Large-Scale Production of 119m Te and 119 Sb for Radiopharmaceutical Applications
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- Los Alamos National Laboratory, Los Alamos, New Mexico 87545, United States
- Los Alamos National Laboratory, Los Alamos, New Mexico 87545, United States, University of Iowa, Iowa City, Iowa 52242-1294, United States
- University of Iowa, Iowa City, Iowa 52242-1294, United States
- Los Alamos National Laboratory, Los Alamos, New Mexico 87545, United States, University of Wisconsin, Madison, Wisconsin 53705, United States
Radionuclides find widespread use in medical technologies for treating and diagnosing disease. Among successful and emerging radiotherapeutics, 119Sb has unique potential in targeted therapeutic applications for low-energy electron-emitting isotopes. Unfortunately, developing 119Sb-based drugs has been slow in comparison to other radionuclides, primarily due to limited accessibility. Herein is a production method that overcomes this challenge and expands the available time for large-scale distribution and use. Our approach exploits high flux and fluence from high-energy proton sources to produce longer lived 119mTe. This parent isotope slowly decays to 119Sb, which in turn provides access to 119Sb for longer time periods (in comparison to direct 119Sb production routes). We contribute the target design, irradiation conditions, and a rapid procedure for isolating the 119mTe/119Sb pair. To guide process development and to understand why the procedure was successful, we characterized the Te/Sb separation using Te and Sb K-edge X-ray absorption spectroscopy. The procedure provides low-volume aqueous solutions that have high 119mTe and consequently 119Sb specific activity in a chemically pure form. This procedure has been demonstrated at large-scale (production-sized, Ci quantities), and the product has potential to meet stringent Food and Drug Administration requirements for a 119mTe/119Sb active pharmaceutical ingredient.
- Research Organization:
- Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
- Sponsoring Organization:
- USDOE Office of Science (SC), Basic Energy Sciences (BES); USDOE National Nuclear Security Administration (NNSA); USDOE Laboratory Directed Research and Development (LDRD) Program
- Grant/Contract Number:
- 89233218CNA000001; SC141099; AC02-76SF00515
- OSTI ID:
- 1496496
- Alternate ID(s):
- OSTI ID: 1499362; OSTI ID: 1512781
- Report Number(s):
- LA-UR-18-31048
- Journal Information:
- ACS Central Science, Journal Name: ACS Central Science; ISSN 2374-7943
- Publisher:
- American Chemical Society (ACS)Copyright Statement
- Country of Publication:
- United States
- Language:
- English
Web of Science
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