Single-Molecule Conformational Dynamics of Fluctuating Noncovalent DNA-Protein Interactions in DNA Damage Recognition
Journal Article
·
· Journal of the American Chemical Society, 123(37):9184-9185
Single-molecule spectroscopy is a powerful methodology to characterize inhomogeneous samples 1-4 because information may be hidden or lost in conventional ensemble-averaged experiments due to intrinsic sample heterogeneities 5-7. Here we report a single-molecule spectroscopy study that reveals dynamics of fluctuating molecular noncovalent interactions within single protein-DNA complexes. This data will facilitate a molecule-level understanding for the dynamic mechanisms of the damage-recognition process in DNA repair 8.
- Research Organization:
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC05-76RL01830
- OSTI ID:
- 15001297
- Report Number(s):
- PNNL-SA-35320; KC0301020; TRN: US200404%%68
- Journal Information:
- Journal of the American Chemical Society, 123(37):9184-9185, Vol. 123, Issue 37
- Country of Publication:
- United States
- Language:
- English
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