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Title: Design of potent and highly selective inhibitors for human β-secretase 2 (memapsin 1), a target for type 2 diabetes

Abstract

Structure-based design and syntheses of potent and highly selective BACE2 inhibitors are described.

Authors:
 [1];  [1];  [2];  [1];  [1];  [3];  [3];  [3];  [4]
  1. Department of Chemistry and Department of Medicinal Chemistry; Purdue University; West Lafayette; USA
  2. Department of Biological Sciences; Purdue University; West Lafayette; USA
  3. Protein Studies Program; Oklahoma Medical Research Foundation; University of Oklahoma; Oklahoma City; USA
  4. Department of Chemistry and Department of Medicinal Chemistry; Purdue University; West Lafayette; USA; Department of Biological Sciences
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Org.:
UNIVERSITYNIH
OSTI Identifier:
1498398
Resource Type:
Journal Article
Journal Name:
Chemical Science
Additional Journal Information:
Journal Volume: 7; Journal Issue: 5; Journal ID: ISSN 2041-6520
Publisher:
Royal Society of Chemistry
Country of Publication:
United States
Language:
ENGLISH

Citation Formats

Ghosh, Arun K., Reddy, Bhavanam Sekhara, Yen, Yu-Chen, Cárdenas, Emilio L., Rao, Kalapala Venkateswara, Downs, Deborah, Huang, Xiangping, Tang, Jordan, and Mesecar, Andrew D. Design of potent and highly selective inhibitors for human β-secretase 2 (memapsin 1), a target for type 2 diabetes. United States: N. p., 2016. Web. doi:10.1039/C5SC03718B.
Ghosh, Arun K., Reddy, Bhavanam Sekhara, Yen, Yu-Chen, Cárdenas, Emilio L., Rao, Kalapala Venkateswara, Downs, Deborah, Huang, Xiangping, Tang, Jordan, & Mesecar, Andrew D. Design of potent and highly selective inhibitors for human β-secretase 2 (memapsin 1), a target for type 2 diabetes. United States. doi:10.1039/C5SC03718B.
Ghosh, Arun K., Reddy, Bhavanam Sekhara, Yen, Yu-Chen, Cárdenas, Emilio L., Rao, Kalapala Venkateswara, Downs, Deborah, Huang, Xiangping, Tang, Jordan, and Mesecar, Andrew D. Fri . "Design of potent and highly selective inhibitors for human β-secretase 2 (memapsin 1), a target for type 2 diabetes". United States. doi:10.1039/C5SC03718B.
@article{osti_1498398,
title = {Design of potent and highly selective inhibitors for human β-secretase 2 (memapsin 1), a target for type 2 diabetes},
author = {Ghosh, Arun K. and Reddy, Bhavanam Sekhara and Yen, Yu-Chen and Cárdenas, Emilio L. and Rao, Kalapala Venkateswara and Downs, Deborah and Huang, Xiangping and Tang, Jordan and Mesecar, Andrew D.},
abstractNote = {Structure-based design and syntheses of potent and highly selective BACE2 inhibitors are described.},
doi = {10.1039/C5SC03718B},
journal = {Chemical Science},
issn = {2041-6520},
number = 5,
volume = 7,
place = {United States},
year = {2016},
month = {1}
}

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