skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor

Authors:
; ; ; ; ; ; ; ; ; ORCiD logo; ORCiD logo
Publication Date:
Research Org.:
Brookhaven National Lab. (BNL), Upton, NY (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)
OSTI Identifier:
1499579
Report Number(s):
BNL-209582-2018-JACI
Journal ID: ISSN 0027-8424
DOE Contract Number:  
SC0012704
Resource Type:
Journal Article
Journal Name:
Proceedings of the National Academy of Sciences of the United States of America
Additional Journal Information:
Journal Volume: 115; Journal Issue: 26; Journal ID: ISSN 0027-8424
Publisher:
National Academy of Sciences, Washington, DC (United States)
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE

Citation Formats

Yang, Jie, Liu, Zhonghua, Wang, Chuanping, Yang, Rui, Rathkey, Joseph K., Pinkard, Otis W., Shi, Wuxian, Chen, Yinghua, Dubyak, George R., Abbott, Derek W., and Xiao, Tsan Sam. Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor. United States: N. p., 2018. Web. doi:10.1073/pnas.1800562115.
Yang, Jie, Liu, Zhonghua, Wang, Chuanping, Yang, Rui, Rathkey, Joseph K., Pinkard, Otis W., Shi, Wuxian, Chen, Yinghua, Dubyak, George R., Abbott, Derek W., & Xiao, Tsan Sam. Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor. United States. doi:10.1073/pnas.1800562115.
Yang, Jie, Liu, Zhonghua, Wang, Chuanping, Yang, Rui, Rathkey, Joseph K., Pinkard, Otis W., Shi, Wuxian, Chen, Yinghua, Dubyak, George R., Abbott, Derek W., and Xiao, Tsan Sam. Mon . "Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor". United States. doi:10.1073/pnas.1800562115.
@article{osti_1499579,
title = {Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor},
author = {Yang, Jie and Liu, Zhonghua and Wang, Chuanping and Yang, Rui and Rathkey, Joseph K. and Pinkard, Otis W. and Shi, Wuxian and Chen, Yinghua and Dubyak, George R. and Abbott, Derek W. and Xiao, Tsan Sam},
abstractNote = {},
doi = {10.1073/pnas.1800562115},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
issn = {0027-8424},
number = 26,
volume = 115,
place = {United States},
year = {2018},
month = {6}
}

Works referenced in this record:

Human ICE/CED-3 Protease Nomenclature
journal, October 1996


Mechanisms of Caspase Activation and Inhibition during Apoptosis
journal, March 2002


Crystal Structure of Procaspase-1 Zymogen Domain Reveals Insight into Inflammatory Caspase Autoactivation
journal, December 2008

  • Elliott, J. Michael; Rouge, Lionel; Wiesmann, Christian
  • Journal of Biological Chemistry, Vol. 284, Issue 10
  • DOI: 10.1074/jbc.M806121200

Non-canonical inflammasome activation targets caspase-11
journal, October 2011

  • Kayagaki, Nobuhiko; Warming, Søren; Lamkanfi, Mohamed
  • Nature, Vol. 479, Issue 7371
  • DOI: 10.1038/nature10558

Structures of the Gasdermin D C-Terminal Domains Reveal Mechanisms of Autoinhibition
journal, May 2018


Caspase inhibitors
journal, November 1999


Inefficient star formation in extremely metal poor galaxies
journal, October 2014


Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32
journal, April 1996

  • Slee, Elizabeth A.; Zhu, Huijun; Chow, Sek C.
  • Biochemical Journal, Vol. 315, Issue 1
  • DOI: 10.1042/bj3150021

GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes
journal, June 2016

  • Aglietti, Robin A.; Estevez, Alberto; Gupta, Aaron
  • Proceedings of the National Academy of Sciences, Vol. 113, Issue 28
  • DOI: 10.1073/pnas.1607769113

Pyroptosis: host cell death and inflammation
journal, February 2009

  • Bergsbaken, Tessa; Fink, Susan L.; Cookson, Brad T.
  • Nature Reviews Microbiology, Vol. 7, Issue 2
  • DOI: 10.1038/nrmicro2070

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death
journal, April 2017


Inflammasomes: mechanism of action, role in disease, and therapeutics
journal, June 2015

  • Guo, Haitao; Callaway, Justin B.; Ting, Jenny P-Y
  • Nature Medicine, Vol. 21, Issue 7
  • DOI: 10.1038/nm.3893

Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis
journal, August 2016


Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin
journal, May 2017


Pore-forming activity and structural autoinhibition of the gasdermin family
journal, June 2016


Caspases and their substrates
journal, May 2017

  • Julien, Olivier; Wells, James A.
  • Cell Death & Differentiation, Vol. 24, Issue 8
  • DOI: 10.1038/cdd.2017.44

The Inflammasome
journal, August 2002


The protein structures that shape caspase activity, specificity, activation and inhibition
journal, November 2004

  • Fuentes-Prior, Pablo; Salvesen, Guy S.
  • Biochemical Journal, Vol. 384, Issue 2
  • DOI: 10.1042/BJ20041142

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
journal, September 2015


GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death
journal, July 2016

  • Sborgi, Lorenzo; Rühl, Sebastian; Mulvihill, Estefania
  • The EMBO Journal, Vol. 35, Issue 16
  • DOI: 10.15252/embj.201694696

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
journal, February 2015

  • Coll, Rebecca C.; Robertson, Avril A. B.; Chae, Jae Jin
  • Nature Medicine, Vol. 21, Issue 3
  • DOI: 10.1038/nm.3806

A common allosteric site and mechanism in caspases
journal, May 2006

  • Scheer, J. M.; Romanowski, M. J.; Wells, J. A.
  • Proceedings of the National Academy of Sciences, Vol. 103, Issue 20
  • DOI: 10.1073/pnas.0602571103

Proteolytic Processing of Interleukin-1 Family Cytokines: Variations on a Common Theme
journal, June 2015


Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
journal, September 2015

  • Kayagaki, Nobuhiko; Stowe, Irma B.; Lee, Bettina L.
  • Nature, Vol. 526, Issue 7575
  • DOI: 10.1038/nature15541

Caspase-7 uses an exosite to promote poly(ADP ribose) polymerase 1 proteolysis
journal, March 2012

  • Boucher, D.; Blais, V.; Denault, J. -B.
  • Proceedings of the National Academy of Sciences, Vol. 109, Issue 15
  • DOI: 10.1073/pnas.1200934109

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion
journal, November 2015

  • He, Wan-ting; Wan, Haoqiang; Hu, Lichen
  • Cell Research, Vol. 25, Issue 12
  • DOI: 10.1038/cr.2015.139

Structure insight of GSDMD reveals the basis of GSDMD autoinhibition in cell pyroptosis
journal, September 2017

  • Kuang, Siyun; Zheng, Jun; Yang, Hui
  • Proceedings of the National Academy of Sciences, Vol. 114, Issue 40
  • DOI: 10.1073/pnas.1708194114

Inhibition of Human Caspases by Peptide-based and Macromolecular Inhibitors
journal, December 1998

  • Garcia-Calvo, Margarita; Peterson, Erin P.; Leiting, Barbara
  • Journal of Biological Chemistry, Vol. 273, Issue 49
  • DOI: 10.1074/jbc.273.49.32608

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
journal, July 2016

  • Liu, Xing; Zhang, Zhibin; Ruan, Jianbin
  • Nature, Vol. 535, Issue 7610
  • DOI: 10.1038/nature18629

Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock
journal, September 2013


Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4
journal, July 2013


Activation and regulation of the inflammasomes
journal, May 2013

  • Latz, Eicke; Xiao, T. Sam; Stutz, Andrea
  • Nature Reviews Immunology, Vol. 13, Issue 6
  • DOI: 10.1038/nri3452

Caspases in apoptosis and beyond
journal, October 2008


Crystal Structures of a Ligand-free and Malonate-Bound Human Caspase-1
journal, August 2004