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Title: Moonshot Objectives: Catalyze New Scientific Breakthroughs—Proteogenomics

Abstract

Breaking down the silos between disciplines to accelerate the pace of cancer research is a key paradigm for the Cancer Moonshot. Molecular analyses of cancer biology have tended to segregate between a focus on nucleic acids – DNA, RNA and their modifications – and a focus on proteins and protein function. Proteogenomics represents a fusion of those two fields, leveraging the strengths of each to provide a more integrated vision of the flow of information from DNA to RNA to protein and eventually function. Proteogenomic studies have been incorporated into multiple activities associated with the cancer moonshot, demonstrating substantial added value. Innovative study designs integrating genomic, transcriptomic and proteomic data, particularly those that use clinically relevant samples and engage clinical trials, are poised to provide new insights regarding cancer risk, progression, and response to therapy,

Authors:
; ;
Publication Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1503588
Report Number(s):
PNNL-ACT-SA-10292
Journal ID: ISSN 1528-9117
DOE Contract Number:  
AC05-76RL01830
Resource Type:
Journal Article
Journal Name:
The Cancer Journal
Additional Journal Information:
Journal Volume: 24; Journal Issue: 3; Journal ID: ISSN 1528-9117
Country of Publication:
United States
Language:
English
Subject:
proteogenomics, proteomics, cancer moonshot, mass spectrometry

Citation Formats

Rodland, Karin D., Piehowski, Paul, and Smith, Richard D. Moonshot Objectives: Catalyze New Scientific Breakthroughs—Proteogenomics. United States: N. p., 2018. Web. doi:10.1097/PPO.0000000000000315.
Rodland, Karin D., Piehowski, Paul, & Smith, Richard D. Moonshot Objectives: Catalyze New Scientific Breakthroughs—Proteogenomics. United States. doi:10.1097/PPO.0000000000000315.
Rodland, Karin D., Piehowski, Paul, and Smith, Richard D. Mon . "Moonshot Objectives: Catalyze New Scientific Breakthroughs—Proteogenomics". United States. doi:10.1097/PPO.0000000000000315.
@article{osti_1503588,
title = {Moonshot Objectives: Catalyze New Scientific Breakthroughs—Proteogenomics},
author = {Rodland, Karin D. and Piehowski, Paul and Smith, Richard D.},
abstractNote = {Breaking down the silos between disciplines to accelerate the pace of cancer research is a key paradigm for the Cancer Moonshot. Molecular analyses of cancer biology have tended to segregate between a focus on nucleic acids – DNA, RNA and their modifications – and a focus on proteins and protein function. Proteogenomics represents a fusion of those two fields, leveraging the strengths of each to provide a more integrated vision of the flow of information from DNA to RNA to protein and eventually function. Proteogenomic studies have been incorporated into multiple activities associated with the cancer moonshot, demonstrating substantial added value. Innovative study designs integrating genomic, transcriptomic and proteomic data, particularly those that use clinically relevant samples and engage clinical trials, are poised to provide new insights regarding cancer risk, progression, and response to therapy,},
doi = {10.1097/PPO.0000000000000315},
journal = {The Cancer Journal},
issn = {1528-9117},
number = 3,
volume = 24,
place = {United States},
year = {2018},
month = {1}
}