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Title: Monolayer-Protected Gold Nanoparticles as a Stationary Phase for Open Tubular Gas Chromatography

Abstract

The use of a thin film of monolayer protected gold nanoparticles (MPNs) as a stationary phase for gas chromatography (GC) is reported. Dodecanethiol-protected gold nanoparticles were prepared and characterized. Deposition of a MPN film was successfully completed within a 2 m, 530 {micro}m (i.d.) deactivated silica capillary using gravity to force a plug of solution containing the MPN material through the capillary for deposition. The presence of a thin MPN film on the GC capillary inside wall was confirmed with SEM analysis with an average film thickness of 60.7 nm measured. The retention behavior of the dodecanethiol MPN stationary phase was studied using four different classes of compounds (alkanes, alcohols, aromatics and ketones) and their retention orders were compared to a commercially available column (AT-1, 100 nm phase thickness). The separation of an eight-component mixture was performed using both isothermal and temperature programming separation methods with the novel dodecanethiol MPN phase. The isothermal separation was then objectively compared to the commercial AT-1 stationary phase column using the same experimental parameters. The commercial column had an efficiency, N, of 6200 (k{prime} = 0.33) while the dodecanethiol MPN stationary phase had an efficiency, N, of 5700 (k{prime} = 0.21) for the samemore » analyte, octane. The reduced plate height, h, for this same analyte was found to be less than 1 at the optimum linear flow velocity. Based upon the efficiencies and reduced plate height studies as a function of linear flow velocity, we conclude that the MPN stationary phase operated at nearly the optimum possible performance level. The robustness of the MPN phase is also discussed with consistent performance observed over several months. Overall, the use of monolayer protected gold nanoparticles as gas chromatographic stationary phase materials appears promising.« less

Authors:
; ; ;
Publication Date:
Research Org.:
Pacific Northwest National Laboratory (PNNL), Richland, WA (US), Environmental Molecular Sciences Laboratory (EMSL)
Sponsoring Org.:
USDOE
OSTI Identifier:
15010344
Report Number(s):
PNNL-SA-38968
3450
DOE Contract Number:  
AC05-76RL01830
Resource Type:
Journal Article
Journal Name:
Analytical Chemistry, 75(17):4558-4564
Additional Journal Information:
Journal Name: Analytical Chemistry, 75(17):4558-4564
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; environmental molecular sciences laboratory

Citation Formats

Gross, Gwen M, Nelson, David A, Grate, Jay W, and Synovec, Robert E. Monolayer-Protected Gold Nanoparticles as a Stationary Phase for Open Tubular Gas Chromatography. United States: N. p., 2003. Web. doi:10.1021/ac030112j.
Gross, Gwen M, Nelson, David A, Grate, Jay W, & Synovec, Robert E. Monolayer-Protected Gold Nanoparticles as a Stationary Phase for Open Tubular Gas Chromatography. United States. doi:10.1021/ac030112j.
Gross, Gwen M, Nelson, David A, Grate, Jay W, and Synovec, Robert E. Mon . "Monolayer-Protected Gold Nanoparticles as a Stationary Phase for Open Tubular Gas Chromatography". United States. doi:10.1021/ac030112j.
@article{osti_15010344,
title = {Monolayer-Protected Gold Nanoparticles as a Stationary Phase for Open Tubular Gas Chromatography},
author = {Gross, Gwen M and Nelson, David A and Grate, Jay W and Synovec, Robert E},
abstractNote = {The use of a thin film of monolayer protected gold nanoparticles (MPNs) as a stationary phase for gas chromatography (GC) is reported. Dodecanethiol-protected gold nanoparticles were prepared and characterized. Deposition of a MPN film was successfully completed within a 2 m, 530 {micro}m (i.d.) deactivated silica capillary using gravity to force a plug of solution containing the MPN material through the capillary for deposition. The presence of a thin MPN film on the GC capillary inside wall was confirmed with SEM analysis with an average film thickness of 60.7 nm measured. The retention behavior of the dodecanethiol MPN stationary phase was studied using four different classes of compounds (alkanes, alcohols, aromatics and ketones) and their retention orders were compared to a commercially available column (AT-1, 100 nm phase thickness). The separation of an eight-component mixture was performed using both isothermal and temperature programming separation methods with the novel dodecanethiol MPN phase. The isothermal separation was then objectively compared to the commercial AT-1 stationary phase column using the same experimental parameters. The commercial column had an efficiency, N, of 6200 (k{prime} = 0.33) while the dodecanethiol MPN stationary phase had an efficiency, N, of 5700 (k{prime} = 0.21) for the same analyte, octane. The reduced plate height, h, for this same analyte was found to be less than 1 at the optimum linear flow velocity. Based upon the efficiencies and reduced plate height studies as a function of linear flow velocity, we conclude that the MPN stationary phase operated at nearly the optimum possible performance level. The robustness of the MPN phase is also discussed with consistent performance observed over several months. Overall, the use of monolayer protected gold nanoparticles as gas chromatographic stationary phase materials appears promising.},
doi = {10.1021/ac030112j},
journal = {Analytical Chemistry, 75(17):4558-4564},
number = ,
volume = ,
place = {United States},
year = {2003},
month = {9}
}