Crystal structure of the mouse innate immunity factor bacterial permeability-increasing family member A1

Little, Michael S.; Redinbo, Matthew R.

doi:10.1107/S2053230X18004600

Crystal structure of the mouse innate immunity factor bacterial permeability-increasing family member A1

Journal Article · 16 April 2018 · Acta Crystallographica. Section F, Structural Biology Communications

DOI:https://doi.org/10.1107/S2053230X18004600· OSTI ID:1502202

Little, Michael S.; Redinbo, Matthew R.

Bacterial permeability-increasing family member A1 (BPIFA1) is an innate immunity factor and one of the most abundantly secreted proteins in the upper airways. BPIFA1 is multifunctional, with antimicrobial, surfactant and lipopolysaccharide-binding activities, as well as established roles in lung hydration. Here, the 2.5 Å resolution crystal structure of BPIFA1 from Mus musculus (mBPIFA1) is presented and compared with those of human BPIFA1 (hBPIFA1) and structural homologs. Structural distinctions between mBPIFA1 and hBPIFA1 suggest potential differences in biological function, including the regulation of a key pulmonary ion channel.

Research Organization:: Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Organization:: NSFNIH

OSTI ID:: 1502202

Journal Information:: Acta Crystallographica. Section F, Structural Biology Communications, Vol. 74, Issue 5; ISSN 2053-230X

Publisher:: International Union of Crystallography

Country of Publication:: United States

Language:: ENGLISH

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