High Resolution 1H NMR Spectroscopy in Rat Liver Using Magic Angle Turning at a 1 Hz Spinning Rate

Journal Article · Sat Dec 01 00:00:00 EST 2001 · Magnetic Resonance in Medicine

OSTI ID:15001300

Hu, Jian Zhi ^[1]; Rommereim, Donald N ^[1]; Wind, Robert A ^[1]

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1. BATTELLE (PACIFIC NW LAB)

It is demonstrated that a high resolution 1H NMR spectrum of excised rat liver can be obtained using the technique of magic angle turning at a sample spinning rate of 1 Hz. A variant of the phase-corrected magic angle turning (PHORMAT) pulse sequence that includes a water suppression segment was developed for the investigation. The spectral resolution achieved with PHORMAT is approaching that obtained from a standard magic angle spinning experiment at a spinning rate of several kHz. With such ultra-slow spinning, tissue and cell damage associated with the standard MAS experiment is minimized or eliminated. The technique is potentially useful for obtaining high-resolution 1H spectra in live animals.

• Research Organization: Pacific Northwest National Lab., Richland, WA (US)
• Sponsoring Organization: US Department of Energy (US)
• DOE Contract Number: AC06-76RL01830
• OSTI ID: 15001300
• Report Number(s): PNNL-SA-35454; KP1402010; TRN: US200404%%8
• Journal Information: Magnetic Resonance in Medicine, Vol. 47, Issue 5; Other Information: PBD: 1 Dec 2001
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
37 INORGANIC
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
RATS
LIVER
RESOLUTION
NMR SPECTRA
HYDROGEN 1
NUCLEAR MAGNETIC RESONANCE