Targeted brain proteomics uncover multiple pathways to Alzheimer's dementia: Targeted Proteomics in Alzheimer's Dementia

Yu, Lei; Petyuk, Vladislav A.; Gaiteri, Chris; Mostafavi, Sara; Young-Pearse, Tracy; Shah, Raj C.; Buchman, Aron S.; Schneider, Julie A.; Piehowski, Paul D.; Sontag, Ryan L.; Fillmore, Thomas L.; Shi, Tujin; Smith, Richard D.; De Jager, Philip L.; Bennett, David A.

doi:10.1002/ana.25266

Targeted brain proteomics uncover multiple pathways to Alzheimer's dementia: Targeted Proteomics in Alzheimer's Dementia

Journal Article · 01 July 2018 · Annals of Neurology

DOI:https://doi.org/10.1002/ana.25266· OSTI ID:1503619

Yu, Lei ^[1]; Petyuk, Vladislav A. ^[2]; Gaiteri, Chris ^[1]; Mostafavi, Sara ^[3]; Young-Pearse, Tracy ^[4]; Shah, Raj C. ^[5]; Buchman, Aron S. ^[1]; Schneider, Julie A. ^[6]; Piehowski, Paul D. ^[2]; Sontag, Ryan L. ^[2]; Fillmore, Thomas L. ^[2]; Shi, Tujin ^[2]; Smith, Richard D. ^[2]; De Jager, Philip L. ^[7]; Bennett, David A. ^[1]

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago IL; Department of Neurological Sciences, Rush University Medical Center, Chicago IL
Pacific Northwest National Laboratory, Richland WA
University of British Columbia, Vancouver British Columbia Canada
Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Departments of Neurology and Psychiatry, Brigham and Women's Hospital, Boston MA; Harvard Medical School, Boston MA
Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago IL; Department of Family Medicine, Rush University Medical Center, Chicago IL
Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago IL; Department of Neurological Sciences, Rush University Medical Center, Chicago IL; Department of Pathology, Rush University Medical Center, Chicago IL
Center for Translational and Computational Neuroimmunology, Columbia University Medical Center, New York NY; Cell Circuits Program, Broad Institute, Cambridge MA

Previous gene expression analysis identified a network of coexpressed genes that is associated with bamyloid neuropathology and cognitive decline in older adults. The current work targeted influential genes in this network with quantitative proteomics to identify potential novel therapeutic targets.

Research Organization:: Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC05-76RL01830

OSTI ID:: 1503619

Report Number(s):: PNNL-SA-136156

Journal Information:: Annals of Neurology, Vol. 84, Issue 1; ISSN 0364-5134

Country of Publication:: United States

Language:: English

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