skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Substrate-assisted enzymatic formation of lysinoalanine in duramycin

Authors:
; ; ; ; ;
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Org.:
National Institutes of Health (NIH)
OSTI Identifier:
1498429
Resource Type:
Journal Article
Journal Name:
Nature Chemical Biology
Additional Journal Information:
Journal Volume: 14; Journal Issue: 10; Journal ID: ISSN 1552-4450
Publisher:
Nature Publishing Group
Country of Publication:
United States
Language:
ENGLISH

Citation Formats

An, Linna, Cogan, Dillon P., Navo, Claudio D., Jiménez-Osés, Gonzalo, Nair, Satish K., and van der Donk, Wilfred A. Substrate-assisted enzymatic formation of lysinoalanine in duramycin. United States: N. p., 2018. Web. doi:10.1038/s41589-018-0122-4.
An, Linna, Cogan, Dillon P., Navo, Claudio D., Jiménez-Osés, Gonzalo, Nair, Satish K., & van der Donk, Wilfred A. Substrate-assisted enzymatic formation of lysinoalanine in duramycin. United States. doi:10.1038/s41589-018-0122-4.
An, Linna, Cogan, Dillon P., Navo, Claudio D., Jiménez-Osés, Gonzalo, Nair, Satish K., and van der Donk, Wilfred A. Mon . "Substrate-assisted enzymatic formation of lysinoalanine in duramycin". United States. doi:10.1038/s41589-018-0122-4.
@article{osti_1498429,
title = {Substrate-assisted enzymatic formation of lysinoalanine in duramycin},
author = {An, Linna and Cogan, Dillon P. and Navo, Claudio D. and Jiménez-Osés, Gonzalo and Nair, Satish K. and van der Donk, Wilfred A.},
abstractNote = {},
doi = {10.1038/s41589-018-0122-4},
journal = {Nature Chemical Biology},
issn = {1552-4450},
number = 10,
volume = 14,
place = {United States},
year = {2018},
month = {9}
}

Works referenced in this record:

SPFP: Speed without compromise—A mixed precision model for GPU accelerated molecular dynamics simulations
journal, February 2013

  • Le Grand, Scott; Götz, Andreas W.; Walker, Ross C.
  • Computer Physics Communications, Vol. 184, Issue 2
  • DOI: 10.1016/j.cpc.2012.09.022

The Buccaneer software for automated model building. 1. Tracing protein chains
journal, August 2006


Enzyme Function Initiative-Enzyme Similarity Tool (EFI-EST): A web tool for generating protein sequence similarity networks
journal, August 2015

  • Gerlt, John A.; Bouvier, Jason T.; Davidson, Daniel B.
  • Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, Vol. 1854, Issue 8
  • DOI: 10.1016/j.bbapap.2015.04.015

Nine Post-translational Modifications during the Biosynthesis of Cinnamycin
journal, August 2011

  • Ökesli, Ayşe; Cooper, Lisa E.; Fogle, Emily J.
  • Journal of the American Chemical Society, Vol. 133, Issue 34
  • DOI: 10.1021/ja205783f

Discovery of a widely distributed toxin biosynthetic gene cluster
journal, March 2008

  • Lee, S. W.; Mitchell, D. A.; Markley, A. L.
  • Proceedings of the National Academy of Sciences, Vol. 105, Issue 15
  • DOI: 10.1073/pnas.0801338105

Virion-associated phosphatidylethanolamine promotes TIM1-mediated infection by Ebola, dengue, and West Nile viruses
journal, November 2015

  • Richard, Audrey Stéphanie; Zhang, Adam; Park, Sun-Jin
  • Proceedings of the National Academy of Sciences, Vol. 112, Issue 47
  • DOI: 10.1073/pnas.1508095112

Routine Access to Millisecond Time Scale Events with Accelerated Molecular Dynamics
journal, August 2012

  • Pierce, Levi C. T.; Salomon-Ferrer, Romelia; Augusto F. de Oliveira, Cesar
  • Journal of Chemical Theory and Computation, Vol. 8, Issue 9
  • DOI: 10.1021/ct300284c

Particle mesh Ewald: An N ⋅log( N ) method for Ewald sums in large systems
journal, June 1993

  • Darden, Tom; York, Darrin; Pedersen, Lee
  • The Journal of Chemical Physics, Vol. 98, Issue 12
  • DOI: 10.1063/1.464397

Curvature-Dependent Recognition of Ethanolamine Phospholipids by Duramycin and Cinnamycin
journal, September 2007


An approach to computing electrostatic charges for molecules
journal, April 1984

  • Singh, U. Chandra; Kollman, Peter A.
  • Journal of Computational Chemistry, Vol. 5, Issue 2
  • DOI: 10.1002/jcc.540050204

Lipid distribution and transport across cellular membranes
journal, April 2001

  • Pomorski, Thomas; Hrafnsdóttir, Sigrún; Devaux, Philippe F.
  • Seminars in Cell & Developmental Biology, Vol. 12, Issue 2
  • DOI: 10.1006/scdb.2000.0231

Dali server: conservation mapping in 3D
journal, May 2010

  • Holm, Liisa; Rosenstr�m, P�ivi
  • Nucleic Acids Research, Vol. 38, Issue suppl_2
  • DOI: 10.1093/nar/gkq366

ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SB
journal, July 2015

  • Maier, James A.; Martinez, Carmenza; Kasavajhala, Koushik
  • Journal of Chemical Theory and Computation, Vol. 11, Issue 8
  • DOI: 10.1021/acs.jctc.5b00255

Structure Determination of an Immunopotentiator Peptide, Cinnamycin, Complexed with Lysophosphatidylethanolamine by 1H-NMR
journal, February 1996


A novel mechanism of immunity controls the onset of cinnamycin biosynthesis in Streptomyces cinnamoneus DSM 40646
journal, November 2016

  • O’Rourke, Sean; Widdick, David; Bibb, Mervyn
  • Journal of Industrial Microbiology & Biotechnology, Vol. 44, Issue 4-5
  • DOI: 10.1007/s10295-016-1869-9

Features and development of Coot
journal, March 2010

  • Emsley, P.; Lohkamp, B.; Scott, W. G.
  • Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 4
  • DOI: 10.1107/S0907444910007493

Atomic charges derived from semiempirical methods
journal, May 1990

  • Besler, Brent H.; Merz, Kenneth M.; Kollman, Peter A.
  • Journal of Computational Chemistry, Vol. 11, Issue 4
  • DOI: 10.1002/jcc.540110404

REFMAC 5 dictionary: organization of prior chemical knowledge and guidelines for its use
journal, November 2004

  • Vagin, Alexei A.; Steiner, Roberto A.; Lebedev, Andrey A.
  • Acta Crystallographica Section D Biological Crystallography, Vol. 60, Issue 12
  • DOI: 10.1107/S0907444904023510

REFMAC 5 for the refinement of macromolecular crystal structures
journal, March 2011

  • Murshudov, Garib N.; Skubák, Pavol; Lebedev, Andrey A.
  • Acta Crystallographica Section D Biological Crystallography, Vol. 67, Issue 4
  • DOI: 10.1107/S0907444911001314

The structure of PA48009: The revised structure of duramycin.
journal, January 1990


Towards automated crystallographic structure refinement with phenix.refine
journal, March 2012

  • Afonine, Pavel V.; Grosse-Kunstleve, Ralf W.; Echols, Nathaniel
  • Acta Crystallographica Section D Biological Crystallography, Vol. 68, Issue 4
  • DOI: 10.1107/S0907444912001308

Duramycins B and C, two new lanthionine containing antibiotics as inhibitors of phospholipase A2. Structural revision of duramycin and cinnamycin.
journal, January 1990

  • Fredenhagen, Andreas; Fendrich, Gabriele; MÄRki, Fritz
  • The Journal of Antibiotics, Vol. 43, Issue 11
  • DOI: 10.7164/antibiotics.43.1403

The Structure of the Polycyclic NonadecapeptideRo 09-0198
journal, December 1988

  • Kessler, Horst; Steuernagel, Stefan; Will, Martin
  • Helvetica Chimica Acta, Vol. 71, Issue 8
  • DOI: 10.1002/hlca.19880710811

Routine Microsecond Molecular Dynamics Simulations with AMBER on GPUs. 1. Generalized Born
journal, April 2012

  • Götz, Andreas W.; Williamson, Mark J.; Xu, Dong
  • Journal of Chemical Theory and Computation, Vol. 8, Issue 5
  • DOI: 10.1021/ct200909j

99mTc-Labeled Duramycin as a Novel Phosphatidylethanolamine-Binding Molecular Probe
journal, July 2008


Accessing chemical diversity from the uncultivated symbionts of small marine animals
journal, January 2018

  • Smith, Thomas E.; Pond, Christopher D.; Pierce, Elizabeth
  • Nature Chemical Biology, Vol. 14, Issue 2
  • DOI: 10.1038/nchembio.2537

Cloning and engineering of the cinnamycin biosynthetic gene cluster from Streptomyces cinnamoneus cinnamoneus DSM 40005
journal, March 2003

  • Widdick, D. A.; Dodd, H. M.; Barraille, P.
  • Proceedings of the National Academy of Sciences, Vol. 100, Issue 7
  • DOI: 10.1073/pnas.0230516100

Noninvasive Whole-Body Imaging of Phosphatidylethanolamine as a Cell Death Marker Using 99m Tc-Duramycin During TNF-Induced SIRS
journal, February 2018

  • Delvaeye, Tinneke; wyffels, Leonie; Deleye, Steven
  • Journal of Nuclear Medicine, Vol. 59, Issue 7
  • DOI: 10.2967/jnumed.117.205815

Isolation and structure determination of a new lantibiotic cinnamycin B from Actinomadura atramentaria based on genome mining
journal, June 2016

  • Kodani, Shinya; Komaki, Hisayuki; Ishimura, Sho
  • Journal of Industrial Microbiology & Biotechnology, Vol. 43, Issue 8
  • DOI: 10.1007/s10295-016-1788-9

electronic Ligand Builder and Optimization Workbench ( eLBOW ): a tool for ligand coordinate and restraint generation
journal, September 2009

  • Moriarty, Nigel W.; Grosse-Kunstleve, Ralf W.; Adams, Paul D.
  • Acta Crystallographica Section D Biological Crystallography, Vol. 65, Issue 10
  • DOI: 10.1107/S0907444909029436

Data processing and analysis with the autoPROC toolbox
journal, March 2011

  • Vonrhein, Clemens; Flensburg, Claus; Keller, Peter
  • Acta Crystallographica Section D Biological Crystallography, Vol. 67, Issue 4
  • DOI: 10.1107/S0907444911007773

Development and testing of a general amber force field
journal, January 2004

  • Wang, Junmei; Wolf, Romain M.; Caldwell, James W.
  • Journal of Computational Chemistry, Vol. 25, Issue 9
  • DOI: 10.1002/jcc.20035

Substrate control in stereoselective lanthionine biosynthesis
journal, November 2014

  • Tang, Weixin; Jiménez-Osés, Gonzalo; Houk, K. N.
  • Nature Chemistry, Vol. 7, Issue 1
  • DOI: 10.1038/nchem.2113

Enzymatic assembly of DNA molecules up to several hundred kilobases
journal, April 2009

  • Gibson, Daniel G.; Young, Lei; Chuang, Ray-Yuan
  • Nature Methods, Vol. 6, Issue 5, p. 343-345
  • DOI: 10.1038/nmeth.1318

A well-behaved electrostatic potential based method using charge restraints for deriving atomic charges: the RESP model
journal, October 1993

  • Bayly, Christopher I.; Cieplak, Piotr; Cornell, Wendy
  • The Journal of Physical Chemistry, Vol. 97, Issue 40
  • DOI: 10.1021/j100142a004

Streptomyces albus : A New Cell Factory for Non-Canonical Amino Acids Incorporation into Ribosomally Synthesized Natural Products
journal, August 2017

  • Lopatniuk, Mariia; Myronovskyi, Maksym; Luzhetskyy, Andriy
  • ACS Chemical Biology, Vol. 12, Issue 9
  • DOI: 10.1021/acschembio.7b00359

Phaser crystallographic software
journal, July 2007

  • McCoy, Airlie J.; Grosse-Kunstleve, Ralf W.; Adams, Paul D.
  • Journal of Applied Crystallography, Vol. 40, Issue 4
  • DOI: 10.1107/S0021889807021206

An Exact Correction to the “Cheng-Prusoff” Correction
journal, January 1988