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Title: Mass spectrometry-based proteomics for system-level characterization of biological responses to engineered nanomaterials

Abstract

The widespread applications of engineered nanomaterials or nanotechnology make the characterization of biological responses to nanomaterials as an important area of research. The applications of omics-based approaches such as mass spectrometry-based proteomics have revealed new insights into the cellular responses upon exposure to nanomaterials, including how nanomaterials interact and alter cellular pathways. For instance, a redox-dependent response is often associated with exposure of nanomaterials, which leads to the generation of reactive oxygen species. In this review, we discuss the general quantitative proteomics approaches, with an emphasis on redox proteomics and their applications for characterizing the biological responses to nanomaterials.

Authors:
; ; ; ORCiD logo
Publication Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1503587
Report Number(s):
PNNL-SA-133275
Journal ID: ISSN 1618-2642
DOE Contract Number:  
AC05-76RL01830
Resource Type:
Journal Article
Journal Name:
Analytical and Bioanalytical Chemistry
Additional Journal Information:
Journal Volume: 410; Journal Issue: 24; Journal ID: ISSN 1618-2642
Publisher:
Springer
Country of Publication:
United States
Language:
English

Citation Formats

Zhang, Tong, Gaffrey, Matthew J., Thrall, Brian D., and Qian, Wei-Jun. Mass spectrometry-based proteomics for system-level characterization of biological responses to engineered nanomaterials. United States: N. p., 2018. Web. doi:10.1007/s00216-018-1168-6.
Zhang, Tong, Gaffrey, Matthew J., Thrall, Brian D., & Qian, Wei-Jun. Mass spectrometry-based proteomics for system-level characterization of biological responses to engineered nanomaterials. United States. doi:10.1007/s00216-018-1168-6.
Zhang, Tong, Gaffrey, Matthew J., Thrall, Brian D., and Qian, Wei-Jun. Fri . "Mass spectrometry-based proteomics for system-level characterization of biological responses to engineered nanomaterials". United States. doi:10.1007/s00216-018-1168-6.
@article{osti_1503587,
title = {Mass spectrometry-based proteomics for system-level characterization of biological responses to engineered nanomaterials},
author = {Zhang, Tong and Gaffrey, Matthew J. and Thrall, Brian D. and Qian, Wei-Jun},
abstractNote = {The widespread applications of engineered nanomaterials or nanotechnology make the characterization of biological responses to nanomaterials as an important area of research. The applications of omics-based approaches such as mass spectrometry-based proteomics have revealed new insights into the cellular responses upon exposure to nanomaterials, including how nanomaterials interact and alter cellular pathways. For instance, a redox-dependent response is often associated with exposure of nanomaterials, which leads to the generation of reactive oxygen species. In this review, we discuss the general quantitative proteomics approaches, with an emphasis on redox proteomics and their applications for characterizing the biological responses to nanomaterials.},
doi = {10.1007/s00216-018-1168-6},
journal = {Analytical and Bioanalytical Chemistry},
issn = {1618-2642},
number = 24,
volume = 410,
place = {United States},
year = {2018},
month = {6}
}

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