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Memory enhancing effects of BPN14770, an allosteric inhibitor of phosphodiesterase-4D, in wild-type and humanized mice

Journal Article · · Neuropsychopharmacology
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Research Organization:
Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
INDUSTRY
OSTI ID:
1499762
Journal Information:
Neuropsychopharmacology, Vol. 43, Issue 11; ISSN 0893-133X
Publisher:
Nature
Country of Publication:
United States
Language:
ENGLISH

References (61)

Loss of calcium/calmodulin responsiveness in adenylate cyclase of rutabaga, a Drosophila learning mutant journal May 1984
Reversal of long-term dendritic spine alterations in Alzheimer disease models journal September 2009
Postsynaptic localization of PSD-95 is regulated by all three pathways downstream of TrkB signaling journal March 2014
Relationships between testing-induced alterations of hippocampal cholinergic activity and memory performance on two spatial tasks in mice journal September 1993
Stereospecific binding of the antidepressant rolipram to brain protein structures journal August 1986
Overexpression of type-1 adenylyl cyclase in mouse forebrain enhances recognition memory and LTP journal May 2004
The role of phosphodiesterases in hippocampal synaptic plasticity journal November 2013
New insights into selective PDE4D inhibitors: 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-dimethylmorpholino)-2-oxoethyl) oxime (GEBR-7b) structural development and promising activities to restore memory impairment journal November 2016
RNA Interference-Mediated Knockdown of Long-Form Phosphodiesterase-4D (PDE4D) Enzyme Reverses Amyloid-β42-Induced Memory Deficits in Mice journal November 2013
Compartmentalized PDE4A5 Signaling Impairs Hippocampal Synaptic Plasticity and Long-Term Memory journal August 2016
Select 3′,5′-cyclic nucleotide phosphodiesterases exhibit altered expression in the aged rodent brain journal February 2014
PRKAR1A and PDE4D Mutations Cause Acrodysostosis but Two Distinct Syndromes with or without GPCR-Signaling Hormone Resistance journal December 2012
A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs. journal October 1993
Muscarinic acetylcholine receptors: signal transduction through multiple effectors. journal May 1995
Phosphorylation and Activation of a cAMP-specific Phosphodiesterase by the cAMP-dependent Protein Kinase: INVOLVEMENT OF SERINE 54 IN THE ENZYME ACTIVATION journal July 1996
Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein journal October 1994
Repeated Methamphetamine Treatment Impairs Recognition Memory Through a Failure of Novelty-Induced ERK1/2 Activation in the Prefrontal Cortex of Mice journal January 2006
Basic roles of key molecules connected with NMDAR signaling pathway on regulating learning and memory and synaptic plasticity journal August 2016
cAMP-specific phosphodiesterase HSPDE4D3 mutants which mimic activation and changes in rolipram inhibition triggered by protein kinase A phosphorylation of Ser-54: generation of a molecular model journal July 1998
A Comprehensive Behavioral Test Battery to Assess Learning and Memory in 129S6/Tg2576 Mice journal January 2016
Differential distribution of PDE4D splice variant mRNAs in rat brain suggests association with specific pathways and presynaptical localization: PDE4D Splice Variants Gene Expression journal July 2002
Multiple Behavior Phenotypes of the Fragile-X Syndrome Mouse Model Respond to Chronic Inhibition of Phosphodiesterase-4D (PDE4D) journal November 2017
Dimerization of the Type 4 cAMP-specific Phosphodiesterases Is Mediated by the Upstream Conserved Regions (UCRs) journal August 2002
Phosphodiesterase-4D Knock-Out and RNA Interference-Mediated Knock-Down Enhance Memory and Increase Hippocampal Neurogenesis via Increased cAMP Signaling journal January 2011
Selective phosphodiesterase inhibitors: a promising target for cognition enhancement journal August 2008
Exome Sequencing Identifies PDE4D Mutations in Acrodysostosis journal April 2012
Exome Sequencing Identifies PDE4D Mutations as Another Cause of Acrodysostosis journal April 2012
Administration of a cAMP Phosphodiesterase 4 Inhibitor Enhances Antidepressant-Induction of BDNF mRNA in Rat Hippocampus journal January 2000
Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety journal December 2009
Deletion of phosphodiesterase 4D in mice shortens α2-adrenoceptor–mediated anesthesia, a behavioral correlate of emesis journal October 2002
Inhibitor Binding to Type 4 Phosphodiesterase (PDE4) Assessed Using [ 3 H]Piclamilast and [ 3 H]Rolipram journal January 2003
Phosphodiesterase-4 (PDE4) Molecular Pharmacology and Alzheimer’s Disease journal November 2014
Antidepressant-Induced Increase in High-Affinity Rolipram Binding Sites in Rat Brain: Dependence on Noradrenergic and Serotonergic Function journal September 2003
Regulation of phosphodiesterase-4 (PDE4) expression in mouse brain by repeated antidepressant treatment: Comparison with rolipram journal June 2006
Identification of Novel Mutations Confirms Pde4d as a Major Gene Causing Acrodysostosis : HUMAN MUTATION journal November 2012
PKA Dynamics in a Drosophila Learning Center: Coincidence Detection by Rutabaga Adenylyl Cyclase and Spatial Regulation by Dunce Phosphodiesterase journal February 2010
Cognitive Neuroscience and the Study of Memory journal March 1998
Persistent improvement in synaptic and cognitive functions in an Alzheimer mouse model after rolipram treatment journal December 2004
Effects of cAMP simulate a late stage of LTP in hippocampal CA1 neurons journal June 1993
Inhibition of phosphodiesterase 2 increases neuronal cGMP, synaptic plasticity and memory performance journal December 2004
Ginsenoside Rb1 promotes neurotransmitter release by modulating phosphorylation of synapsins through a cAMP-dependent protein kinase pathway journal August 2006
Keynote review: Phosphodiesterase-4 as a therapeutic target journal November 2005
Assessing the emetic potential of PDE4 inhibitors in rats journal January 2002
Small Molecule Allosteric Modulators of Phosphodiesterase 4 book January 2011
Regulation of Neurogenesis in Adult Mouse Hippocampus by cAMP and the cAMP Response Element-Binding Protein journal May 2002
Splice variants of the cyclic nucleotide phosphodiesterase PDE4D are differentially expressed and regulated in rat tissue journal June 2005
Memory-enhancing effects of GEBR-32a, a new PDE4D inhibitor holding promise for the treatment of Alzheimer’s disease journal April 2017
Dynamics of Learning-Related cAMP Signaling and Stimulus Integration in the Drosophila Olfactory Pathway journal November 2009
Structural Basis for the Activity of Drugs that Inhibit Phosphodiesterases journal December 2004
Defect in cyclic AMP phosphodiesterase due to the dunce mutation of learning in Drosophila melanogaster journal January 1981
Specific Inhibition of Phosphodiesterase-4B Results in Anxiolysis and Facilitates Memory Acquisition journal August 2015
Targeting the CREB pathway for memory enhancers journal April 2003
Enhanced long-term depression and impaired reversal learning in phosphodiesterase 4B-knockout (PDE4B−/−) mice journal July 2011
Cyclic GMP–mediated memory enhancement in the object recognition test by inhibitors of phosphodiesterase-2 in mice journal November 2015
Cyclic AMP phosphodiesterases are localized in regions of the mouse brain associated with reinforcement, movement, and affect journal May 1999
Enhanced long-term potentiation and impaired learning in phosphodiesterase 4D-knockout ( PDE4D −/− ) mice journal August 2008
Rolipram, a type IV-specific phosphodiesterase inhibitor, facilitates the establishment of long-lasting long-term potentiation and improves memory journal December 1998
RNA interference-mediated phosphodiesterase 4D splice variants knock-down in the prefrontal cortex produces antidepressant-like and cognition-enhancing effects: PDE4D knock-down and behaviour journal January 2013
Different mutations in PDE4D associated with developmental disorders with mirror phenotypes journal November 2013
Structural basis for the design of selective phosphodiesterase 4B inhibitors journal March 2014
dunce, a mutant of Drosophila deficient in learning journal May 1976

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