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Title: Retractile lysyl-tRNA synthetase-AIMP2 assembly in the human multi-aminoacyl-tRNA synthetase complex

Authors:
ORCiD logo; ; ; ; ORCiD logo
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Org.:
FOREIGN
OSTI Identifier:
1504973
Resource Type:
Journal Article
Journal Name:
Journal of Biological Chemistry
Additional Journal Information:
Journal Volume: 294; Journal Issue: 13; Journal ID: ISSN 0021-9258
Publisher:
American Society for Biochemistry and Molecular Biology
Country of Publication:
United States
Language:
ENGLISH

Citation Formats

Hei, Zhoufei, Wu, Siqi, Liu, Zaizhou, Wang, Jing, and Fang, Pengfei. Retractile lysyl-tRNA synthetase-AIMP2 assembly in the human multi-aminoacyl-tRNA synthetase complex. United States: N. p., 2019. Web. doi:10.1074/jbc.RA118.006356.
Hei, Zhoufei, Wu, Siqi, Liu, Zaizhou, Wang, Jing, & Fang, Pengfei. Retractile lysyl-tRNA synthetase-AIMP2 assembly in the human multi-aminoacyl-tRNA synthetase complex. United States. doi:10.1074/jbc.RA118.006356.
Hei, Zhoufei, Wu, Siqi, Liu, Zaizhou, Wang, Jing, and Fang, Pengfei. Thu . "Retractile lysyl-tRNA synthetase-AIMP2 assembly in the human multi-aminoacyl-tRNA synthetase complex". United States. doi:10.1074/jbc.RA118.006356.
@article{osti_1504973,
title = {Retractile lysyl-tRNA synthetase-AIMP2 assembly in the human multi-aminoacyl-tRNA synthetase complex},
author = {Hei, Zhoufei and Wu, Siqi and Liu, Zaizhou and Wang, Jing and Fang, Pengfei},
abstractNote = {},
doi = {10.1074/jbc.RA118.006356},
journal = {Journal of Biological Chemistry},
issn = {0021-9258},
number = 13,
volume = 294,
place = {United States},
year = {2019},
month = {2}
}

Works referenced in this record:

Two-Site Phosphorylation of EPRS Coordinates Multimodal Regulation of Noncanonical Translational Control Activity
journal, July 2009


Structural interpretation of low-temperature heme-ligand recombination rates in myoglobin
journal, April 1985


Noncanonical Function of Glutamyl-Prolyl-tRNA Synthetase
journal, October 2004


Endothelial-Monocyte Activating Polypeptide Ii, a Novel Antitumor Cytokine That Suppresses Primary and Metastatic Tumor Growth and Induces Apoptosis in Growing Endothelial Cells
journal, August 1999

  • Schwarz, Margaret A.; Kandel, Jessica; Brett, Jerald
  • The Journal of Experimental Medicine, Vol. 190, Issue 3
  • DOI: 10.1084/jem.190.3.341

Structure of the ArgRS–GlnRS–AIMP1 complex and its implications for mammalian translation
journal, October 2014

  • Fu, Yaoyao; Kim, Youngran; Jin, Kyeong Sik
  • Proceedings of the National Academy of Sciences, Vol. 111, Issue 42
  • DOI: 10.1073/pnas.1408836111

Shiga Toxins Trigger the Secretion of Lysyl-tRNA Synthetase to Enhance Proinflammatory Responses
journal, February 2016

  • Lee, Moo-Seung; Kwon, Haenaem; Nguyen, Loi T.
  • Journal of Microbiology and Biotechnology, Vol. 26, Issue 2
  • DOI: 10.4014/jmb.1511.11056

Structural context for mobilization of a human tRNA synthetase from its cytoplasmic complex
journal, May 2011

  • Fang, P.; Zhang, H. -M.; Shapiro, R.
  • Proceedings of the National Academy of Sciences, Vol. 108, Issue 20
  • DOI: 10.1073/pnas.1100224108

Essential nontranslational functions of tRNA synthetases
journal, February 2013


Formation of the tRNA Lys packaging complex in HIV-1
journal, November 2009


From The Cover: Human lysyl-tRNA synthetase is secreted to trigger proinflammatory response
journal, April 2005

  • Park, S. G.; Kim, H. J.; Min, Y. H.
  • Proceedings of the National Academy of Sciences, Vol. 102, Issue 18
  • DOI: 10.1073/pnas.0500226102

Dose-dependent Biphasic Activity of tRNA Synthetase-associating Factor, p43, in Angiogenesis
journal, September 2002

  • Park, Sang Gyu; Kang, Young-Sun; Ahn, Young Ha
  • Journal of Biological Chemistry, Vol. 277, Issue 47
  • DOI: 10.1074/jbc.M207934200

Non-canonical roles of lysyl-tRNA synthetase in health and disease
journal, December 2013


Heterotrimeric GAIT Complex Drives Transcript-Selective Translation Inhibition in Murine Macrophages
journal, October 2012

  • Arif, A.; Chatterjee, P.; Moodt, R. A.
  • Molecular and Cellular Biology, Vol. 32, Issue 24
  • DOI: 10.1128/MCB.01168-12

Dual role of methionyl-tRNA synthetase in the regulation of translation and tumor suppressor activity of aminoacyl-tRNA synthetase-interacting multifunctional protein-3
journal, November 2011

  • Kwon, N. H.; Kang, T.; Lee, J. Y.
  • Proceedings of the National Academy of Sciences, Vol. 108, Issue 49
  • DOI: 10.1073/pnas.1103922108

HIV-1 Exploits a Dynamic Multi-aminoacyl-tRNA Synthetase Complex To Enhance Viral Replication
journal, August 2017

  • Duchon, Alice A.; St. Gelais, Corine; Titkemeier, Nathan
  • Journal of Virology, Vol. 91, Issue 21
  • DOI: 10.1128/JVI.01240-17

Features and development of Coot
journal, March 2010

  • Emsley, P.; Lohkamp, B.; Scott, W. G.
  • Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 4
  • DOI: 10.1107/S0907444910007493

Aminoacyl-tRNA Synthetase Complexes in Evolution
journal, March 2015

  • Havrylenko, Svitlana; Mirande, Marc
  • International Journal of Molecular Sciences, Vol. 16, Issue 12
  • DOI: 10.3390/ijms16036571

The p43 Component of the Mammalian Multi-synthetase Complex Is Likely To Be the Precursor of the Endothelial Monocyte-activating Polypeptide II Cytokine
journal, December 1997

  • Quevillon, Sophie; Agou, Fabrice; Robinson, Jean-Charles
  • Journal of Biological Chemistry, Vol. 272, Issue 51
  • DOI: 10.1074/jbc.272.51.32573

Anticodon-like binding of the HIV-1 tRNA-like element to human lysyl-tRNA synthetase
journal, October 2016


The EMAPII Cytokine Is Released from the Mammalian Multisynthetase Complex after Cleavage of Its p43/proEMAPII Component
journal, April 2001

  • Shalak, Vyacheslav; Kaminska, Monika; Mitnacht-Kraus, Rita
  • Journal of Biological Chemistry, Vol. 276, Issue 26
  • DOI: 10.1074/jbc.M100489200

Structural Switch of Lysyl-tRNA Synthetase between Translation and Transcription
journal, January 2013


Aminoacyl-tRNA Synthesis
journal, June 2000


Macromolecular complexes as depots for releasable regulatory proteins
journal, April 2007


PHENIX: a comprehensive Python-based system for macromolecular structure solution
journal, January 2010

  • Adams, Paul D.; Afonine, Pavel V.; Bunkóczi, Gábor
  • Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 2, p. 213-221
  • DOI: 10.1107/S0907444909052925

Assembly of Multi-tRNA Synthetase Complex via Heterotetrameric Glutathione Transferase-homology Domains
journal, October 2015

  • Cho, Ha Yeon; Maeng, Seo Jin; Cho, Hyo Je
  • Journal of Biological Chemistry, Vol. 290, Issue 49
  • DOI: 10.1074/jbc.M115.690867

Infection-specific phosphorylation of glutamyl-prolyl tRNA synthetase induces antiviral immunity
journal, September 2016

  • Lee, Eun-Young; Lee, Hyun-Cheol; Kim, Hyun-Kwan
  • Nature Immunology, Vol. 17, Issue 11
  • DOI: 10.1038/ni.3542

Interaction of two translational components, lysyl-tRNA synthetase and p40/37LRP, in plasma membrane promotes laminin-dependent cell migration
journal, October 2012

  • Kim, Dae Gyu; Choi, Jin Woo; Lee, Jin Young
  • The FASEB Journal, Vol. 26, Issue 10
  • DOI: 10.1096/fj.12-207639

Chemical inhibition of prometastatic lysyl-tRNA synthetase–laminin receptor interaction
journal, November 2013

  • Kim, Dae Gyu; Lee, Jin Young; Kwon, Nam Hoon
  • Nature Chemical Biology, Vol. 10, Issue 1
  • DOI: 10.1038/nchembio.1381

LysRS Serves as a Key Signaling Molecule in the Immune Response by Regulating Gene Expression
journal, June 2009


NMRPipe: A multidimensional spectral processing system based on UNIX pipes
journal, November 1995

  • Delaglio, Frank; Grzesiek, Stephan; Vuister, GeertenW.
  • Journal of Biomolecular NMR, Vol. 6, Issue 3
  • DOI: 10.1007/BF00197809

Molecular replacement with MOLREP
journal, December 2009

  • Vagin, Alexei; Teplyakov, Alexei
  • Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 1
  • DOI: 10.1107/S0907444909042589

Characterization of p43(ARF), a Derivative of the p43 Component of Multiaminoacyl-tRNA Synthetase Complex Released during Apoptosis
journal, February 2007

  • Shalak, Vyacheslav; Guigou, Ludovic; Kaminska, Monika
  • Journal of Biological Chemistry, Vol. 282, Issue 15
  • DOI: 10.1074/jbc.M611737200

Small-angle X-ray Solution Scattering Study of the Multi-aminoacyl-tRNA Synthetase Complex Reveals an Elongated and Multi-armed particle
journal, July 2013

  • Dias, José; Renault, Louis; Pérez, Javier
  • Journal of Biological Chemistry, Vol. 288, Issue 33
  • DOI: 10.1074/jbc.M113.489922

Endothelial monocyte-activating polypeptide-II (EMAP-II): a novel inducer of lymphocyte apoptosis
journal, February 2004

  • Murray, J. C.; Heng, Y. M.; Symonds, P.
  • Journal of Leukocyte Biology, Vol. 75, Issue 5
  • DOI: 10.1189/jlb.1003487

Oncogenic Mutation of AIMP2/p38 Inhibits Its Tumor-Suppressive Interaction with Smurf2
journal, April 2016


Cognition, Mechanism, and Evolutionary Relationships in Aminoacyl-tRNA Synthetases
journal, June 1993


Novel mutations in KARS cause hypertrophic cardiomyopathy and combined mitochondrial respiratory chain defect : Novel mutations in
journal, March 2017

  • Verrigni, D.; Diodato, D.; Di Nottia, M.
  • Clinical Genetics, Vol. 91, Issue 6
  • DOI: 10.1111/cge.12931