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Title: Sterol 14α-Demethylase Structure-Based Design of VNI (( R )- N -(1-(2,4-Dichlorophenyl)-2-(1 H -imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide)) Derivatives To Target Fungal Infections: Synthesis, Biological Evaluation, and Crystallographic Analysis

Authors:
 [1];  [1];  [2];  [3];  [4]; ORCiD logo [3];  [4];  [5];  [6]; ORCiD logo [1]; ORCiD logo [7]
  1. Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States
  2. Synchrotron Research Center, Life Science Collaborative Access Team, Northwestern University, Argonne, Illinois 60439, United States
  3. Vanderbilt Center for Neuroscience Drug Discovery, Franklin, Tennessee 37067, United States
  4. Department of Microbiology, Immunology, and Physiology, Meharry Medical College, Nashville, Tennessee 37208, United States
  5. Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas 79409, United States
  6. Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Siena 53100, Italy
  7. Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States; Center for Structural Biology, Vanderbilt University, Nashville, Tennessee 37232, United States
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Org.:
National Institutes of Health (NIH)
OSTI Identifier:
1499723
Resource Type:
Journal Article
Journal Name:
Journal of Medicinal Chemistry
Additional Journal Information:
Journal Volume: 61; Journal Issue: 13; Journal ID: ISSN 0022-2623
Publisher:
American Chemical Society (ACS)
Country of Publication:
United States
Language:
ENGLISH

Citation Formats

Friggeri, Laura, Hargrove, Tatiana Y., Wawrzak, Zdzislaw, Blobaum, Anna L., Rachakonda, Girish, Lindsley, Craig W., Villalta, Fernando, Nes, W. David, Botta, Maurizio, Guengerich, F. Peter, and Lepesheva, Galina I. Sterol 14α-Demethylase Structure-Based Design of VNI (( R )- N -(1-(2,4-Dichlorophenyl)-2-(1 H -imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide)) Derivatives To Target Fungal Infections: Synthesis, Biological Evaluation, and Crystallographic Analysis. United States: N. p., 2018. Web. doi:10.1021/acs.jmedchem.8b00641.
Friggeri, Laura, Hargrove, Tatiana Y., Wawrzak, Zdzislaw, Blobaum, Anna L., Rachakonda, Girish, Lindsley, Craig W., Villalta, Fernando, Nes, W. David, Botta, Maurizio, Guengerich, F. Peter, & Lepesheva, Galina I. Sterol 14α-Demethylase Structure-Based Design of VNI (( R )- N -(1-(2,4-Dichlorophenyl)-2-(1 H -imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide)) Derivatives To Target Fungal Infections: Synthesis, Biological Evaluation, and Crystallographic Analysis. United States. doi:10.1021/acs.jmedchem.8b00641.
Friggeri, Laura, Hargrove, Tatiana Y., Wawrzak, Zdzislaw, Blobaum, Anna L., Rachakonda, Girish, Lindsley, Craig W., Villalta, Fernando, Nes, W. David, Botta, Maurizio, Guengerich, F. Peter, and Lepesheva, Galina I. Tue . "Sterol 14α-Demethylase Structure-Based Design of VNI (( R )- N -(1-(2,4-Dichlorophenyl)-2-(1 H -imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide)) Derivatives To Target Fungal Infections: Synthesis, Biological Evaluation, and Crystallographic Analysis". United States. doi:10.1021/acs.jmedchem.8b00641.
@article{osti_1499723,
title = {Sterol 14α-Demethylase Structure-Based Design of VNI (( R )- N -(1-(2,4-Dichlorophenyl)-2-(1 H -imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide)) Derivatives To Target Fungal Infections: Synthesis, Biological Evaluation, and Crystallographic Analysis},
author = {Friggeri, Laura and Hargrove, Tatiana Y. and Wawrzak, Zdzislaw and Blobaum, Anna L. and Rachakonda, Girish and Lindsley, Craig W. and Villalta, Fernando and Nes, W. David and Botta, Maurizio and Guengerich, F. Peter and Lepesheva, Galina I.},
abstractNote = {},
doi = {10.1021/acs.jmedchem.8b00641},
journal = {Journal of Medicinal Chemistry},
issn = {0022-2623},
number = 13,
volume = 61,
place = {United States},
year = {2018},
month = {1}
}