Histone methylation: a dynamic mark in health, disease and inheritance
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journal
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April 2012 |
Histone Lysine Methylation Dynamics: Establishment, Regulation, and Biological Impact
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journal
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November 2012 |
Histones: Annotating Chromatin
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journal
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December 2009 |
Cancer epigenomics: DNA methylomes and histone-modification maps
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journal
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March 2007 |
Translating the Histone Code
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journal
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August 2001 |
Critical roles of non-histone protein lysine methylation in human tumorigenesis
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journal
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January 2015 |
Lysine Methylation and Functional Modulation of Androgen Receptor by Set9 Methyltransferase
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journal
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March 2011 |
Chemical mechanisms of histone lysine and arginine modifications
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journal
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January 2009 |
The diverse functions of histone lysine methylation
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journal
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November 2005 |
Chemical Probes of Histone Lysine Methyltransferases
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journal
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November 2014 |
Selective Inhibitors of Protein Methyltransferases
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journal
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December 2014 |
The role of chromatin repressive marks in cognition and disease: A focus on the repressive complex GLP/G9a
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journal
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October 2015 |
Functional Crosstalk Between Lysine Methyltransferases on Histone Substrates: The Case of G9A/GLP and Polycomb Repressive Complex 2
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journal
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June 2015 |
Sound of silence: the properties and functions of repressive Lys methyltransferases
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journal
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July 2015 |
Chromatin Modifications and Their Function
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journal
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February 2007 |
Regulation of chromatin by histone modifications
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journal
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February 2011 |
High-Resolution Profiling of Histone Methylations in the Human Genome
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journal
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May 2007 |
High-Resolution Genome-wide Mapping of the Primary Structure of Chromatin
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journal
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January 2011 |
Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294
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journal
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February 2009 |
Reversal of H3K9me2 by a Small-Molecule Inhibitor for the G9a Histone Methyltransferase
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journal
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February 2007 |
G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis
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journal
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July 2002 |
Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9
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journal
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April 2005 |
Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins
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journal
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March 2009 |
Histone H1 variant-specific lysine methylation by G9a/KMT1C and Glp1/KMT1D
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journal
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January 2010 |
Substrate Specificity and Kinetic Mechanism of Mammalian G9a Histone H3 Methyltransferase
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journal
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December 2004 |
Histone methyltransferase G9a contributes to H3K27 methylation in vivo
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journal
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November 2010 |
Histone H3 Lysine 56 Methylation Regulates DNA Replication through Its Interaction with PCNA
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journal
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April 2012 |
Non-histone protein methylation as a regulator of cellular signalling and function
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journal
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December 2014 |
G9a and Glp methylate lysine 373 in the tumor suppressor p53.
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journal
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June 2010 |
A General Molecular Affinity Strategy for Global Detection and Proteomic Analysis of Lysine Methylation
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journal
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May 2013 |
Negative Regulation of Hypoxic Responses via Induced Reptin Methylation
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journal
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July 2010 |
G9a-mediated methylation of ERα links the PHF20/MOF histone acetyltransferase complex to hormonal gene expression
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journal
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March 2016 |
Protein lysine methyltransferase G9a acts on non-histone targets
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journal
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April 2008 |
Lysine methyltransferase G9a methylates the transcription factor MyoD and regulates skeletal muscle differentiation
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journal
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January 2012 |
Methylation of a Histone Mimic within the Histone Methyltransferase G9a Regulates Protein Complex Assembly
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journal
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August 2007 |
H3K9 methyltransferase G9a and the related molecule GLP
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journal
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April 2011 |
Functional dynamics of H3K9 methylation during meiotic prophase progression
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journal
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June 2007 |
Alterations of DNA methylation and histone modifications contribute to gene silencing in hepatocellular carcinomas
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journal
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November 2007 |
Deregulation of histone lysine methyltransferases contributes to oncogenic transformation of human bronchoepithelial cells
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journal
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January 2008 |
Downregulation of Histone H3 Lysine 9 Methyltransferase G9a Induces Centrosome Disruption and Chromosome Instability in Cancer Cells
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journal
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April 2008 |
Regulation of USP37 Expression by REST-Associated G9a-Dependent Histone Methylation
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journal
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May 2017 |
Essential Role of the Histone Methyltransferase G9a in Cocaine-Induced Plasticity
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journal
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January 2010 |
Control of Cognition and Adaptive Behavior by the GLP/G9a Epigenetic Suppressor Complex
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journal
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December 2009 |
Functional Analysis of Histone Methyltransferase G9a in B and T Lymphocytes
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journal
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June 2008 |
Activating and inhibitory functions for the histone lysine methyltransferase G9a in T helper cell differentiation and function
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journal
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April 2010 |
Lysine methyltransferase G9a is required for de novo DNA methylation and the establishment, but not the maintenance, of proviral silencing
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journal
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March 2011 |
Disruption of the gene Euchromatin Histone Methyl Transferase1 (Eu-HMTase1) is associated with the 9q34 subtelomeric deletion syndrome
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journal
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April 2005 |
Regulation of CD4 T‐cell differentiation and inflammation by repressive histone methylation
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journal
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January 2015 |
Regulation of cell differentiation and function by the euchromatin histone methyltranserfases G9a and GLP
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journal
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February 2016 |
Recognition of H3K9 methylation by GLP is required for efficient establishment of H3K9 methylation, rapid target gene repression, and mouse viability
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journal
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January 2015 |
Unexpected Distinct Roles of the Related Histone H3 Lysine 9 Methyltransferases G9a and G9a-Like Protein in Myoblasts
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journal
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June 2016 |
EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex
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journal
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November 2013 |
Discovery of a 2,4-Diamino-7-aminoalkoxyquinazoline as a Potent and Selective Inhibitor of Histone Lysine Methyltransferase G9a
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journal
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December 2009 |
Protein Lysine Methyltransferase G9a Inhibitors: Design, Synthesis, and Structure Activity Relationships of 2,4-Diamino-7-aminoalkoxy-quinazolines.
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journal
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August 2010 |
Adding a Lysine Mimic in the Design of Potent Inhibitors of Histone Lysine Methyltransferases
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journal
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July 2010 |
Optimization of Cellular Activity of G9a Inhibitors 7-Aminoalkoxy-quinazolines
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journal
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September 2011 |
Discovery of an in Vivo Chemical Probe of the Lysine Methyltransferases G9a and GLP
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journal
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October 2013 |
A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells
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journal
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July 2011 |
A Chemical Tool for In Vitro and In Vivo Precipitation of Lysine Methyltransferase G9a
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journal
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January 2014 |
Discovery and Development of Potent and Selective Inhibitors of Histone Methyltransferase G9a
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journal
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January 2014 |
A Small-Molecule Probe of the Histone Methyltransferase G9a Induces Cellular Senescence in Pancreatic Adenocarcinoma
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journal
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April 2012 |
Analogues of the Natural Product Sinefungin as Inhibitors of EHMT1 and EHMT2
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journal
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February 2014 |
Discovery of novel small molecule inhibitors of lysine methyltransferase G9a and their mechanism in leukemia cell lines
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journal
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October 2016 |
Discovery, design and synthesis of 6 H -anthra[1,9- cd ]isoxazol-6-one scaffold as G9a inhibitor through a combination of shape-based virtual screening and structure-based molecular modification
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journal
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November 2016 |
Inhibition of histone lysine methyltransferases G9a and GLP by ejection of structural Zn(II)
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journal
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April 2018 |
Recently discovered EZH2 and EHMT2 (G9a) inhibitors
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journal
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September 2016 |
Histone lysine methyltransferase structure activity relationships that allow for segregation of G9a inhibition and anti-Plasmodium activity
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journal
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January 2017 |
Discovery of Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase
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journal
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February 2017 |
Structure-activity relationship studies of G9a-like protein (GLP) inhibitors
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journal
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August 2017 |
Inhibitors of Protein Methyltransferases and Demethylases
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journal
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March 2017 |
Cycloalkane analogues of sinefungin as EHMT1/2 inhibitors
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journal
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September 2017 |
Targeting the histone methyltransferase G9a activates imprinted genes and improves survival of a mouse model of Prader–Willi syndrome
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journal
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December 2016 |
The histone methyltransferase G9a as a therapeutic target to override gemcitabine resistance in pancreatic cancer
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journal
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August 2016 |
Methyltransferase G9a promotes cervical cancer angiogenesis and decreases patient survival
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journal
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July 2017 |
Identification of 2,4-diamino-6,7-dimethoxyquinoline derivatives as G9a inhibitors
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journal
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January 2014 |
Classification of scaffold-hopping approaches
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journal
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April 2012 |
Recent Advances in Scaffold Hopping: Miniperspective
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journal
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December 2016 |
Epigenetic Multiple Ligands: Mixed Histone/Protein Methyltransferase, Acetyltransferase, and Class III Deacetylase (Sirtuin) Inhibitors
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journal
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March 2008 |
Synthesis and Biological Validation of Novel Synthetic Histone/Protein Methyltransferase Inhibitors
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journal
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July 2007 |
The emerging role of lysine methyltransferase SETD8 in human diseases
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journal
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September 2016 |
Progress in the Development of Lysine Methyltransferase SETD8 Inhibitors
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journal
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July 2016 |
Identification of PR-SET7 and EZH2 selective inhibitors inducing cell death in human leukemia U937 cells
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journal
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November 2012 |
The Combinatorial Synthesis of Bicyclic Privileged Structures or Privileged Substructures
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journal
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February 2003 |
A continuous-flow synthesis of 1,4-benzodiazepin-5-ones, privileged scaffolds for drug discovery
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journal
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January 2015 |
AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility
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journal
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December 2009 |
A chemiluminescence-based method for identification of histone lysine methyltransferase inhibitors
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journal
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January 2010 |
Interpreting Steep Dose-Response Curves in Early Inhibitor Discovery
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journal
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December 2006 |
The Ecstasy and Agony of Assay Interference Compounds
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journal
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February 2017 |
SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules
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journal
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March 2017 |
FAF-Drugs3: a web server for compound property calculation and chemical library design
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journal
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April 2015 |
New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays
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journal
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April 2010 |
An Aggregation Advisor for Ligand Discovery
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journal
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August 2015 |
Structural Biology of Human H3K9 Methyltransferases
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journal
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January 2010 |
Direct interaction between DNMT1 and G9a coordinates DNA and histone methylation during replication
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journal
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November 2006 |
G9a/GLP complexes independently mediate H3K9 and DNA methylation to silence transcription
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journal
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September 2008 |
5-Aza-2′-deoxycytidine-mediated reductions in G9A histone methyltransferase and histone H3 K9 di-methylation levels are linked to tumor suppressor gene reactivation
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journal
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June 2006 |
UNC0638, a G9a inhibitor, suppresses epithelial‑mesenchymal transition‑mediated cellular migration and invasion in triple negative breast cancer
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journal
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November 2017 |
Discovery of first-in-class reversible dual small molecule inhibitors against G9a and DNMTs in hematological malignancies
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journal
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May 2017 |
Lysine methyltransferase G9a is not required for DNMT3A/3B anchoring to methylated nucleosomes and maintenance of DNA methylation in somatic cells
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journal
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January 2012 |
Targeting DNA Methylation with Small Molecules: What’s Next?: Miniperspective
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journal
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December 2014 |
DNA methylation inhibitors in cancer: Recent and future approaches
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journal
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November 2012 |
Cancer Genetics and Epigenetics: Two Sides of the Same Coin?
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journal
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July 2012 |
Enzymes: A Practical Introduction to Structure, Mechanism, and Data Analysis
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book
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March 2000 |
Determination of permeability and lipophilicity of pyrazolo-pyrimidine tyrosine kinase inhibitors and correlation with biological data
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journal
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September 2009 |
Physicochemical High Throughput Screening: Parallel Artificial Membrane Permeation Assay in the Description of Passive Absorption Processes
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journal
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March 1998 |
A Novel Cell-Permeable, Selective, and Noncompetitive Inhibitor of KAT3 Histone Acetyltransferases from a Combined Molecular Pruning/Classical Isosterism Approach
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journal
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February 2015 |
Applicability of a Blood–Brain Barrier Specific Artificial Membrane Permeability Assay at the Early Stage of Natural Product-Based CNS Drug Discovery
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journal
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March 2013 |
The histone methyltransferase EZH2 as a druggable target in SHH medulloblastoma cancer stem cells
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journal
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August 2017 |
Virtual screening with AutoDock: theory and practice
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journal
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April 2010 |
Structure-Based Virtual Screening and Biological Evaluation of Mycobacterium tuberculosis Adenosine 5′-Phosphosulfate Reductase Inhibitors
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journal
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October 2008 |
Identification of Structural Features of 2-Alkylidene-1,3-Dicarbonyl Derivatives that Induce Inhibition and/or Activation of Histone Acetyltransferases KAT3B/p300 and KAT2B/PCAF
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journal
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October 2014 |
High-Throughput Permeability pH Profile and High-Throughput Alkane/Water log P with Artificial Membranes
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journal
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March 2001 |
High Throughput Prediction of Oral Absorption: Improvement of the Composition of the Lipid Solution Used in Parallel Artificial Membrane Permeation Assay
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journal
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June 2001 |
Multiparametric scaling of diffraction intensities
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journal
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April 2003 |
Features and development of Coot
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journal
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March 2010 |
Coot model-building tools for molecular graphics
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journal
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November 2004 |
PHENIX : building new software for automated crystallographic structure determination
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journal
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October 2002 |
PHENIX: a comprehensive Python-based system for macromolecular structure solution
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journal
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January 2010 |