MIRD pamphlet no. 16: Techniques for quantitative radiopharmaceutical biodistribution data acquisition and analysis for use in human radiation dose estimates
- Nuclear Physics Enterprizes, Cherry Hill, NJ
- NREL
- Radiation Dosimetry Systems of Oak Ridge, Inc., Knoxville, TN
- Veterans Affairs Medical Center, Palo Alto, CA
- DOE headquarters, Washington, DC
- BATTELLE (PACIFIC NW LAB)
This report describes recommended techniques for radiopharmaceutical biodistribution data acquisition and analysis in human subjects to estimate radiation absorbed dose using the Medical Internal Radiation Dose (MIRD) schema. The document has been prepared in a format to address two audiences: individuals with a primary interest in designing clinical trials who are not experts in dosimetry and individuals with extensive experience with dosimetry-based protocols and calculational methodology. For the first group, the general concepts involved in biodistribution data acquisition are presented, with guidance provided for the number of measurements (data points) required. For those with expertise in dosimetry, highlighted sections, examples and appendices have been included to provide calculational details, as well as references, for the techniques involved. This document is intended also to serve as a guide for the investigator in choosing the appropriate methodologies when acquiring and preparing product data for review by national regulatory agencies. The emphasis is on planar imaging techniques commonly available in most nuclear medicine departments and laboratories.
- Research Organization:
- Pacific Northwest National Lab., Richland, WA (US)
- Sponsoring Organization:
- US Department of Energy (US)
- DOE Contract Number:
- AC06-76RL01830
- OSTI ID:
- 15001638
- Report Number(s):
- PNNL-SA-31620; TRN: US200406%%96
- Journal Information:
- Journal of Nuclear Medicine, Vol. 40, Issue 2; Other Information: PBD: 1 Jan 1999
- Country of Publication:
- United States
- Language:
- English
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