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Title: 24-hour human urine and serum profiles of bisphenol A: Evidence against sublingual absorption following ingestion in soup

Abstract

Extensive first-pass metabolism of ingested bisphenol A (BPA) in the gastro-intestinal tract and liver restricts blood concentrations of bioactive BPA to <1% of total BPA in humans and non-human primates. Absorption of ingested BPA through non-metabolizing tissues of the oral cavity, recently demonstrated in dogs, could lead to the higher serum BPA concentrations reported in some human biomonitoring studies. We hypothesized that the extensive interaction with the oral mucosa by a liquid matrix, like soup, relative to solid food or capsules, might enhance absorption through non-metabolizing oral cavity tissues in humans, producing higher bioavailability and higher serum BPA concentrations. Concurrent serum and urine concentrations of d6-BPA, and its glucuronide and sulfate conjugates, were measured over a 24 hour period in 10 adult male volunteers following ingestion of 30 µg d6-BPA/kg body weight in soup. Absorption of d6-BPA was rapid (t1/2 = 0.45 h) and elimination of the administered dose was complete 24 hours post-ingestion, evidence against any tissue depot for BPA. The maximum serum d6-BPA concentration was 0.43 nM at 1.6 h after administration and represented <0.3% of total d6-BPA. Pharmacokinetic parameters, pharmacokinetic model simulations, and the significantly faster appearance half-life of d6-BPA-glucuronide compared to d6-BPA (0.29 h vs 0.45more » h) were evidence against meaningful absorption of BPA in humans through any non-metabolizing tissue (<1%). This study confirms that typical exposure to BPA in food produces picomolar to subpicomolar serum BPA concentrations in humans, not nM“ng/ml” concentrations reported in some biomonitoring studies.« less

Authors:
; ; ; ; ; ;
Publication Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1504411
Report Number(s):
PNNL-ACT-SA-10045
Journal ID: ISSN 0041-008X
DOE Contract Number:  
AC05-76RL01830
Resource Type:
Journal Article
Journal Name:
Toxicology and Applied Pharmacology
Additional Journal Information:
Journal Volume: 288; Journal Issue: 2; Journal ID: ISSN 0041-008X
Publisher:
Elsevier
Country of Publication:
United States
Language:
English
Subject:
human urine, serum profiles, bisphenol A, sublingual absorption

Citation Formats

Teeguarden, Justin G., Twaddle, Nathan C., Churchwell, Mona I., Yang, Xiaoxia, Fisher, Jeffrey W., Seryak, Liesel M., and Doerge, Daniel R. 24-hour human urine and serum profiles of bisphenol A: Evidence against sublingual absorption following ingestion in soup. United States: N. p., 2015. Web. doi:10.1016/j.taap.2015.01.009.
Teeguarden, Justin G., Twaddle, Nathan C., Churchwell, Mona I., Yang, Xiaoxia, Fisher, Jeffrey W., Seryak, Liesel M., & Doerge, Daniel R. 24-hour human urine and serum profiles of bisphenol A: Evidence against sublingual absorption following ingestion in soup. United States. doi:10.1016/j.taap.2015.01.009.
Teeguarden, Justin G., Twaddle, Nathan C., Churchwell, Mona I., Yang, Xiaoxia, Fisher, Jeffrey W., Seryak, Liesel M., and Doerge, Daniel R. Thu . "24-hour human urine and serum profiles of bisphenol A: Evidence against sublingual absorption following ingestion in soup". United States. doi:10.1016/j.taap.2015.01.009.
@article{osti_1504411,
title = {24-hour human urine and serum profiles of bisphenol A: Evidence against sublingual absorption following ingestion in soup},
author = {Teeguarden, Justin G. and Twaddle, Nathan C. and Churchwell, Mona I. and Yang, Xiaoxia and Fisher, Jeffrey W. and Seryak, Liesel M. and Doerge, Daniel R.},
abstractNote = {Extensive first-pass metabolism of ingested bisphenol A (BPA) in the gastro-intestinal tract and liver restricts blood concentrations of bioactive BPA to <1% of total BPA in humans and non-human primates. Absorption of ingested BPA through non-metabolizing tissues of the oral cavity, recently demonstrated in dogs, could lead to the higher serum BPA concentrations reported in some human biomonitoring studies. We hypothesized that the extensive interaction with the oral mucosa by a liquid matrix, like soup, relative to solid food or capsules, might enhance absorption through non-metabolizing oral cavity tissues in humans, producing higher bioavailability and higher serum BPA concentrations. Concurrent serum and urine concentrations of d6-BPA, and its glucuronide and sulfate conjugates, were measured over a 24 hour period in 10 adult male volunteers following ingestion of 30 µg d6-BPA/kg body weight in soup. Absorption of d6-BPA was rapid (t1/2 = 0.45 h) and elimination of the administered dose was complete 24 hours post-ingestion, evidence against any tissue depot for BPA. The maximum serum d6-BPA concentration was 0.43 nM at 1.6 h after administration and represented <0.3% of total d6-BPA. Pharmacokinetic parameters, pharmacokinetic model simulations, and the significantly faster appearance half-life of d6-BPA-glucuronide compared to d6-BPA (0.29 h vs 0.45 h) were evidence against meaningful absorption of BPA in humans through any non-metabolizing tissue (<1%). This study confirms that typical exposure to BPA in food produces picomolar to subpicomolar serum BPA concentrations in humans, not nM“ng/ml” concentrations reported in some biomonitoring studies.},
doi = {10.1016/j.taap.2015.01.009},
journal = {Toxicology and Applied Pharmacology},
issn = {0041-008X},
number = 2,
volume = 288,
place = {United States},
year = {2015},
month = {10}
}