Computer Simulation of the Rough Lipopolysaccharide Membrane of Pseudomonas Aeruginosa
Lipopolysaccharides (LPS) form the major constituent of the outer membrane of Gram-negative bacteria, and are believed to play a key role in processes that govern microbial metal binding, microbial adsorption to mineral surfaces, and microbe mediated oxidation/reduction reactions at the bacterial exterior surface. A computational modeling capability is being developed for the study of geochemical reactions at the outer bacterial envelope of Gram-negative bacteria. The understanding of these mechanisms is crucial for the development of successful environmental bioremediation strategies. A molecular model for the rough LPS of Pseudomonas aeruginosa has been designed based on available experimentally determined structural information.
- Research Organization:
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC06-76RL01830
- OSTI ID:
- 15005646
- Report Number(s):
- PNNL-SA-34015; KC0303020; TRN: US200323%%455
- Journal Information:
- Biophysical Journal, 81:1037-1046, Vol. 81
- Country of Publication:
- United States
- Language:
- English
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