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Title: SaVanT: a web-based tool for the sample-level visualization of molecular signatures in gene expression profiles

Journal Article · · BMC Genomics
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Molecular signatures are collections of genes characteristic of a particular cell type, tissue, disease, or perturbation. Signatures can also be used to interpret expression profiles generated from heterogeneous samples. Large collections of gene signatures have been previously developed and catalogued in the MSigDB database. In addition, several consortia and large-scale projects have systematically profiled broad collections of purified primary cells, molecular perturbations of cell types, and tissues from specific diseases, and the specificity and breadth of these datasets can be leveraged to create additional molecular signatures. However, to date there are few tools that allow the visualization of individual signatures across large numbers of expression profiles. Signature visualization of individual samples allows, for example, the identification of patient subcategories a priori on the basis of well-defined molecular signatures.

Research Organization:
Univ. of California, Los Angeles, CA (United States)
Sponsoring Organization:
USDOE Office of Science (SC)
Grant/Contract Number:
DE–FC02–02ER63421; FC02-02ER63421
OSTI ID:
1618561
Alternate ID(s):
OSTI ID: 1504905
Journal Information:
BMC Genomics, Journal Name: BMC Genomics Vol. 18 Journal Issue: 1; ISSN 1471-2164
Publisher:
Springer Science + Business MediaCopyright Statement
Country of Publication:
United Kingdom
Language:
English
Citation Metrics:
Cited by: 21 works
Citation information provided by
Web of Science

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Cited By (2)

Identification of a systemic interferon-γ inducible antimicrobial gene signature in leprosy patients undergoing reversal reaction journal October 2019
From Big Data to Precision Medicine journal March 2019

Linked Research (5)

Figures / Tables (5)

Table 1(p. 3)table Table 1
Fig. 1(p. 4)figure Fig. 1
Fig. 2(p. 4)figure Fig. 2
Fig. 3(p. 6)figure Fig. 3
Table 2(p. 7)table Table 2

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59 BASIC BIOLOGICAL SCIENCES
Molecular signatures
Transcriptomic analysis
Tissue-specific expression
Heterogeneous samples
Visualization tools