POSTRANSLATIONAL MODIFICATIONS OF P53: UPSTREAM SIGNALING PATHWAYS.
The p53 tumor suppressor is a tetrameric transcription factor that is posttranslational modified at >20 different sites by phosphorylation, acetylation, or sumoylation in response to various cellular stress conditions. Specific posttranslational modifications, or groups of modifications, that result from the activation of different stress-induced signaling pathways are thought to modulate p53 activity to regulate cell fate by inducing cell cycle arrest, apoptosis, or cellular senescence. Here we review recent progress in characterizing the upstream signaling pathways whose activation in response to various genotoxic and non-genotoxic stresses result in p53 posttranslational modifications.
- Research Organization:
- Brookhaven National Lab. (BNL), Upton, NY (United States)
- Sponsoring Organization:
- DOE/SC (US)
- DOE Contract Number:
- AC02-98CH10886
- OSTI ID:
- 15006423
- Report Number(s):
- BNL-71837-2003-BC; R&D Project: 01-51(LDRD); YN0100000; TRN: US200411%%19
- Resource Relation:
- Other Information: PBD: 23 Oct 2003; Related Information: THE P53 TUMOR SUPPRESSOR PATHWAY AND CANCER
- Country of Publication:
- United States
- Language:
- English
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