Beryllium Discovery Corp., 3 Preston Court Bedford MA 01730

• Research Organization: Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
• Sponsoring Organization: INDUSTRY
• OSTI ID: 1506514
• Journal Information: Protein Science, Vol. 26, Issue 2; ISSN 0961-8368
• Publisher: The Protein Society
• Country of Publication: United States
• Language: ENGLISH