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Title: Crystal structure of the mouse innate immunity factor bacterial permeability-increasing family member A1

Abstract

Bacterial permeability-increasing family member A1 (BPIFA1) is an innate immunity factor and one of the most abundantly secreted proteins in the upper airways. BPIFA1 is multifunctional, with antimicrobial, surfactant and lipopolysaccharide-binding activities, as well as established roles in lung hydration. Here, the 2.5 Å resolution crystal structure of BPIFA1 from Mus musculus (mBPIFA1) is presented and compared with those of human BPIFA1 (hBPIFA1) and structural homologs. Structural distinctions between mBPIFA1 and hBPIFA1 suggest potential differences in biological function, including the regulation of a key pulmonary ion channel.

Authors:
;
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Org.:
NSFNIH
OSTI Identifier:
1502202
Resource Type:
Journal Article
Journal Name:
Acta Crystallographica. Section F, Structural Biology Communications
Additional Journal Information:
Journal Volume: 74; Journal Issue: 5; Journal ID: ISSN 2053-230X
Publisher:
International Union of Crystallography
Country of Publication:
United States
Language:
ENGLISH

Citation Formats

Little, Michael S., and Redinbo, Matthew R.. Crystal structure of the mouse innate immunity factor bacterial permeability-increasing family member A1. United States: N. p., 2018. Web. doi:10.1107/S2053230X18004600.
Little, Michael S., & Redinbo, Matthew R.. Crystal structure of the mouse innate immunity factor bacterial permeability-increasing family member A1. United States. doi:10.1107/S2053230X18004600.
Little, Michael S., and Redinbo, Matthew R.. Mon . "Crystal structure of the mouse innate immunity factor bacterial permeability-increasing family member A1". United States. doi:10.1107/S2053230X18004600.
@article{osti_1502202,
title = {Crystal structure of the mouse innate immunity factor bacterial permeability-increasing family member A1},
author = {Little, Michael S. and Redinbo, Matthew R.},
abstractNote = {Bacterial permeability-increasing family member A1 (BPIFA1) is an innate immunity factor and one of the most abundantly secreted proteins in the upper airways. BPIFA1 is multifunctional, with antimicrobial, surfactant and lipopolysaccharide-binding activities, as well as established roles in lung hydration. Here, the 2.5 Å resolution crystal structure of BPIFA1 from Mus musculus (mBPIFA1) is presented and compared with those of human BPIFA1 (hBPIFA1) and structural homologs. Structural distinctions between mBPIFA1 and hBPIFA1 suggest potential differences in biological function, including the regulation of a key pulmonary ion channel.},
doi = {10.1107/S2053230X18004600},
journal = {Acta Crystallographica. Section F, Structural Biology Communications},
issn = {2053-230X},
number = 5,
volume = 74,
place = {United States},
year = {2018},
month = {4}
}