skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Structural determination of the complement inhibitory domain of Borrelia burgdorferi BBK32 provides insight into classical pathway complement evasion by Lyme disease spirochetes

Journal Article · · PLoS Pathogens
; ORCiD logo; ORCiD logo; ; ORCiD logo; ORCiD logo;

Research Organization:
Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
OTHER U.S. GOVERNMENT
OSTI ID:
1506512
Journal Information:
PLoS Pathogens, Vol. 15, Issue 3; ISSN 1553-7374
Publisher:
Public Library of Science
Country of Publication:
United States
Language:
ENGLISH

References (77)

Of ticks, mice and men: understanding the dual-host lifestyle of Lyme disease spirochaetes journal January 2012
Inactivation of the fibronectin-binding adhesin gene bbk32 significantly attenuates the infectivity potential of Borrelia burgdorferi journal January 2006
Primary structure of the A chain of human complement-classical-pathway enzyme C1r. N-terminal sequences and alignment of autolytic fragments and CNBr-cleavage peptides journal January 1985
Binding of the complement inhibitor C4b-binding protein to Lyme disease borreliae journal March 2010
A family of genes located on four separate 32-kilobase circular plasmids in Borrelia burgdorferi B31. journal June 1996
Electrostatics of nanosystems: Application to microtubules and the ribosome journal August 2001
Fibronectin Binding Protein BBK32 of the Lyme Disease Spirochete Promotes Bacterial Attachment to Glycosaminoglycans journal December 2005
Analysis of the OspE Determinants Involved in Binding of Factor H and OspE-Targeting Antibodies Elicited during Borreliaburgdorferi Infection in Mice journal June 2003
Borrelia burgdorferi BBK32 Inhibits the Classical Pathway by Blocking Activation of the C1 Complement Complex journal January 2016
Factor H Family Proteins in Complement Evasion of Microorganisms journal May 2017
Novel Evasion Mechanisms of the Classical Complement Pathway journal September 2016
Complement regulator-acquiring surface proteins of Borrelia burgdorferi: Structure, function and regulation of gene expression journal February 2013
Adhesion, invasion and evasion: the many functions of the surface proteins of Staphylococcus aureus journal December 2013
Borrelia burgdorferi Infection-Associated Surface Proteins ErpP, ErpA, and ErpC Bind Human Plasminogen journal November 2008
Polymorphic factor H-binding activity of CspA protects Lyme borreliae from the host complement in feeding ticks to facilitate tick-to-host transmission journal May 2018
Binding of Human Urokinase Type Plasminogen Activator and Plasminogen to Borrelia Species journal July 1996
Biomechanics of Borrelia burgdorferi Vascular Interactions journal September 2016
A Completely Reimplemented MPI Bioinformatics Toolkit with a New HHpred Server at its Core journal July 2018
Novel mechanisms and functions of complement journal November 2017
CspA from Borrelia burgdorferi Inhibits the Terminal Complement Pathway journal June 2013
BB0744 Affects Tissue Tropism and Spatial Distribution of Borrelia burgdorferi journal July 2015
Bioluminescent imaging of Borrelia burgdorferi in vivo demonstrates that the fibronectin-binding protein BBK32 is required for optimal infectivity: Global imaging of B. burgdorferi in vivo journal August 2011
Phagocytosis Escape by a Staphylococcus aureus Protein That Connects Complement and Coagulation Proteins at the Bacterial Surface journal December 2013
The Role of the Individual Domains in the Structure and Function of the Catalytic Region of a Modular Serine Protease, C1r journal November 2001
PHENIX : building new software for automated crystallographic structure determination journal October 2002
Complement Regulator–Acquiring Surface Protein 1 of Borrelia burgdorferi Binds to Human Bone Morphogenic Protein 2, Several Extracellular Matrix Proteins, and Plasminogen journal August 2010
The BBA33 lipoprotein binds collagen and impacts B orrelia burgdorferi pathogenesis : Collagen binding by journal January 2015
Comprehensive Analysis of the Factor H Binding Capabilities of Borrelia Species Associated with Lyme Disease: Delineation of Two Distinct Classes of Factor H Binding Proteins journal June 2003
Toward the estimation of the absolute quality of individual protein structure models journal December 2010
Structural basis of the C1q/C1s interaction and its central role in assembly of the C1 complex of complement activation journal August 2013
CDC Estimates 300 000 US Cases of Lyme Disease Annually journal September 2013
Allosteric Regulation of Fibronectin/α5β1 Interaction by Fibronectin-Binding MSCRAMMs journal July 2016
Serum-Resistant Strains of Borrelia burgdorferi Evade Complement-Mediated Killing by Expressing a CD59-Like Complement Inhibitory Molecule journal March 2003
Dissolved Oxygen Levels Alter Gene Expression and Antigen Profiles in Borrelia burgdorferi journal February 2004
BBA70 of Borrelia burgdorferi Is a Novel Plasminogen-binding Protein journal July 2013
Borrelia burgdorferi Infection in a Natural Population of Peromyscus Leucopus Mice: A Longitudinal Study in an Area Where Lyme Borreliosis Is Highly Endemic journal April 2004
Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi journal December 1997
Complement: a key system for immune surveillance and homeostasis journal August 2010
Complement evasion by human pathogens journal February 2008
Complement System Part I – Molecular Mechanisms of Activation and Regulation journal June 2015
Plasma fibronectin stabilizes Borrelia burgdorferi –endothelial interactions under vascular shear stress by a catch-bond mechanism journal April 2017
Functional characterization of the lectin pathway of complement in human serum journal January 2003
Borrelia burgdorferi Manipulates Innate and Adaptive Immunity to Establish Persistence in Rodent Reservoir Hosts journal February 2017
Suppression of Long-Lived Humoral Immunity Following Borrelia burgdorferi Infection journal July 2015
Complement as a regulator of adaptive immunity journal August 2017
Binding of complement regulatory proteins to Group A Streptococcus journal December 2008
The crystal structure of the zymogen catalytic domain of complement protease C1r reveals that a disruptive mechanical stress is required to trigger activation of the C1 complex journal February 2002
BBK32, a Fibronectin Binding MSCRAMM from Borrelia burgdorferi, Contains a Disordered Region That Undergoes a Conformational Change on Ligand Binding journal July 2004
Host association of Borrelia burgdorferi sensu lato – the key role of host complement journal February 2002
An optimized system for expression and purification of secreted bacterial proteins journal March 2006
Identification of a 47 kDa fibronectin-binding protein expressed by Borrelia burgdorferi isolate B31 journal December 1998
Mapping the Ligand-Binding Region of Borrelia burgdorferi Fibronectin-Binding Protein BBK32 journal June 2001
Purified proenzyme C1r. Some characteristics of its activation and subsequent proteolytic cleavage journal November 1980
Population genetics, taxonomy, phylogeny and evolution of Borrelia burgdorferi sensu lato journal October 2011
Vascular binding of a pathogen under shear force through mechanistically distinct sequential interactions with host macromolecules: Spirochaete vascular interactions under shear force journal October 2012
Sensitivity of Borrelia genospecies to serum complement from different animals and human: a host–pathogen relationship journal February 2005
Borrelia burgdorferi Alters Its Gene Expression and Antigenic Profile in Response to CO2 Levels journal November 2006
Features and development of Coot journal March 2010
De novo design of protein homo-oligomers with modular hydrogen-bond network-mediated specificity journal May 2016
Fibronectin-Binding Protein of Borrelia hermsii Expressed in the Blood of Mice with Relapsing Fever journal March 2014
Complement System Part II: Role in Immunity journal May 2015
Genetic Transformation and Complementation book October 2017
A Novel Fibronectin Binding Motif in MSCRAMMs Targets F3 Modules journal April 2009
Analysis of the Ability of Spirochete Species Associated with Relapsing Fever, Avian Borreliosis, and Epizootic Bovine Abortion To Bind Factor H and Cleave C3b journal August 2003
Further Characterization of Complement Regulator-Acquiring Surface Proteins of Borrelia burgdorferi journal December 2001
PHENIX: a comprehensive Python-based system for macromolecular structure solution journal January 2010
Analyzing a kinetic titration series using affinity biosensors journal February 2006
Let’s Tie the Knot: Marriage of Complement and Adaptive Immunity in Pathogen Evasion, for Better or Worse journal January 2017
BGA66 and BGA71 facilitate complement resistance of Borrelia bavariensis by inhibiting assembly of the membrane attack complex : Immune evasion of journal October 2015
SWISS-MODEL: homology modelling of protein structures and complexes journal May 2018
Complement Inhibitor Factor H Binding to Lyme Disease Spirochetes Is Mediated by Inducible Expression of Multiple Plasmid-Encoded Outer Surface Protein E Paralogs journal October 2002
Borrelia burgdorferi Protein BBK32 Binds to Soluble Fibronectin via the N-terminal 70-kDa Region, Causing Fibronectin to Undergo Conformational Extension journal June 2014
Complement Evasion by Borrelia burgdorferi: Serum-Resistant Strains Promote C3b Inactivation journal June 2001
Structure of the C1r–C1s interaction of the C1 complex of complement activation journal January 2018
Automated Structure Solution with the PHENIX Suite book January 2008
Glycosaminoglycan binding by B orrelia burgdorferi adhesin BBK32 specifically and uniquely promotes joint colonization : GAG- and fibronectin-binding activities of the journal January 2015
Structures of C1-IgG1 provide insights into how danger pattern recognition activates complement journal February 2018

Similar Records

Related Subjects