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Title: Molecularly Imprinted Polymers for Selective Analysis of Chemical Warfare Surrogate and Nuclear Signature Compounds in Complex Matrices

Abstract

This paper describes the preparation and evaluation of molecularly imprinted polymers (MIPs) that display specificity toward diisopropyl methylphosphonate (DIMP) and tributyl phosphate (TBP). Polymer activity was assessed by solid-phase extraction and high-performance liquid chromatography experiments. Both DIMP- and TBP-specific MIPs selectively retained their targets relative to a nonimprinted control. Proof-of-principle experiments demonstrated highly selective analysis of the targets from fortified complex matrix samples (diesel fuel, gasoline, and air extract concentrate). The retained MIP fractions gave near quantitative recovery of the target analytes with very low matrix background content. The same fraction from the control sorbent was less pure and recovered only about half of the analyte.

Authors:
Publication Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
15020520
Report Number(s):
PNNL-SA-39115
TRN: US200521%%166
DOE Contract Number:  
AC05-76RL01830
Resource Type:
Journal Article
Resource Relation:
Journal Name: Journal of Separation Science; Journal Volume: 28
Country of Publication:
United States
Language:
English
Subject:
02 PETROLEUM; 45 MILITARY TECHNOLOGY, WEAPONRY, AND NATIONAL DEFENSE; CHEMICAL WARFARE; EVALUATION; GASOLINE; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY; MATRICES; POLYMERS; SPECIFICITY; TARGETS; TBP

Citation Formats

Harvey, Scott D. Molecularly Imprinted Polymers for Selective Analysis of Chemical Warfare Surrogate and Nuclear Signature Compounds in Complex Matrices. United States: N. p., 2005. Web. doi:10.1002/jssc.200301702.
Harvey, Scott D. Molecularly Imprinted Polymers for Selective Analysis of Chemical Warfare Surrogate and Nuclear Signature Compounds in Complex Matrices. United States. doi:10.1002/jssc.200301702.
Harvey, Scott D. Mon . "Molecularly Imprinted Polymers for Selective Analysis of Chemical Warfare Surrogate and Nuclear Signature Compounds in Complex Matrices". United States. doi:10.1002/jssc.200301702.
@article{osti_15020520,
title = {Molecularly Imprinted Polymers for Selective Analysis of Chemical Warfare Surrogate and Nuclear Signature Compounds in Complex Matrices},
author = {Harvey, Scott D.},
abstractNote = {This paper describes the preparation and evaluation of molecularly imprinted polymers (MIPs) that display specificity toward diisopropyl methylphosphonate (DIMP) and tributyl phosphate (TBP). Polymer activity was assessed by solid-phase extraction and high-performance liquid chromatography experiments. Both DIMP- and TBP-specific MIPs selectively retained their targets relative to a nonimprinted control. Proof-of-principle experiments demonstrated highly selective analysis of the targets from fortified complex matrix samples (diesel fuel, gasoline, and air extract concentrate). The retained MIP fractions gave near quantitative recovery of the target analytes with very low matrix background content. The same fraction from the control sorbent was less pure and recovered only about half of the analyte.},
doi = {10.1002/jssc.200301702},
journal = {Journal of Separation Science},
number = ,
volume = 28,
place = {United States},
year = {Mon Aug 01 00:00:00 EDT 2005},
month = {Mon Aug 01 00:00:00 EDT 2005}
}