Skip to main content
U.S. Department of Energy
Office of Scientific and Technical Information

Structural basis of small molecule ATPase inhibition of a human mitotic kinesin motor protein

Journal Article · · Scientific Reports

Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
FOREIGN
OSTI ID:
1499801
Journal Information:
Scientific Reports, Vol. 7, Issue 1; ISSN 2045-2322
Publisher:
Nature Publishing Group
Country of Publication:
United States
Language:
ENGLISH

References (59)

Direction determination in the minus-end-directed kinesin motor ncd October 1998
The Kinesin-Related Protein MCAK Is a Microtubule Depolymerase that Forms an ATP-Hydrolyzing Complex at Microtubule Ends February 2003
XKCM1: A Xenopus Kinesin-Related Protein That Regulates Microtubule Dynamics during Mitotic Spindle Assembly January 1996
A kinesin motor in a force-producing conformation January 2010
UFF, a full periodic table force field for molecular mechanics and molecular dynamics simulations December 1992
Decreased Expression of KIFC1 in Human Testes with Globozoospermic Defects September 2016
Kinesin-5 Allosteric Inhibitors Uncouple the Dynamics of Nucleotide, Microtubule, and Neck-Linker Binding Sites November 2014
A standardized kinesin nomenclature: Table I. October 2004
Rotation of the stalk/neck and one head in a new crystal structure of the kinesin motor protein, Ncd October 2003
ARP / wARP and molecular replacement September 2001
Automated and accurate deposition of structures solved by X-ray diffraction to the Protein Data Bank September 2004
Mechanism of Inhibition of Human KSP by Ispinesib March 2008
A structural change in the kinesin motor protein that drives motility December 1999
Discovery and Mechanistic Study of a Small Molecule Inhibitor for Motor Protein KIFC1 August 2013
Structural Basis of New Allosteric Inhibition in Kinesin Spindle Protein Eg5 January 2015
Crystal structure of the kinesin motor domain reveals a structural similarity to myosin April 1996
How good are my data and what is the resolution? June 2013
A new kinesin tree January 2004
Nucleotide-dependent angular change in kinesin motor domain bound to tubulin July 1995
CENP-E Is a Plus End–Directed Kinetochore Motor Required for Metaphase Chromosome Alignment October 1997
The structure of the ternary Eg5–ADP–ispinesib complex September 2012
XDS January 2010
Discovery of a novel inhibitor of kinesin-like protein KIFC1 April 2016
UCSF Chimera?A visualization system for exploratory research and analysis January 2004
Exploring the Intermediate States of ADP−ATP Exchange: A Simulation Study on Eg5 February 2011
Antitumor activity of an allosteric inhibitor of centromere-associated protein-E February 2010
The crystal structure of the minus-end-directed microtubule motor protein ncd reveals variable dimer conformations November 1999
Improving macromolecular atomic models at moderate resolution by automated iterative model building, statistical density modification and refinement June 2003
Structural Insights into a Unique Inhibitor Binding Pocket in Kinesin Spindle Protein January 2013
Mitotic Centromere–associated Kinesin Is Important for Anaphase Chromosome Segregation August 1998
KSP Inhibitors as Antimitotic Agents December 2014
KIFC1 is a novel potential therapeutic target for breast cancer July 2015
Validation of crystallographic models containing TLS or other descriptions of anisotropy July 2010
Inhibition of a Mitotic Motor Protein: Where, How, and Conformational Consequences January 2004
Rapid double 8-nm steps by a kinesin mutant July 2004
Yeast kinesin-8 depolymerizes microtubules in a length-dependent manner August 2006
MolProbity : all-atom structure validation for macromolecular crystallography December 2009
Coot model-building tools for molecular graphics November 2004
Loop L5 Acts as a Conformational Latch in the Mitotic Kinesin Eg5 December 2010
Interaction of the Mitotic Inhibitor Monastrol with Human Kinesin Eg5 January 2003
ATP-competitive inhibitors of the mitotic kinesin KSP that function via an allosteric mechanism October 2007
iotbx.cif : a comprehensive CIF toolbox October 2011
A CEP215–HSET complex links centrosomes with spindle poles and drives centrosome clustering in cancer March 2016
The kinesin-like ncd protein of Drosophila is a minus end-directed microtubule motor December 1990
REFMAC 5 for the refinement of macromolecular crystal structures March 2011
Force generation by kinesin and myosin cytoskeletal motor proteins January 2013
PHENIX: a comprehensive Python-based system for macromolecular structure solution January 2010
A mutant of the motor protein kinesin that moves in both directions on microtubules August 2000
The Drosophila claret segregation protein is a minus-end directed motor molecule October 1990
Decoupling of nucleotide- and microtubule-binding sites in a kinesin mutant December 1998
Crystal structure of the motor domain of the kinesin-related motor ncd April 1996
Identification and partial characterization of mitotic centromere- associated kinesin, a kinesin-related protein that associates with centromeres during mitosis January 1995
A structural pathway for activation of the kinesin motor ATPase June 2001
Determinants of molecular motor directionality October 1999
[20] Processing of X-ray diffraction data collected in oscillation mode January 1997
Design, Synthesis, and Biological Evaluation of an Allosteric Inhibitor of HSET that Targets Cancer Cells with Supernumerary Centrosomes November 2013
The PDB_REDO server for macromolecular structure model optimization May 2014
Phaser crystallographic software July 2007
Evidence that Monastrol Is an Allosteric Inhibitor of the Mitotic Kinesin Eg5 September 2002