Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor

doi:10.1073/pnas.1800562115

Title: Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor

Authors:

Yang, Jie; Liu, Zhonghua; Wang, Chuanping; Yang, Rui; Rathkey, Joseph K.; Pinkard, Otis W.; Shi, Wuxian; Chen, Yinghua; Dubyak, George R.;

;

Publication Date:: 2018-06-11

Research Org.:: Brookhaven National Lab. (BNL), Upton, NY (United States)

Sponsoring Org.:: USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)

OSTI Identifier:: 1499579

Report Number(s):: BNL-209582-2018-JACI
Journal ID: ISSN 0027-8424

DOE Contract Number:: SC0012704

Resource Type:: Journal Article

Journal Name:: Proceedings of the National Academy of Sciences of the United States of America

Additional Journal Information:: Journal Volume: 115; Journal Issue: 26; Journal ID: ISSN 0027-8424

Publisher:: National Academy of Sciences, Washington, DC (United States)

Country of Publication:: United States

Language:: English

Subject:: 36 MATERIALS SCIENCE

Citation Formats


                    Yang, Jie, Liu, Zhonghua, Wang, Chuanping, Yang, Rui, Rathkey, Joseph K., Pinkard, Otis W., Shi, Wuxian, Chen, Yinghua, Dubyak, George R., Abbott, Derek W., and Xiao, Tsan Sam. Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor.  United States: N. p., 2018. 
        Web.  doi:10.1073/pnas.1800562115.

Copy to clipboard


                    Yang, Jie, Liu, Zhonghua, Wang, Chuanping, Yang, Rui, Rathkey, Joseph K., Pinkard, Otis W., Shi, Wuxian, Chen, Yinghua, Dubyak, George R., Abbott, Derek W., & Xiao, Tsan Sam. Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor.  United States.  doi:10.1073/pnas.1800562115.

Copy to clipboard


                    Yang, Jie, Liu, Zhonghua, Wang, Chuanping, Yang, Rui, Rathkey, Joseph K., Pinkard, Otis W., Shi, Wuxian, Chen, Yinghua, Dubyak, George R., Abbott, Derek W., and Xiao, Tsan Sam. Mon .  
        "Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor".  United States.  doi:10.1073/pnas.1800562115.

Copy to clipboard


                    
@article{osti_1499579,

  title        = {Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor},

  author       = {Yang, Jie and Liu, Zhonghua and Wang, Chuanping and Yang, Rui and Rathkey, Joseph K. and Pinkard, Otis W. and Shi, Wuxian and Chen, Yinghua and Dubyak, George R. and Abbott, Derek W. and Xiao, Tsan Sam},

  abstractNote = {},

  doi          = {10.1073/pnas.1800562115},

  journal      = {Proceedings of the National Academy of Sciences of the United States of America},

  issn         = {0027-8424},

  number       = 26,

  volume       = 115,

  place        = {United States},

  year         = {2018},

  month        = {6}

}

Copy to clipboard

Journal Article:

DOI: 10.1073/pnas.1800562115

Other availability

Find in Google Scholar

Search WorldCat to find libraries that may hold this journal

Save / Share:

Export Metadata

Save to My Library

Works referenced in this record:

Human ICE/CED-3 Protease Nomenclature
journal, October 1996

Alnemri, Emad S.; Livingston, David J.; Nicholson, Donald W.
Cell, Vol. 87, Issue 2
DOI: 10.1016/S0092-8674(00)81334-3

Mechanisms of Caspase Activation and Inhibition during Apoptosis
journal, March 2002

Shi, Yigong
Molecular Cell, Vol. 9, Issue 3
DOI: 10.1016/S1097-2765(02)00482-3

Crystal Structure of Procaspase-1 Zymogen Domain Reveals Insight into Inflammatory Caspase Autoactivation
journal, December 2008

Elliott, J. Michael; Rouge, Lionel; Wiesmann, Christian
Journal of Biological Chemistry, Vol. 284, Issue 10
DOI: 10.1074/jbc.M806121200

Non-canonical inflammasome activation targets caspase-11
journal, October 2011

Kayagaki, Nobuhiko; Warming, Søren; Lamkanfi, Mohamed
Nature, Vol. 479, Issue 7371
DOI: 10.1038/nature10558

Structures of the Gasdermin D C-Terminal Domains Reveal Mechanisms of Autoinhibition
journal, May 2018

Liu, Zhonghua; Wang, Chuanping; Rathkey, Joseph K.
Structure, Vol. 26, Issue 5
DOI: 10.1016/j.str.2018.03.002

Caspase inhibitors
journal, November 1999

Ekert, Pg; Silke, J.; Vaux, Dl
Cell Death & Differentiation, Vol. 6, Issue 11
DOI: 10.1038/sj.cdd.4400594

Inefficient star formation in extremely metal poor galaxies
journal, October 2014

Shi, Yong; Armus, Lee; Helou, George
Nature, Vol. 514, Issue 7522
DOI: 10.1038/nature13820

Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32
journal, April 1996

Slee, Elizabeth A.; Zhu, Huijun; Chow, Sek C.
Biochemical Journal, Vol. 315, Issue 1
DOI: 10.1042/bj3150021

GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes
journal, June 2016

Aglietti, Robin A.; Estevez, Alberto; Gupta, Aaron
Proceedings of the National Academy of Sciences, Vol. 113, Issue 28
DOI: 10.1073/pnas.1607769113

Pyroptosis: host cell death and inflammation
journal, February 2009

Bergsbaken, Tessa; Fink, Susan L.; Cookson, Brad T.
Nature Reviews Microbiology, Vol. 7, Issue 2
DOI: 10.1038/nrmicro2070

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death
journal, April 2017

Shi, Jianjin; Gao, Wenqing; Shao, Feng
Trends in Biochemical Sciences, Vol. 42, Issue 4
DOI: 10.1016/j.tibs.2016.10.004

Inflammasomes: mechanism of action, role in disease, and therapeutics
journal, June 2015

Guo, Haitao; Callaway, Justin B.; Ting, Jenny P-Y
Nature Medicine, Vol. 21, Issue 7
DOI: 10.1038/nm.3893

Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis
journal, August 2016

Chen, Xin; He, Wan-ting; Hu, Lichen
Cell Research, Vol. 26, Issue 9
DOI: 10.1038/cr.2016.100

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin
journal, May 2017

Wang, Yupeng; Gao, Wenqing; Shi, Xuyan
Nature, Vol. 547, Issue 7661
DOI: 10.1038/nature22393

Pore-forming activity and structural autoinhibition of the gasdermin family
journal, June 2016

Ding, Jingjin; Wang, Kun; Liu, Wang
Nature, Vol. 535, Issue 7610
DOI: 10.1038/nature18590

Caspases and their substrates
journal, May 2017

Julien, Olivier; Wells, James A.
Cell Death & Differentiation, Vol. 24, Issue 8
DOI: 10.1038/cdd.2017.44

The Inflammasome
journal, August 2002

Martinon, Fabio; Burns, Kimberly; Tschopp, Jürg
Molecular Cell, Vol. 10, Issue 2
DOI: 10.1016/S1097-2765(02)00599-3

The protein structures that shape caspase activity, specificity, activation and inhibition
journal, November 2004

Fuentes-Prior, Pablo; Salvesen, Guy S.
Biochemical Journal, Vol. 384, Issue 2
DOI: 10.1042/BJ20041142

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
journal, September 2015

Shi, Jianjin; Zhao, Yue; Wang, Kun
Nature, Vol. 526, Issue 7575
DOI: 10.1038/nature15514

GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death
journal, July 2016

Sborgi, Lorenzo; Rühl, Sebastian; Mulvihill, Estefania
The EMBO Journal, Vol. 35, Issue 16
DOI: 10.15252/embj.201694696

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
journal, February 2015

Coll, Rebecca C.; Robertson, Avril A. B.; Chae, Jae Jin
Nature Medicine, Vol. 21, Issue 3
DOI: 10.1038/nm.3806

A common allosteric site and mechanism in caspases
journal, May 2006

Scheer, J. M.; Romanowski, M. J.; Wells, J. A.
Proceedings of the National Academy of Sciences, Vol. 103, Issue 20
DOI: 10.1073/pnas.0602571103

Proteolytic Processing of Interleukin-1 Family Cytokines: Variations on a Common Theme
journal, June 2015

Afonina, Inna S.; Müller, Christina; Martin, Seamus J.
Immunity, Vol. 42, Issue 6
DOI: 10.1016/j.immuni.2015.06.003

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
journal, September 2015

Kayagaki, Nobuhiko; Stowe, Irma B.; Lee, Bettina L.
Nature, Vol. 526, Issue 7575
DOI: 10.1038/nature15541

Caspase-7 uses an exosite to promote poly(ADP ribose) polymerase 1 proteolysis
journal, March 2012

Boucher, D.; Blais, V.; Denault, J. -B.
Proceedings of the National Academy of Sciences, Vol. 109, Issue 15
DOI: 10.1073/pnas.1200934109

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion
journal, November 2015

He, Wan-ting; Wan, Haoqiang; Hu, Lichen
Cell Research, Vol. 25, Issue 12
DOI: 10.1038/cr.2015.139

Structure insight of GSDMD reveals the basis of GSDMD autoinhibition in cell pyroptosis
journal, September 2017

Kuang, Siyun; Zheng, Jun; Yang, Hui
Proceedings of the National Academy of Sciences, Vol. 114, Issue 40
DOI: 10.1073/pnas.1708194114

Inhibition of Human Caspases by Peptide-based and Macromolecular Inhibitors
journal, December 1998

Garcia-Calvo, Margarita; Peterson, Erin P.; Leiting, Barbara
Journal of Biological Chemistry, Vol. 273, Issue 49
DOI: 10.1074/jbc.273.49.32608

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
journal, July 2016

Liu, Xing; Zhang, Zhibin; Ruan, Jianbin
Nature, Vol. 535, Issue 7610
DOI: 10.1038/nature18629

Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock
journal, September 2013

Hagar, J. A.; Powell, D. A.; Aachoui, Y.
Science, Vol. 341, Issue 6151
DOI: 10.1126/science.1240988

Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4
journal, July 2013

Kayagaki, N.; Wong, M. T.; Stowe, I. B.
Science, Vol. 341, Issue 6151
DOI: 10.1126/science.1240248

Activation and regulation of the inflammasomes
journal, May 2013

Latz, Eicke; Xiao, T. Sam; Stutz, Andrea
Nature Reviews Immunology, Vol. 13, Issue 6
DOI: 10.1038/nri3452

Caspases in apoptosis and beyond
journal, October 2008

Li, J.; Yuan, J.
Oncogene, Vol. 27, Issue 48
DOI: 10.1038/onc.2008.297

Crystal Structures of a Ligand-free and Malonate-Bound Human Caspase-1
journal, August 2004

Romanowski, Michael J.; Scheer, Justin M.; O'Brien, Tom
Structure, Vol. 12, Issue 8
DOI: 10.1016/j.str.2004.05.010

Similar records in OSTI.GOV collections:

Kinetic and structural characterization of caspase-3 and caspase-8 inhibition by a novel class of irreversible inhibitors

Journal Article Wang, Zhigang ; Watt, William ; Brooks, Nathan A. ; ... - BBA- Proteins Proteom.

Because of their central role in programmed cell death, the caspases are attractive targets for developing new therapeutics against cancer and autoimmunity, myocardial infarction and ischemic damage, and neurodegenerative diseases. We chose to target caspase-3, an executioner caspase, and caspase-8, an initiator caspase, based on the vast amount of information linking their functions to diseases. Through a structure-based drug design approach, a number of novel {beta}-strand peptidomimetic compounds were synthesized. Kinetic studies of caspase-3 and caspase-8 inhibition were carried out with these urazole ring-containing irreversible peptidomimetics and a known irreversible caspase inhibitor, Z-VAD-fmk. Using a stopped-flow fluorescence assay, we weremore »« less
DOI: 10.1016/j.bbapap.2010.05.007
Novel inhibitors of human leukocyte elastase and cathepsin G. Sequence variants of squash seed protease inhibitor with altered protease selectivity

Journal Article McWherter, C.A. ; Walkenhorst, W.F. ; Glover, G.I. ; ... - Biochemistry; (USA)

Novel peptide inhibitors of human leukocyte elastase (HLE) and cathepsin G (CG) were prepared by solid-phase peptide synthesis of P1 amino acid sequence variants of Curcurbita maxima trypsin inhibitor III (CMTI-III), a 29-residue peptide found in squash seed. A systematic study of P1 variants indicated that P1, Arg, Lys, Leu, Ala, Phe, and Met inhibit trypsin; P1, Val, Ile, Gly, Leu, Ala, Phe, and Met inhibit HLE; P1 Leu, Ala, Phe, and Met inhibit CG and chymotrypsin. Variants with P1, Val, Ile, or Gly were selective inhibitors of HLE, while inhibition of trypsin required P1 amino acids with an unbranchedmore »« less
DOI: 10.1021/bi00440a002
Anti-neuroinflammatory efficacy of the aldose reductase inhibitor FMHM via phospholipase C/protein kinase C-dependent NF-κB and MAPK pathways

Journal Article Zeng, Ke-Wu ; Li, Jun ; Dong, Xin ; ... - Toxicology and Applied Pharmacology

Aldose reductase (AR) has a key role in several inflammatory diseases: diabetes, cancer and cardiovascular diseases. Therefore, AR inhibition seems to be a useful strategy for anti-inflammation therapy. In the central nervous system (CNS), microglial over-activation is considered to be a central event in neuroinflammation. However, the effects of AR inhibition in CNS inflammation and its underlying mechanism of action remain unknown. In the present study, we found that FMHM (a naturally derived AR inhibitor from the roots of Polygala tricornis Gagnep.) showed potent anti-neuroinflammatory effects in vivo and in vitro by inhibiting microglial activation and expression of inflammatory mediators.more »« less
DOI: 10.1016/J.TAAP.2013.08.028
Combination therapy with andrographolide and D-penicillamine enhanced therapeutic advantage over monotherapy with D-penicillamine in attenuating fibrogenic response and cell death in the periportal zone of liver in rats during copper toxicosis

Journal Article Roy, Dijendra Nath ; Sen, Gargi ; Chowdhury, Kaustav Dutta ; ... - Toxicology and Applied Pharmacology

Long treatment regime with D-penicillamine is needed before it can exert clinically meaningful benefits in the treatment of copper toxicosis. The consequence of long-term D-penicillamine treatment is associated with numerous side effects. The limitations of D-penicillamine monotherapy prompted us to search for more effective treatment strategies that could decrease the duration of D-penicillamine therapy. The present study was designed to evaluate the therapeutic potential of D-penicillamine in combination with another hepatoprotective drug, andrographolide in treatment of copper toxicosis in rats. D-penicillamine treatment led to the excretion of copper through urine. Addition of andrographolide to D-penicillamine regime appeared to increase protectionmore »« less
DOI: 10.1016/j.taap.2010.09.027
Dipeptidyl peptidase-4 inhibitor ameliorates early renal injury through its anti-inflammatory action in a rat model of type 1 diabetes

Journal Article Kodera, Ryo, E-mail: kodera@cc.okayama-u.ac.jp ; Shikata, Kenichi ; Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558 ; ... - Biochemical and Biophysical Research Communications

Highlights: •DPP-4 inhibitor decreased urinary albumin excretion in a rat of type 1 diabetes. •DPP-4 inhibitor ameliorated histlogical changes of diabetic nephropathy. •DPP-4 inhibitor has reno-protective effects through anti-inflammatory action. •DPP-4 inhibitor is beneficial on diabetic nephropathy besides lowering blood glucose. -- Abstract: Introduction: Dipeptidyl peptidase-4 (DPP-4) inhibitors are incretin-based drugs in patients with type 2 diabetes. In our previous study, we showed that glucagon-like peptide-1 (GLP-1) receptor agonist has reno-protective effects through anti-inflammatory action. The mechanism of action of DPP-4 inhibitor is different from that of GLP-1 receptor agonists. It is not obvious whether DPP-4 inhibitor prevents the exacerbationmore »« less
DOI: 10.1016/J.BBRC.2013.12.049

Similar Records

Title: Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor

Citation Formats

Human ICE/CED-3 Protease Nomenclature journal, October 1996

Mechanisms of Caspase Activation and Inhibition during Apoptosis journal, March 2002

Crystal Structure of Procaspase-1 Zymogen Domain Reveals Insight into Inflammatory Caspase Autoactivation journal, December 2008

Non-canonical inflammasome activation targets caspase-11 journal, October 2011

Structures of the Gasdermin D C-Terminal Domains Reveal Mechanisms of Autoinhibition journal, May 2018

Caspase inhibitors journal, November 1999

Inefficient star formation in extremely metal poor galaxies journal, October 2014

Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32 journal, April 1996

GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes journal, June 2016

Pyroptosis: host cell death and inflammation journal, February 2009

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death journal, April 2017

Inflammasomes: mechanism of action, role in disease, and therapeutics journal, June 2015

Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis journal, August 2016

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin journal, May 2017

Pore-forming activity and structural autoinhibition of the gasdermin family journal, June 2016

Caspases and their substrates journal, May 2017

The Inflammasome journal, August 2002

The protein structures that shape caspase activity, specificity, activation and inhibition journal, November 2004

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death journal, September 2015

GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death journal, July 2016

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases journal, February 2015

A common allosteric site and mechanism in caspases journal, May 2006

Proteolytic Processing of Interleukin-1 Family Cytokines: Variations on a Common Theme journal, June 2015

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling journal, September 2015

Caspase-7 uses an exosite to promote poly(ADP ribose) polymerase 1 proteolysis journal, March 2012

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion journal, November 2015

Structure insight of GSDMD reveals the basis of GSDMD autoinhibition in cell pyroptosis journal, September 2017

Inhibition of Human Caspases by Peptide-based and Macromolecular Inhibitors journal, December 1998

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores journal, July 2016

Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock journal, September 2013

Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4 journal, July 2013

Activation and regulation of the inflammasomes journal, May 2013

Caspases in apoptosis and beyond journal, October 2008

Crystal Structures of a Ligand-free and Malonate-Bound Human Caspase-1 journal, August 2004

Human ICE/CED-3 Protease Nomenclature
journal, October 1996

Mechanisms of Caspase Activation and Inhibition during Apoptosis
journal, March 2002

Crystal Structure of Procaspase-1 Zymogen Domain Reveals Insight into Inflammatory Caspase Autoactivation
journal, December 2008

Non-canonical inflammasome activation targets caspase-11
journal, October 2011

Structures of the Gasdermin D C-Terminal Domains Reveal Mechanisms of Autoinhibition
journal, May 2018

Caspase inhibitors
journal, November 1999

Inefficient star formation in extremely metal poor galaxies
journal, October 2014

Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32
journal, April 1996

GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes
journal, June 2016

Pyroptosis: host cell death and inflammation
journal, February 2009

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death
journal, April 2017

Inflammasomes: mechanism of action, role in disease, and therapeutics
journal, June 2015

Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis
journal, August 2016

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin
journal, May 2017

Pore-forming activity and structural autoinhibition of the gasdermin family
journal, June 2016

Caspases and their substrates
journal, May 2017

The Inflammasome
journal, August 2002

The protein structures that shape caspase activity, specificity, activation and inhibition
journal, November 2004

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
journal, September 2015

GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death
journal, July 2016

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
journal, February 2015

A common allosteric site and mechanism in caspases
journal, May 2006

Proteolytic Processing of Interleukin-1 Family Cytokines: Variations on a Common Theme
journal, June 2015

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
journal, September 2015

Caspase-7 uses an exosite to promote poly(ADP ribose) polymerase 1 proteolysis
journal, March 2012

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion
journal, November 2015

Structure insight of GSDMD reveals the basis of GSDMD autoinhibition in cell pyroptosis
journal, September 2017

Inhibition of Human Caspases by Peptide-based and Macromolecular Inhibitors
journal, December 1998

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
journal, July 2016

Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock
journal, September 2013

Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4
journal, July 2013

Activation and regulation of the inflammasomes
journal, May 2013

Caspases in apoptosis and beyond
journal, October 2008

Crystal Structures of a Ligand-free and Malonate-Bound Human Caspase-1
journal, August 2004