Structural basis of neurosteroid anesthetic action on GABAA receptors

Chen, Qiang; Wells, Marta M.; Arjunan, Palaniappa; Tillman, Tommy S.; Cohen, Aina E.; Xu, Yan; Tang, Pei

doi:10.1038/s41467-018-06361-4

Title: Structural basis of neurosteroid anesthetic action on GABAA receptors

Journal Article · Fri Sep 28 00:00:00 EDT 2018 · Nature Communications

DOI:https://doi.org/10.1038/s41467-018-06361-4· OSTI ID:1506500

; Wells, Marta M.; Arjunan, Palaniappa; Tillman, Tommy S.; Cohen, Aina E.;

; Tang, Pei

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Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES); USDOE Office of Science (SC), Biological and Environmental Research (BER); National Institutes of Health (NIH)

OSTI ID:: 1506500

Journal Information:: Nature Communications, Vol. 9, Issue 1; ISSN 2041-1723

Publisher:: Nature Publishing Group

Country of Publication:: United States

Language:: ENGLISH

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Identification of naturally originated molecules as γ-aminobutyric acid receptor antagonist Sharma, Jatin; Bhardwaj, Vijay Kumar; Das, Pralay Journal of Biomolecular Structure and Dynamics https://doi.org/10.1080/07391102.2020.1720818	journal	February 2020
Binding site location on GABA _A receptors determines whether mixtures of intravenous general anaesthetics interact synergistically or additively in vivo Kent, Daniel E.; Savechenkov, Pavel Y.; Bruzik, Karol S. British Journal of Pharmacology, Vol. 176, Issue 24 https://doi.org/10.1111/bph.14843	journal	December 2019
Brexanolone, a neurosteroid antidepressant, vindicates the GABAergic deficit hypothesis of depression and may foster resilience Lüscher, Bernhard; Möhler, Hanns F1000Research, Vol. 8 https://doi.org/10.12688/f1000research.18758.1	journal	January 2019
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