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Title: Identification of two distinct peptide-binding pockets in the SH3 domain of human mixed-lineage kinase 3

Journal Article · · Journal of Biological Chemistry
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Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
National Institutes of Health (NIH)
OSTI ID:
1499734
Journal Information:
Journal of Biological Chemistry, Vol. 293, Issue 35; ISSN 0021-9258
Publisher:
American Society for Biochemistry and Molecular Biology
Country of Publication:
United States
Language:
ENGLISH

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Cdc42 Induces Activation Loop Phosphorylation and Membrane Targeting of Mixed Lineage Kinase 3 journal October 2005
Hsp90/p50 cdc37 Is Required for Mixed-lineage Kinase (MLK) 3 Signaling journal March 2004
Identification of biologically active peptides that inhibit binding of human CXCL8 to its receptors from a random phage-epitope library journal December 2008
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Regulation of mixed lineage kinase 3 is required for Neurofibromatosis-2-mediated growth suppression in human cancer journal October 2010
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Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes journal February 2014
Nonphosphorylated Peptide Ligands for the Grb2 Src Homology 2 Domain journal November 1997
Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome journal February 2006
Evolution of the neuron-specific alternative splicing product of the c-src proto-oncogene journal September 1989
SH3 domain ligand binding: What's the consensus and where's the specificity? journal May 2012
Efficient Construction of a Large Collection of Phage-Displayed Combinatorial Peptide Libraries journal September 2005
MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation journal July 2004
Dissection of a Signaling Pathway by Which Pathogen-associated Molecular Patterns Recruit the JNK and p38 MAPKs and Trigger Cytokine Release journal June 2007
XDS journal January 2010
The protein interaction network mediated by human SH3 domains journal January 2012
A Combined Experimental and Computational Strategy to Define Protein Interaction Networks for Peptide Recognition Modules journal December 2001
Structural Basis for Specific Binding of the Gads SH3 Domain to an RxxK Motif-Containing SLP-76 Peptide journal February 2003
Zipper-Mediated Oligomerization of the Serine/Threonine Kinase SPRK/MLK-3 Is Not Required for Its Activation by the GTPase Cdc42 But Is Necessary for Its Activation of the JNK Pathway journal June 2000
The Kinase Activation Loop Is the Key to Mixed Lineage Kinase-3 Activation via Both Autophosphorylation and Hematopoetic Progenitor Kinase 1 Phosphorylation journal October 2000
Assembly of Cell Regulatory Systems Through Protein Interaction Domains journal April 2003
A novel peptide-SH3 interaction journal October 1999
Mixed Lineage Kinase-c-Jun N-Terminal Kinase Axis: A Potential Therapeutic Target in Cancer journal April 2013
From peptides to drugs via phage display journal August 1998
Isolation and characterization of e3B1, an eps8 binding protein that regulates cell growth journal January 1997
SH3 domain recognition of a proline-independent tyrosine-based RKxxYxxY motif in immune cell adaptor SKAP55 journal June 2000
Mixed-lineage kinase control of JNK and p38 MAPK pathways journal September 2002
A Specificity Map for the PDZ Domain Family journal September 2008
Novel recognition mode between Vav and Grb2 SH3 domains journal June 2001
Improvements to the Kunkel mutagenesis protocol for constructing primary and secondary phage-display libraries journal September 2012
Differential Recognition Preferences of the Three Src Homology 3 (SH3) Domains from the Adaptor CD2-associated Protein (CD2AP) and Direct Association with Ras and Rab Interactor 3 (RIN3) journal August 2015
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Diverse recognition of non-PxxP peptide ligands by the SH3 domains from p67phox, Grb2 and Pex13p journal August 2002
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Hepatitis C Virus NS5A Inhibits Mixed Lineage Kinase 3 to Block Apoptosis journal July 2013
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Inhibition of Fast Axonal Transport by Pathogenic SOD1 Involves Activation of p38 MAP Kinase journal June 2013
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