The binding of DCC-P3 motif and FAK-FAT domain mediates the initial step of netrin-1/DCC signaling for axon attraction

Xu, Shutong; Liu, Yiqiong; Li, Xiaolong; Liu, Ying; Meijers, Rob; Zhang, Yan; Wang, Jia-huai

doi:10.1038/s41421-017-0008-8

Title: The binding of DCC-P3 motif and FAK-FAT domain mediates the initial step of netrin-1/DCC signaling for axon attraction

Journal Article · Tue Feb 20 00:00:00 EST 2018 · Cell Discovery

DOI:https://doi.org/10.1038/s41421-017-0008-8· OSTI ID:1498365

Xu, Shutong; Liu, Yiqiong; Li, Xiaolong; Liu, Ying; Meijers, Rob; Zhang, Yan; Wang, Jia-huai

Cite

Export

Save

Research Organization:: Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Organization:: National Institutes of Health (NIH)

OSTI ID:: 1498365

Journal Information:: Cell Discovery, Vol. 4, Issue 1; ISSN 2056-5968

Country of Publication:: United States

Language:: ENGLISH

References (45)

The Down Syndrome Cell Adhesion Molecule (DSCAM) Interacts with and Activates Pak Li, Weiquan; Guan, Kun-Liang Journal of Biological Chemistry, Vol. 279, Issue 31 https://doi.org/10.1074/jbc.M401878200	journal	May 2004
Netrins: beyond the brain Cirulli, Vincenzo; Yebra, Mayra Nature Reviews Molecular Cell Biology, Vol. 8, Issue 4 https://doi.org/10.1038/nrm2142	journal	March 2007
Activation of FAK and Src are receptor-proximal events required for netrin signaling Li, Weiquan; Lee, Jeeyong; Vikis, Haris G. Nature Neuroscience, Vol. 7, Issue 11 https://doi.org/10.1038/nn1329	journal	October 2004
Cargo recognition mechanism of myosin X revealed by the structure of its tail MyTH4-FERM tandem in complex with the DCC P3 domain Wei, Zhiyi; Yan, Jing; Lu, Qing Proceedings of the National Academy of Sciences, Vol. 108, Issue 9 https://doi.org/10.1073/pnas.1016567108	journal	February 2011
frazzled Encodes a Drosophila Member of the DCC Immunoglobulin Subfamily and Is Required for CNS and Motor Axon Guidance Kolodziej, Peter A.; Timpe, Leslie C.; Mitchell, Kevin J. Cell, Vol. 87, Issue 2 https://doi.org/10.1016/S0092-8674(00)81338-0	journal	October 1996
Less than 5 Netrin-1 molecules initiate attraction but 200 Sema3A molecules are necessary for repulsion Pinato, Giulietta; Cojoc, Dan; Lien, Linh Thuy Scientific Reports, Vol. 2, Issue 1 https://doi.org/10.1038/srep00675	journal	September 2012
Refinement of Macromolecular Structures by the Maximum-Likelihood Method Murshudov, G. N.; Vagin, A. A.; Dodson, E. J. Acta Crystallographica Section D Biological Crystallography, Vol. 53, Issue 3 https://doi.org/10.1107/S0907444996012255	journal	May 1997
Pattern of invasion of the embryonic mouse spinal cord by microglial cells at the time of the onset of functional neuronal networks Rigato, C.; Buckinx, R.; Le-Corronc, H. Glia, Vol. 59, Issue 4 https://doi.org/10.1002/glia.21140	journal	February 2011
Structural Basis for the Interaction between Pyk2-FAT Domain and Leupaxin LD Repeats Vanarotti, Murugendra S.; Finkelstein, David B.; Guibao, Cristina D. Biochemistry, Vol. 55, Issue 9 https://doi.org/10.1021/acs.biochem.5b01274	journal	February 2016
A Ligand-Gated Association between Cytoplasmic Domains of UNC5 and DCC Family Receptors Converts Netrin-Induced Growth Cone Attraction to Repulsion Hong, Kyonsoo; Hinck, Lindsay; Nishiyama, Makoto Cell, Vol. 97, Issue 7 https://doi.org/10.1016/S0092-8674(00)80804-1	journal	June 1999
Calcium signalling in the guidance of nerve growth by netrin-1 Hong, Kyonsoo; Nishiyama, Makoto; Henley, John Nature, Vol. 403, Issue 6765 https://doi.org/10.1038/47507	journal	January 2000
The axonal chemoattractant netrin-1 is also a chemorepellent for trochlear motor axons Colamarino, Sophia A.; Tessier-Lavigne, Marc Cell, Vol. 81, Issue 4 https://doi.org/10.1016/0092-8674(95)90083-7	journal	May 1995
The focal adhesion targeting (FAT) region of focal adhesion kinase is a four-helix bundle that binds paxillin Hayashi, Ikuko; Vuori, Kristiina; Liddington, Robert C. Nature Structural Biology, Vol. 9, Issue 2 https://doi.org/10.1038/nsb755	journal	January 2002
Paxillin comes of age Deakin, N. O.; Turner, C. E. Journal of Cell Science, Vol. 121, Issue 15 https://doi.org/10.1242/jcs.018044	journal	August 2008
MolProbity : all-atom structure validation for macromolecular crystallography Chen, Vincent B.; Arendall, W. Bryan; Headd, Jeffrey J. Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 1 https://doi.org/10.1107/S0907444909042073	journal	December 2009
Detection of a hidden folding intermediate in the focal adhesion target domain: Implications for its function and folding Zhou, Zheng; Feng, Hanqiao; Bai, Yawen Proteins: Structure, Function, and Bioinformatics, Vol. 65, Issue 2 https://doi.org/10.1002/prot.21107	journal	August 2006
Coot model-building tools for molecular graphics Emsley, Paul; Cowtan, Kevin Acta Crystallographica Section D Biological Crystallography, Vol. 60, Issue 12, p. 2126-2132 https://doi.org/10.1107/S0907444904019158	journal	November 2004
Binding of DCC by Netrin-1 to Mediate Axon Guidance Independent of Adenosine A2B Receptor Activation Stein, E. Science, Vol. 291, Issue 5510 https://doi.org/10.1126/science.1059391	journal	March 2001
Molecular Recognition of Paxillin LD Motifs by the Focal Adhesion Targeting Domain Hoellerer, Maria K.; Noble, Martin E. M.; Labesse, Gilles Structure, Vol. 11, Issue 10 https://doi.org/10.1016/j.str.2003.08.010	journal	October 2003
Signaling mechanism of the netrin-1 receptor DCC in axon guidance Finci, L.; Zhang, Y.; Meijers, R. Progress in Biophysics and Molecular Biology, Vol. 118, Issue 3 https://doi.org/10.1016/j.pbiomolbio.2015.04.001	journal	September 2015
Focal adhesion kinase: in command and control of cell motility Mitra, Satyajit K.; Hanson, Daniel A.; Schlaepfer, David D. Nature Reviews Molecular Cell Biology, Vol. 6, Issue 1 https://doi.org/10.1038/nrm1549	journal	January 2005
The Role of Focal Adhesion Kinase Binding in the Regulation of Tyrosine Phosphorylation of Paxillin Thomas, Jeffrey W.; Cooley, Marion A.; Broome, Jill M. Journal of Biological Chemistry, Vol. 274, Issue 51 https://doi.org/10.1074/jbc.274.51.36684	journal	December 1999
Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord Kennedy, Timothy E.; Serafini, Tito; de la Torre, JoséR. Cell, Vol. 78, Issue 3 https://doi.org/10.1016/0092-8674(94)90421-9	journal	August 1994
Structural Basis for the Autoinhibition of Focal Adhesion Kinase Lietha, Daniel; Cai, Xinming; Ceccarelli, Derek F. J. Cell, Vol. 129, Issue 6 https://doi.org/10.1016/j.cell.2007.05.041	journal	June 2007
PHENIX: a comprehensive Python-based system for macromolecular structure solution Adams, Paul D.; Afonine, Pavel V.; Bunkóczi, Gábor Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 2, p. 213-221 https://doi.org/10.1107/S0907444909052925	journal	January 2010
The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6 Serafini, Tito; Kennedy, Timothy E.; Gaiko, Michael J. Cell, Vol. 78, Issue 3 https://doi.org/10.1016/0092-8674(94)90420-0	journal	August 1994
Requirement of TRPC channels in netrin-1-induced chemotropic turning of nerve growth cones Wang, Gordon X.; Poo, Mu-ming Nature, Vol. 434, Issue 7035 https://doi.org/10.1038/nature03478	journal	March 2005
Calcium Ion Coordination: A Comparison with That of Beryllium, Magnesium, and Zinc Katz, Amy Kaufman; Glusker, Jenny P.; Beebe, Scott A. Journal of the American Chemical Society, Vol. 118, Issue 24 https://doi.org/10.1021/ja953943i	journal	January 1996
Axon guidance molecules Keynes, Roger; Cook, Geoffrey M. W. Cell, Vol. 83, Issue 2 https://doi.org/10.1016/0092-8674(95)90157-4	journal	October 1995
Structures of netrin-1 bound to two receptors provide insight into its axon guidance mechanism Xu, K.; Wu, Z.; Renier, N. Science, Vol. 344, Issue 6189 https://doi.org/10.1126/science.1255149	journal	May 2014
Crystal structures of free and ligand-bound focal adhesion targeting domain of Pyk2 Lulo, James; Yuzawa, Satoru; Schlessinger, Joseph Biochemical and Biophysical Research Communications, Vol. 383, Issue 3 https://doi.org/10.1016/j.bbrc.2009.04.011	journal	June 2009
Neogenin, an avian cell surface protein expressed during terminal neuronal differentiation, is closely related to the human tumor suppressor molecule deleted in colorectal cancer Vielmetter, J. The Journal of Cell Biology, Vol. 127, Issue 6 https://doi.org/10.1083/jcb.127.6.2009	journal	December 1994
Phosphatidylinositol 4,5-bisphosphate triggers activation of focal adhesion kinase by inducing clustering and conformational changes Goni, G. M.; Epifano, C.; Boskovic, J. Proceedings of the National Academy of Sciences, Vol. 111, Issue 31 https://doi.org/10.1073/pnas.1317022111	journal	July 2014
Conformational Dynamics of the Focal Adhesion Targeting Domain Control Specific Functions of Focal Adhesion Kinase in Cells Kadaré, Gress; Gervasi, Nicolas; Brami-Cherrier, Karen Journal of Biological Chemistry, Vol. 290, Issue 1 https://doi.org/10.1074/jbc.M114.593632	journal	November 2014
The Molecular Biology of Axon Guidance Tessier-Lavigne, M.; Goodman, C. S. Science, Vol. 274, Issue 5290 https://doi.org/10.1126/science.274.5290.1123	journal	November 1996
Focal adhesion kinase in netrin-1 signaling Ren, Xiu-rong; Ming, Guo-li; Xie, Yi Nature Neuroscience, Vol. 7, Issue 11 https://doi.org/10.1038/nn1330	journal	October 2004
Focal adhesion kinase: the first ten years Parsons, J. T. Journal of Cell Science, Vol. 116, Issue 8 https://doi.org/10.1242/jcs.00373	journal	April 2003
The Structural Basis of Localization and Signaling by the Focal Adhesion Targeting Domain Arold, Stefan T.; Hoellerer, Maria K.; Noble, Martin E. M. Structure, Vol. 10, Issue 3 https://doi.org/10.1016/S0969-2126(02)00717-7	journal	March 2002
Paxillin LD motifs may define a new family of protein recognition domains Brown, Michael C.; Curtis, Michael S.; Turner, Christopher E. Nature Structural & Molecular Biology, Vol. 5, Issue 8 https://doi.org/10.1038/1370	journal	August 1998
How focal adhesion kinase achieves regulation by linking ligand binding, localization and action Arold, Stefan T. Current Opinion in Structural Biology, Vol. 21, Issue 6 https://doi.org/10.1016/j.sbi.2011.09.008	journal	December 2011
[20] Processing of X-ray diffraction data collected in oscillation mode Otwinowski, Zbyszek; Minor, Wladek Macromolecular Crystallography Part A, 307-326 https://doi.org/10.1016/S0076-6879(97)76066-X	book	January 1997
Spatial organization of transmembrane receptor signalling Bethani, Ioanna; Skånland, Sigrid S.; Dikic, Ivan The EMBO Journal, Vol. 29, Issue 16 https://doi.org/10.1038/emboj.2010.175	journal	August 2010
Deleted in Colorectal Cancer (DCC) Encodes a Netrin Receptor Keino-Masu, Kazuko; Masu, Masayuki; Hinck, Lindsay Cell, Vol. 87, Issue 2 https://doi.org/10.1016/S0092-8674(00)81336-7	journal	October 1996
Structural Decoding of the Netrin-1/UNC5 Interaction and its Therapeutical Implications in Cancers Grandin, Mélodie; Meier, Markus; Delcros, Jean Guy Cancer Cell, Vol. 29, Issue 2 https://doi.org/10.1016/j.ccell.2016.01.001	journal	February 2016
The Crystal Structure of Netrin-1 in Complex with DCC Reveals the Bifunctionality of Netrin-1 As a Guidance Cue Finci, Lorenzo I.; Krüger, Nina; Sun, Xiaqin Neuron, Vol. 83, Issue 4 https://doi.org/10.1016/j.neuron.2014.07.010	journal	August 2014

Similar Records

Tumor suppressor, AT motif binding factor 1 (ATBF1), translocates to the nucleus with runt domain transcription factor 3 (RUNX3) in response to TGF-{beta} signal transduction

Journal Article · Fri Jul 23 00:00:00 EDT 2010 · Biochemical and Biophysical Research Communications · OSTI ID:1498365

Mabuchi, Motoshi; Kataoka, Hiromi; Miura, Yutaka; +13 more

Netrin-1 induces the migration of Schwann cells via p38 MAPK and PI3K-Akt signaling pathway mediated by the UNC5B receptor

Journal Article · Fri Aug 14 00:00:00 EDT 2015 · Biochemical and Biophysical Research Communications · OSTI ID:1498365

Lv, Jianwei; Sun, Xiaolei; Ma, Jianxiong; +5 more

STRUCTURE OF THE LA MOTIF: A WINGED HELIX DOMAIN MEDIATES RNA BINDING VIA A CONSERVED AROMATIC PATCH

Journal Article · Thu Jan 01 00:00:00 EST 2004 · J. MOL. BIOL. · OSTI ID:1498365

DONG, G; CHAKSHUSMATHI, G; WOLIN, S; +1 more

Title: The binding of DCC-P3 motif and FAK-FAT domain mediates the initial step of netrin-1/DCC signaling for axon attraction

Citation Formats

References (45)

Similar Records

Related Subjects