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Title: Effects of copper occupancy on the conformational landscape of peptidylglycine α-hydroxylating monooxygenase

Journal Article · · Communications Biology

Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
NSFNIH
OSTI ID:
1503697
Journal Information:
Communications Biology, Vol. 1, Issue 1; ISSN 2399-3642
Publisher:
Springer Nature
Country of Publication:
United States
Language:
ENGLISH

References (58)

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A "Neural" Enzyme in Nonbilaterian Animals and Algae: Preneural Origins for Peptidylglycine  -Amidating Monooxygenase journal April 2012
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Coordination of peroxide to the CuM center of peptidylglycine α-hydroxylating monooxygenase (PHM): structural and computational study journal December 2012
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The Catalytic Copper of Peptidylglycine α-Hydroxylating Monooxygenase also Plays a Critical Structural Role journal November 2005
Differential Reactivity between Two Copper Sites in Peptidylglycine α-Hydroxylating Monooxygenase journal November 2010
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The Catalytic Role of the Copper Ligand H172 of Peptidylglycine α-Hydroxylating Monooxygenase:  A Kinetic Study of the H172A Mutant journal December 2006
Stopped-Flow Studies of the Reduction of the Copper Centers Suggest a Bifurcated Electron Transfer Pathway in Peptidylglycine Monooxygenase journal March 2016
Peptidylglycine-α-Hydroxylating Monooxygenase Generates Two Hydroxylated Products from Its Mechanism-Based Suicide Substrate, 4-Phenyl-3-butenoic Acid journal July 2000
Substituted hippurates and hippurate analogs as substrates and inhibitors of peptidylglycine α-hydroxylating monooxygenase (PHM) journal December 2008
Probing the Peptidylglycine α-Hydroxylating Monooxygenase Active Site with Novel 4-Phenyl-3-butenoic Acid Based Inhibitors journal August 2010
Hydroxylase Activity of Met471Cys Tyramine β-Monooxygenase journal September 2008
Structural Investigations on the Coordination Environment of the Active-Site Copper Centers of Recombinant Bifunctional Peptidylglycine α-Amidating Enzyme journal January 1996
Oxygen Activation by the Noncoupled Binuclear Copper Site in Peptidylglycine α-Hydroxylating Monooxygenase. Spectroscopic Definition of the Resting Sites and the Putative Cu II M −OOH Intermediate journal May 2004
Isocyanide binding to the copper(I) centers of the catalytic core of peptidylglycine monooxygenase (PHMcc) journal May 2001
X-ray Absorption Edge Spectroscopy and Computational Studies on LCuO 2 Species:  Superoxide−Cu II versus Peroxide−Cu III Bonding journal June 2006
Lumenal Loop M672-P707 of the Menkes Protein (ATP7A) Transfers Copper to Peptidylglycine Monooxygenase journal June 2012
HHM Motif at the CuH-Site of Peptidylglycine Monooxygenase is a pH-Dependent Conformational Switch journal April 2013
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Oxygen Activation by the Noncoupled Binuclear Copper Site in Peptidylglycine α-Hydroxylating Monooxygenase. Reaction Mechanism and Role of the Noncoupled Nature of the Active Site journal April 2004
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Bifunctional Peptidylglycine α-Amidating Enzyme Requires 2 Copper Atoms for Maximum Activity journal May 1994
Peptidylglycine α-Hydroxylating Monooxygenase:  Active Site Residues, Disulfide Linkages, and a Two-Domain Model of the Catalytic Core journal September 1997
Identification of the Five Essential Histidine Residues for Peptidylglycine Monooxygenase journal January 1996
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Further Characterization of Peptidylglycine α-Amidating Monooxygenase from Bovine Neurointermediate Pituitary* journal April 1987
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Plausible molecular mechanism for activation by fumarate and electron transfer of the dopamine β-mono-oxygenase reaction journal October 2002
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Hydrogen Tunneling in Peptidylglycine α-Hydroxylating Monooxygenase journal July 2002
Kinetic Mechanism and Intrinsic Isotope Effects for the Peptidylglycine α-Amidating Enzyme Reaction journal June 1998
Interdomain Long-Range Electron Transfer Becomes Rate-Limiting in the Y216A Variant of Tyramine β-Monooxygenase journal February 2013
Supplying Copper to the Cuproenzyme Peptidylglycine α-Amidating Monooxygenase journal January 2003
A Copper–Methionine Interaction Controls the pH-Dependent Activation of Peptidylglycine Monooxygenase journal December 2011
The Catalytic Role of the Copper Ligand H172 of Peptidylglycine α-Hydroxylating Monooxygenase (PHM):  A Spectroscopic Study of the H172A Mutant journal November 2002
The Hydrogen Peroxide Reactivity of Peptidylglycine Monooxygenase Supports a Cu(II)-Superoxo Catalytic Intermediate journal January 2006
Substrate-Induced Carbon Monoxide Reactivity Suggests Multiple Enzyme Conformations at the Catalytic Copper M-Center of Peptidylglycine Monooxygenase journal November 2016
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Major changes in copper coordination accompany reduction of peptidylglycine monooxygenase: implications for electron transfer and the catalytic mechanism journal June 2000
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Large scale production of the copper enzyme peptidylglycine monooxygenase using an automated bioreactor journal January 2007
Features and development of Coot journal March 2010
A graphical user interface to the CCP 4 program suite journal June 2003
Ongoing developments in CCP 4 for high-throughput structure determination journal October 2002
MolProbity : all-atom structure validation for macromolecular crystallography journal December 2009

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