skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Structural investigation of human S. aureus- targeting antibodies that bind wall teichoic acid

Authors:
ORCiD logo [1];  [1]; ORCiD logo [1];  [1];  [1];  [1]; ORCiD logo [1]
  1. Department of Structural Biology, Genentech, South San Francisco, CA, USA; Departments of Infectious Diseases, Genentech, South San Francisco, CA, USA; Departments of Antibody Engineering, Genentech, South San Francisco, CA, USA
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Org.:
INDUSTRY
OSTI Identifier:
1499721
Resource Type:
Journal Article
Journal Name:
mAbs
Additional Journal Information:
Journal Volume: 10; Journal Issue: (7) ; 08, 2018; Journal ID: ISSN 1942-0862
Country of Publication:
United States
Language:
ENGLISH

Citation Formats

Fong, Rina, Kajihara, Kimberly, Chen, Matthew, Hotzel, Isidro, Mariathasan, Sanjeev, Hazenbos, Wouter L. W., and Lupardus, Patrick J. Structural investigation of human S. aureus- targeting antibodies that bind wall teichoic acid. United States: N. p., 2018. Web. doi:10.1080/19420862.2018.1501252.
Fong, Rina, Kajihara, Kimberly, Chen, Matthew, Hotzel, Isidro, Mariathasan, Sanjeev, Hazenbos, Wouter L. W., & Lupardus, Patrick J. Structural investigation of human S. aureus- targeting antibodies that bind wall teichoic acid. United States. doi:10.1080/19420862.2018.1501252.
Fong, Rina, Kajihara, Kimberly, Chen, Matthew, Hotzel, Isidro, Mariathasan, Sanjeev, Hazenbos, Wouter L. W., and Lupardus, Patrick J. Mon . "Structural investigation of human S. aureus- targeting antibodies that bind wall teichoic acid". United States. doi:10.1080/19420862.2018.1501252.
@article{osti_1499721,
title = {Structural investigation of human S. aureus- targeting antibodies that bind wall teichoic acid},
author = {Fong, Rina and Kajihara, Kimberly and Chen, Matthew and Hotzel, Isidro and Mariathasan, Sanjeev and Hazenbos, Wouter L. W. and Lupardus, Patrick J.},
abstractNote = {},
doi = {10.1080/19420862.2018.1501252},
journal = {mAbs},
issn = {1942-0862},
number = (7) ; 08, 2018,
volume = 10,
place = {United States},
year = {2018},
month = {8}
}

Works referenced in this record:

Inactivation of the dlt Operon in Staphylococcus aureus Confers Sensitivity to Defensins, Protegrins, and Other Antimicrobial Peptides
journal, March 1999

  • Peschel, Andreas; Otto, Michael; Jack, Ralph W.
  • Journal of Biological Chemistry, Vol. 274, Issue 13
  • DOI: 10.1074/jbc.274.13.8405

An enzyme-based screening system for the rapid assessment of protein N-glycosylation efficiency in yeast
journal, December 2014


Teichoic acids and related cell-wall glycopolymers in Gram-positive physiology and host interactions
journal, March 2008

  • Weidenmaier, Christopher; Peschel, Andreas
  • Nature Reviews Microbiology, Vol. 6, Issue 4
  • DOI: 10.1038/nrmicro1861

Biologic properties and vaccine potential of the staphylococcal poly-N-acetyl glucosamine surface polysaccharide
journal, February 2004


Mechanisms of Neutralization of a Human Anti-α-toxin Antibody
journal, September 2014

  • Oganesyan, Vaheh; Peng, Li; Damschroder, Melissa M.
  • Journal of Biological Chemistry, Vol. 289, Issue 43
  • DOI: 10.1074/jbc.M114.601328

Raxibacumab for the Treatment of Inhalational Anthrax
journal, July 2009

  • Migone, Thi-Sau; Subramanian, G. Mani; Zhong, John
  • New England Journal of Medicine, Vol. 361, Issue 2
  • DOI: 10.1056/NEJMoa0810603

A Revised Pathway Proposed for Staphylococcus aureus Wall Teichoic Acid Biosynthesis Based on In Vitro Reconstitution of the Intracellular Steps
journal, January 2008


Natural Antibodies in Normal Human Serum Inhibit Staphylococcus aureus Capsular Polysaccharide Vaccine Efficacy
journal, July 2012

  • Skurnik, David; Kropec, Andrea; Roux, Damien
  • Clinical Infectious Diseases, Vol. 55, Issue 9
  • DOI: 10.1093/cid/cis624

Innate control of B cell responses
journal, May 2011


Development of a vaccine against Staphylococcus aureus
journal, November 2011


Germline antibody recognition of distinct carbohydrate epitopes
journal, November 2003

  • Nguyen, Hoa P.; Seto, Nina O. L.; MacKenzie, C. Roger
  • Nature Structural & Molecular Biology, Vol. 10, Issue 12
  • DOI: 10.1038/nsb1014

Treatment with Monoclonal Antibodies against Clostridium difficile Toxins
journal, January 2010

  • Lowy, Israel; Molrine, Deborah C.; Leav, Brett A.
  • New England Journal of Medicine, Vol. 362, Issue 3
  • DOI: 10.1056/NEJMoa0907635

Wall Teichoic Acid Function, Biosynthesis, and Inhibition
journal, November 2009

  • Swoboda, Jonathan G.; Campbell, Jennifer; Meredith, Timothy C.
  • ChemBioChem, Vol. 11, Issue 1
  • DOI: 10.1002/cbic.200900557

Coot model-building tools for molecular graphics
journal, November 2004

  • Emsley, Paul; Cowtan, Kevin
  • Acta Crystallographica Section D Biological Crystallography, Vol. 60, Issue 12, p. 2126-2132
  • DOI: 10.1107/S0907444904019158

Tolerogenic therapies in transplantation
journal, January 2012


Challenges of Antibacterial Discovery
journal, January 2011


A graphical user interface to the CCP 4 program suite
journal, June 2003

  • Potterton, Elizabeth; Briggs, Peter; Turkenburg, Maria
  • Acta Crystallographica Section D Biological Crystallography, Vol. 59, Issue 7
  • DOI: 10.1107/S0907444903008126

The dlt Operon in the Biosynthesis of d -Alanyl-Lipoteichoic Acid in Lactobacillus casei
journal, January 1996

  • Neuhaus, Francis C.; Heaton, Michael P.; Debabov, Dmitri V.
  • Microbial Drug Resistance, Vol. 2, Issue 1
  • DOI: 10.1089/mdr.1996.2.77

PHENIX: a comprehensive Python-based system for macromolecular structure solution
journal, January 2010

  • Adams, Paul D.; Afonine, Pavel V.; Bunkóczi, Gábor
  • Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 2, p. 213-221
  • DOI: 10.1107/S0907444909052925

A Continuum of Anionic Charge: Structures and Functions of D-Alanyl-Teichoic Acids in Gram-Positive Bacteria
journal, December 2003


Antibody-Drug Conjugates in Cancer Therapy
journal, January 2013


Resistance or decreased susceptibility to glycopeptides, daptomycin, and linezolid in methicillin-resistant Staphylococcus aureus
journal, October 2010

  • Nannini, Esteban; Murray, Barbara E.; Arias, Cesar A.
  • Current Opinion in Pharmacology, Vol. 10, Issue 5
  • DOI: 10.1016/j.coph.2010.06.006

Taking aim at wall teichoic acid synthesis: new biology and new leads for antibiotics
journal, October 2013

  • Sewell, Edward WC; Brown, Eric D.
  • The Journal of Antibiotics, Vol. 67, Issue 1
  • DOI: 10.1038/ja.2013.100

Glycosylation of Wall Teichoic Acid in Staphylococcus aureus by TarM
journal, February 2010

  • Xia, Guoqing; Maier, Lisa; Sanchez-Carballo, Patricia
  • Journal of Biological Chemistry, Vol. 285, Issue 18
  • DOI: 10.1074/jbc.M109.096172

The More You Look, the More You Find: Effects of Hepatitis C Virus Testing Interval on Reinfection Incidence and Clearance and Implications for Future Vaccine Study Design
journal, March 2012

  • Vickerman, Peter; Grebely, Jason; Dore, Gregory J.
  • The Journal of Infectious Diseases, Vol. 205, Issue 9
  • DOI: 10.1093/infdis/jis213

Staphylococcus aureus Infections
journal, August 1998


Novel Staphylococcal Glycosyltransferases SdgA and SdgB Mediate Immunogenicity and Protection of Virulence-Associated Cell Wall Proteins
journal, October 2013


Carbohydrate−π Interactions: What Are They Worth?
journal, November 2008

  • Laughrey, Zachary R.; Kiehna, Sarah E.; Riemen, Alex J.
  • Journal of the American Chemical Society, Vol. 130, Issue 44
  • DOI: 10.1021/ja803960x

A multifunctional bispecific antibody protects against Pseudomonas aeruginosa
journal, November 2014


Serum therapy revisited: animal models of infection and development of passive antibody therapy.
journal, August 1994

  • Casadevall, A.; Scharff, M. D.
  • Antimicrobial Agents and Chemotherapy, Vol. 38, Issue 8
  • DOI: 10.1128/AAC.38.8.1695

XDS
journal, January 2010

  • Kabsch, Wolfgang
  • Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 2
  • DOI: 10.1107/S0907444909047337

Methicillin resistance in Staphylococcus aureus requires glycosylated wall teichoic acids
journal, October 2012

  • Brown, S.; Xia, G.; Luhachack, L. G.
  • Proceedings of the National Academy of Sciences, Vol. 109, Issue 46
  • DOI: 10.1073/pnas.1209126109

The Emerging Infections Network Electronic Mail Conference and Web Page
journal, January 2001

  • Yu, V. L.; Strausbaugh, L. J.; Liedtke, L. A.
  • Clinical Infectious Diseases, Vol. 32, Issue 2
  • DOI: 10.1086/318467

Platforms for antibiotic discovery
journal, April 2013

  • Lewis, Kim
  • Nature Reviews Drug Discovery, Vol. 12, Issue 5
  • DOI: 10.1038/nrd3975

Isolation of Human Antibody Repertoires with Preservation of the Natural Heavy and Light Chain Pairing
journal, May 2006

  • Meijer, Per-Johan; Andersen, Peter S.; Haahr Hansen, Margit
  • Journal of Molecular Biology, Vol. 358, Issue 3
  • DOI: 10.1016/j.jmb.2006.02.040

An 8‐Year‐Old Boy with Fever, Axillary Ulcerative Lesion, and Altered Mental Status
journal, May 2009

  • Page, Jamie; Wittler, Robert R.
  • Clinical Infectious Diseases, Vol. 48, Issue 9
  • DOI: 10.1086/597588

A Trojan horse with a sweet tooth
journal, June 1995

  • Wilson, Ian A.; Stanfield, Robyn L.
  • Nature Structural & Molecular Biology, Vol. 2, Issue 6
  • DOI: 10.1038/nsb0695-433