skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Structural Biology of the HEAT-Like Repeat Family of DNA Glycosylases

 [1];  [1];  [1];  [1]
  1. Department of Biological Sciences, Vanderbilt University, Nashville TN 37232 USA
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Org.:
National Science Foundation (NSF)
OSTI Identifier:
Resource Type:
Journal Article
Journal Name:
Additional Journal Information:
Journal Volume: 40; Journal Issue: 11; Journal ID: ISSN 0265-9247
Country of Publication:
United States

Citation Formats

Shi, Rongxin, Shen, Xing-Xing, Rokas, Antonis, and Eichman, Brandt F. Structural Biology of the HEAT-Like Repeat Family of DNA Glycosylases. United States: N. p., 2018. Web. doi:10.1002/bies.201800133.
Shi, Rongxin, Shen, Xing-Xing, Rokas, Antonis, & Eichman, Brandt F. Structural Biology of the HEAT-Like Repeat Family of DNA Glycosylases. United States. doi:10.1002/bies.201800133.
Shi, Rongxin, Shen, Xing-Xing, Rokas, Antonis, and Eichman, Brandt F. Fri . "Structural Biology of the HEAT-Like Repeat Family of DNA Glycosylases". United States. doi:10.1002/bies.201800133.
title = {Structural Biology of the HEAT-Like Repeat Family of DNA Glycosylases},
author = {Shi, Rongxin and Shen, Xing-Xing and Rokas, Antonis and Eichman, Brandt F.},
abstractNote = {},
doi = {10.1002/bies.201800133},
journal = {BioEssays},
issn = {0265-9247},
number = 11,
volume = 40,
place = {United States},
year = {2018},
month = {9}

Works referenced in this record:

Recent advances in the structural mechanisms of DNA glycosylases
journal, January 2013

  • Brooks, Sonja C.; Adhikary, Suraj; Rubinson, Emily H.
  • Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, Vol. 1834, Issue 1
  • DOI: 10.1016/j.bbapap.2012.10.005

An unprecedented nucleic acid capture mechanism for excision of DNA damage
journal, October 2010

  • Rubinson, Emily H.; Gowda, A. S. Prakasha; Spratt, Thomas E.
  • Nature, Vol. 468, Issue 7322
  • DOI: 10.1038/nature09428

The substrate binding interface of alkylpurine DNA glycosylase AlkD
journal, January 2014

Protein Structure Comparison by Alignment of Distance Matrices
journal, September 1993

Recognition of DNA Adducts by Human Nucleotide Excision Repair: EVIDENCE FOR A THERMODYNAMIC PROBING MECHANISM
journal, October 1996

  • Gunz, Daniela; Hess, Martin T.; Naegeli, Hanspeter
  • Journal of Biological Chemistry, Vol. 271, Issue 41
  • DOI: 10.1074/jbc.271.41.25089

DNA base repair – recognition and initiation of catalysis
journal, November 2009

The La-related protein 1-specific domain repurposes HEAT-like repeats to directly bind a 5′TOP sequence
journal, July 2015

  • Lahr, Roni M.; Mack, Seshat M.; Héroux, Annie
  • Nucleic Acids Research, Vol. 43, Issue 16
  • DOI: 10.1093/nar/gkv748

A New Protein Architecture for Processing Alkylation Damaged DNA: The Crystal Structure of DNA Glycosylase AlkD
journal, August 2008

  • Rubinson, Emily H.; Metz, Audrey H.; O'Quin, Jami
  • Journal of Molecular Biology, Vol. 381, Issue 1
  • DOI: 10.1016/j.jmb.2008.05.078

Base Flipping
journal, June 1998

A new family of proteins related to the HEAT-like repeat DNA glycosylases with affinity for branched DNA structures
journal, July 2013

  • Backe, Paul H.; Simm, Roger; Laerdahl, Jon K.
  • Journal of Structural Biology, Vol. 183, Issue 1
  • DOI: 10.1016/j.jsb.2013.04.007

Structural Basis for a Safety-Belt Mechanism That Anchors Condensin to Chromosomes
journal, October 2017

Structural Basis for the Excision Repair of Alkylation-Damaged DNA
journal, July 1996

The ATRs, ATMs, and TORs Are Giant HEAT Repeat Proteins
journal, January 2003

Crystal Structure of a Human Alkylbase-DNA Repair Enzyme Complexed to DNA
journal, October 1998

Transition-State Analysis of the DNA Repair Enzyme MutY
journal, April 2008

  • McCann, Joe A. B.; Berti, Paul J.
  • Journal of the American Chemical Society, Vol. 130, Issue 17
  • DOI: 10.1021/ja711363s

A Chemical and Kinetic Perspective on Base Excision Repair of DNA
journal, February 2014

  • Schermerhorn, Kelly M.; Delaney, Sarah
  • Accounts of Chemical Research, Vol. 47, Issue 4
  • DOI: 10.1021/ar400275a

DNA bending and a flip-out mechanism for base excision by the helix–hairpin–helix DNA glycosylase, Escherichia coli AlkA
journal, February 2000

  • Hollis, Thomas; Ichikawa, Yoshitaka; Ellenberger, Tom
  • The EMBO Journal, Vol. 19, Issue 4
  • DOI: 10.1093/emboj/19.4.758

AlkB-mediated oxidative demethylation reverses DNA damage in Escherichia coli
journal, September 2002

  • Falnes, Pål Ø.; Johansen, Rune F.; Seeberg, Erling
  • Nature, Vol. 419, Issue 6903
  • DOI: 10.1038/nature01048

Repairing DNA-methylation damage
journal, February 2004

  • Sedgwick, Barbara
  • Nature Reviews Molecular Cell Biology, Vol. 5, Issue 2
  • DOI: 10.1038/nrm1312

Endogenous DNA Damage as a Source of Genomic Instability in Cancer
journal, February 2017

A new protein superfamily includes two novel 3-methyladenine DNA glycosylases from Bacillus cereus , AlkC and AlkD : Alkylation repair in
journal, January 2006

Molecular Mechanisms of Mammalian Global Genome Nucleotide Excision Repair
journal, February 2006

  • Gillet, Ludovic C. J.; Schärer, Orlando D.
  • Chemical Reviews, Vol. 106, Issue 2
  • DOI: 10.1021/cr040483f

The DNA glycosylase AlkD uses a non-base-flipping mechanism to excise bulky lesions
journal, October 2015

  • Mullins, Elwood A.; Shi, Rongxin; Parsons, Zachary D.
  • Nature, Vol. 527, Issue 7577
  • DOI: 10.1038/nature15728

Substrate specificities of bacterial and human AlkB proteins
journal, June 2004

A New Family of HEAT-Like Repeat Proteins Lacking a Critical Substrate Recognition Motif Present in Related DNA Glycosylases
journal, May 2015

Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage
journal, September 2002

  • Trewick, Sarah C.; Henshaw, Timothy F.; Hausinger, Robert P.
  • Nature, Vol. 419, Issue 6903
  • DOI: 10.1038/nature00908

CC-1065 and the Duocarmycins: Understanding their Biological Function through Mechanistic Studies
journal, July 1996

  • Boger, Dale L.; Johnson, Douglas S.
  • Angewandte Chemie International Edition in English, Vol. 35, Issue 1314
  • DOI: 10.1002/anie.199614381

Toxicity and repair of DNA adducts produced by the natural product yatakemycin
journal, July 2017

  • Mullins, Elwood A.; Shi, Rongxin; Eichman, Brandt F.
  • Nature Chemical Biology, Vol. 13, Issue 9
  • DOI: 10.1038/nchembio.2439

A Catalytic Role for C–H/π Interactions in Base Excision Repair by Bacillus cereus DNA Glycosylase AlkD
journal, September 2016

  • Parsons, Zachary D.; Bland, Joshua M.; Mullins, Elwood A.
  • Journal of the American Chemical Society, Vol. 138, Issue 36
  • DOI: 10.1021/jacs.6b07399

A High-Resolution Structure of the Pre-microRNA Nuclear Export Machinery
journal, November 2009

Self-Resistance to an Antitumor Antibiotic: A DNA Glycosylase Triggers the Base-Excision Repair System in Yatakemycin Biosynthesis
journal, September 2012

  • Xu, Hui; Huang, Wei; He, Qing-Li
  • Angewandte Chemie International Edition, Vol. 51, Issue 42
  • DOI: 10.1002/anie.201204109

Fast, scalable generation of high‐quality protein multiple sequence alignments using Clustal Omega
journal, January 2011

  • Sievers, Fabian; Wilm, Andreas; Dineen, David
  • Molecular Systems Biology, Vol. 7, Issue 1
  • DOI: 10.1038/msb.2011.75

3-methyladenine DNA glycosylase I is an unexpected helix-hairpin-helix superfamily member
journal, August 2002

  • Drohat, Alexander C.; Kwon, Keehwan; Krosky, Daniel J.
  • Nature Structural Biology, Vol. 9, Issue 9
  • DOI: 10.1038/nsb829

Nucleic acid recognition by tandem helical repeats
journal, February 2012

  • Rubinson, Emily H.; Eichman, Brandt F.
  • Current Opinion in Structural Biology, Vol. 22, Issue 1
  • DOI: 10.1016/

Structural insight into repair of alkylated DNA by a new superfamily of DNA glycosylases comprising HEAT-like repeats
journal, March 2007

  • Dalhus, Bjørn; Helle, Ina Høydal; Backe, Paul H.
  • Nucleic Acids Research, Vol. 35, Issue 7
  • DOI: 10.1093/nar/gkm039

Comparison of ARM and HEAT protein repeats
journal, May 2001

  • Andrade, Miguel A.; Petosa, Carlo; O’Donoghue, Sean I.
  • Journal of Molecular Biology, Vol. 309, Issue 1
  • DOI: 10.1006/jmbi.2001.4624

Ligand binding by repeat proteins: natural and designed
journal, August 2008

  • Grove, T.; Cortajarena, A.; Regan, L.
  • Current Opinion in Structural Biology, Vol. 18, Issue 4
  • DOI: 10.1016/

Methylating Agents and DNA Repair Responses:  Methylated Bases and Sources of Strand Breaks
journal, December 2006

  • Wyatt, Michael D.; Pittman, Douglas L.
  • Chemical Research in Toxicology, Vol. 19, Issue 12
  • DOI: 10.1021/tx060164e

Interactive Tree Of Life v2: online annotation and display of phylogenetic trees made easy
journal, April 2011

  • Letunic, I.; Bork, P.
  • Nucleic Acids Research, Vol. 39, Issue suppl
  • DOI: 10.1093/nar/gkr201

Direct Reversal of DNA Alkylation Damage
journal, February 2006

  • Mishina, Yukiko; Duguid, Erica M.; He, Chuan
  • Chemical Reviews, Vol. 106, Issue 2
  • DOI: 10.1021/cr0404702

Selective base excision repair of DNA damage by the non‐base‐flipping DNA glycosylase AlkC
journal, September 2017

  • Shi, Rongxin; Mullins, Elwood A.; Shen, Xing‐Xing
  • The EMBO Journal, Vol. 37, Issue 1
  • DOI: 10.15252/embj.201797833

Instability and decay of the primary structure of DNA
journal, April 1993

Analysis of substrate specificity of Schizosaccharomyces pombe Mag1 alkylpurine DNA glycosylase
journal, September 2011

A brief history of the DNA repair field
journal, December 2007

DNA-PKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair
journal, February 2017

  • Sibanda, Bancinyane L.; Chirgadze, Dimitri Y.; Ascher, David B.
  • Science, Vol. 355, Issue 6324
  • DOI: 10.1126/science.aak9654