Radiation-Induced Genomic Instability: A Role for Secreted Soluble Factors in Communicating the Radiation Response to Non-Irradiated Cells
Journal Article
·
· Journal of Cellular Biochemistry, 92(5):1013-1019
OSTI ID:15008814
Radiation induced genomic instability can be described as the increased rate of genomic alterations occurring in the progeny of an irradiated cell. Its manifestations are the dynamic ongoing production of chrososomal rearrangements, mutations, gene amplifications, transformation, microsatellite instability and/or cell killing. In this prospectus, we present the hypothesis that cellular exposure to ionizing radiation can result in the secretion of soluble factors by irradiated cells and/or their progeny, and that these factors can elicit responses in other cells thereby initiating and perpetuating ongoing genomic instability.
- Research Organization:
- Pacific Northwest National Laboratory (PNNL), Richland, WA (US), Environmental Molecular Sciences Laboratory (EMSL)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC05-76RL01830
- OSTI ID:
- 15008814
- Report Number(s):
- PNNL-SA-41121; 3482; KP1704020; TRN: US200427%%241
- Journal Information:
- Journal of Cellular Biochemistry, 92(5):1013-1019, Vol. 92, Issue 5
- Country of Publication:
- United States
- Language:
- English
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