Structural basis for substrate recognition and inhibition of prephenate aminotransferase from Arabidopsis

doi:10.1111/tpj.13856

Title: Structural basis for substrate recognition and inhibition of prephenate aminotransferase from Arabidopsis

Authors:

Holland, Cynthia K. ^[1]; Berkovich, Daniel A. ^[1]; Kohn, Madeleine L. ^[1]; Maeda, Hiroshi ^[2]; Jez, Joseph M. ^[1]

Department of Biology, Washington University in St Louis, St Louis MO 63130 USA
Department of Botany, University of Wisconsin-Madison, Madison WI 53706 USA

Publication Date:: 2018-03-14

Research Org.:: Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Org.:: National Science Foundation (NSF)

OSTI Identifier:: 1498336

Resource Type:: Journal Article

Journal Name:: The Plant Journal

Additional Journal Information:: Journal Volume: 94; Journal Issue: 2; Journal ID: ISSN 0960-7412

Publisher:: Society for Experimental Biology

Country of Publication:: United States

Language:: ENGLISH

Citation Formats


                    Holland, Cynthia K., Berkovich, Daniel A., Kohn, Madeleine L., Maeda, Hiroshi, and Jez, Joseph M. Structural basis for substrate recognition and inhibition of prephenate aminotransferase from Arabidopsis.  United States: N. p., 2018. 
        Web.  doi:10.1111/tpj.13856.

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                    Holland, Cynthia K., Berkovich, Daniel A., Kohn, Madeleine L., Maeda, Hiroshi, & Jez, Joseph M. Structural basis for substrate recognition and inhibition of prephenate aminotransferase from Arabidopsis.  United States.  doi:10.1111/tpj.13856.

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                    Holland, Cynthia K., Berkovich, Daniel A., Kohn, Madeleine L., Maeda, Hiroshi, and Jez, Joseph M. Wed .  
        "Structural basis for substrate recognition and inhibition of prephenate aminotransferase from Arabidopsis".  United States.  doi:10.1111/tpj.13856.

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@article{osti_1498336,

  title        = {Structural basis for substrate recognition and inhibition of prephenate aminotransferase from Arabidopsis},

  author       = {Holland, Cynthia K. and Berkovich, Daniel A. and Kohn, Madeleine L. and Maeda, Hiroshi and Jez, Joseph M.},

  abstractNote = {},

  doi          = {10.1111/tpj.13856},

  journal      = {The Plant Journal},

  issn         = {0960-7412},

  number       = 2,

  volume       = 94,

  place        = {United States},

  year         = {2018},

  month        = {3}

}

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Journal Article:

DOI: 10.1111/tpj.13856

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Title: Structural basis for substrate recognition and inhibition of prephenate aminotransferase from Arabidopsis

Citation Formats

Lignin Biosynthesis journal, June 2003

Auxin Biosynthesis: A Simple Two-Step Pathway Converts Tryptophan to Indole-3-Acetic Acid in Plants journal, March 2012

Aspartate aminotransferase with the pyridoxal-5'-phosphate-binding lysine residue replaced by histidine retains partial catalytic competence journal, January 1990

Enzymology of l-Tyrosine Biosynthesis in Mung Bean ( Vigna radiata [L.] Wilczek) journal, November 1979

Tissue Distribution and Subcellular Localization of Prephenate Aminotransferase in Leaves of Sorghum bicolor journal, June 1986

The Shikimate Pathway and Aromatic Amino Acid Biosynthesis in Plants journal, June 2012

RNAi Suppression of Arogenate Dehydratase1 Reveals That Phenylalanine Is Synthesized Predominantly via the Arogenate Pathway in Petunia Petals journal, March 2010

Deciphering the Role of Aspartate and Prephenate Aminotransferase Activities in Plastid Nitrogen Metabolism journal, December 2013

Interaction of the herbicide glyphosate with its target enzyme 5-enolpyruvylshikimate 3-phosphate synthase in atomic detail journal, February 2001

Identification, characterization and comparative analysis of a novel chorismate mutase gene in Arabidopsis thaliana journal, November 1999

Novel regulatory mechanism of serine biosynthesis associated with 3-phosphoglycerate dehydrogenase in Arabidopsis thaliana journal, June 2017

Identification of a plant gene encoding glutamate/aspartate-prephenate aminotransferase: The last homeless enzyme of aromatic amino acids biosynthesis journal, September 2010

Phylobiochemical Characterization of Class-Ib Aspartate/Prephenate Aminotransferases Reveals Evolution of the Plant Arogenate Phenylalanine Pathway journal, July 2014

Benzylisoquinoline Alkaloid Metabolism: A Century of Discovery and a Brave New World journal, March 2013

The Shikimate Pathway — A Metabolic Tree with Many Branche journal, January 1990

Cytosolic and plastidic chorismate mutase isozymes from Arabidopsis thaliana: molecular characterization and enzymatic properties journal, November 1996

Mechanism of action of aspartate aminotransferase proposed on the basis of its spatial structure journal, April 1984

Crystal structure of true enzymic reaction intermediates: Aspartate and glutamate ketimines in aspartate aminotransferase journal, December 1993

Characterization of aromatic aminotransferases from Ephedra sinica Stapf journal, February 2016

New Insights into the Shikimate and Aromatic Amino Acids Biosynthesis Pathways in Plants journal, November 2010

A petunia chorismate mutase specialized for the production of floral volatiles journal, January 2010

Shikimate and Phenylalanine Biosynthesis in the Green Lineage journal, January 2013

Structure of Thermus thermophilus HB8 Aspartate Aminotransferase and Its Complex with Maleate † , ‡ journal, February 1999

Chloroplasts of higher plants synthesize L-phenylalanine via L-arogenate. journal, October 1986

Detection of a gem-diamine and a stable quinonoid intermediate in the reaction catalyzed by serine–glyoxylate aminotransferase from Hyphomicrobium methylovorum journal, June 2009

Enhancing Vitamin E in Oilseeds: Unraveling Tocopherol and Tocotrienol Biosynthesis journal, February 2007

Tyrosine and Phenylalanine Are Synthesized within the Plastids in Arabidopsis journal, January 2009

Aspartate aminotransferase: An old dog teaches new tricks journal, February 2014

Arogenate Dehydratase Isoenzymes Profoundly and Differentially Modulate Carbon Flux into Lignins journal, February 2012

14-3-3 Proteins fine-tune plant nutrient metabolism journal, November 2010

Mechanism of Control of Arabidopsis thaliana Aspartate Kinase-Homoserine Dehydrogenase by Threonine journal, November 2002

HKL -3000: the integration of data reduction and structure solution – from diffraction images to an initial model in minutes journal, July 2006

Structural Evolution of Differential Amino Acid Effector Regulation in Plant Chorismate Mutases journal, August 2014

Coot model-building tools for molecular graphics journal, November 2004

Substrate Recognition Mechanism of Thermophilic Dual-Substrate Enzyme journal, July 2001

Novel features of prephenate aminotransferase from cell cultures of Nicotiana silvestris journal, April 1985

Stress-Induced Phenylpropanoid Metabolism. journal, July 1995

PHENIX: a comprehensive Python-based system for macromolecular structure solution journal, January 2010

Cyanogenic Glycosides: Synthesis, Physiology, and Phenotypic Plasticity journal, April 2014

Nature’s assembly line: biosynthesis of simple phenylpropanoids and polyketides journal, May 2008

Designing a coupled assay system for aspartate aminotransferase journal, January 1995

Genetic and molecular identification of genes required for female gametophyte development and function in Arabidopsis journal, January 2005

Phenylalanine Biosynthesis in Arabidopsis thaliana : IDENTIFICATION AND CHARACTERIZATION OF AROGENATE DEHYDRATASES journal, August 2007

Potent Inhibitors of a Shikimate Pathway Enzyme from Mycobacterium tuberculosis : COMBINING MECHANISM- AND MODELING-BASED DESIGN journal, March 2011

Chorismate mutase in microorganisms and plants journal, November 1995

Identification of Six Novel Allosteric Effectors of Arabidopsis thaliana Aspartate Kinase-Homoserine Dehydrogenase Isoforms : PHYSIOLOGICAL CONTEXT SETS THE SPECIFICITY journal, October 2005

The Novel Substrate Recognition Mechanism Utilized by Aspartate Aminotransferase of the Extreme Thermophile Thermus thermophilus HB8 journal, November 1998

Mechanism of cysteine-dependent inactivation of aspartate/glutamate/cysteine sulfinic acid α-decarboxylases journal, June 2012

Prephenate aminotransferase directs plant phenylalanine biosynthesis via arogenate journal, November 2010

Phaser crystallographic software journal, July 2007

Lignin Biosynthesis
journal, June 2003

Auxin Biosynthesis: A Simple Two-Step Pathway Converts Tryptophan to Indole-3-Acetic Acid in Plants
journal, March 2012

Aspartate aminotransferase with the pyridoxal-5'-phosphate-binding lysine residue replaced by histidine retains partial catalytic competence
journal, January 1990

Enzymology of l-Tyrosine Biosynthesis in Mung Bean ( Vigna radiata [L.] Wilczek)
journal, November 1979

Tissue Distribution and Subcellular Localization of Prephenate Aminotransferase in Leaves of Sorghum bicolor
journal, June 1986

The Shikimate Pathway and Aromatic Amino Acid Biosynthesis in Plants
journal, June 2012

RNAi Suppression of Arogenate Dehydratase1 Reveals That Phenylalanine Is Synthesized Predominantly via the Arogenate Pathway in Petunia Petals
journal, March 2010

Deciphering the Role of Aspartate and Prephenate Aminotransferase Activities in Plastid Nitrogen Metabolism
journal, December 2013

Interaction of the herbicide glyphosate with its target enzyme 5-enolpyruvylshikimate 3-phosphate synthase in atomic detail
journal, February 2001

Identification, characterization and comparative analysis of a novel chorismate mutase gene in Arabidopsis thaliana
journal, November 1999

Novel regulatory mechanism of serine biosynthesis associated with 3-phosphoglycerate dehydrogenase in Arabidopsis thaliana
journal, June 2017

Identification of a plant gene encoding glutamate/aspartate-prephenate aminotransferase: The last homeless enzyme of aromatic amino acids biosynthesis
journal, September 2010

Phylobiochemical Characterization of Class-Ib Aspartate/Prephenate Aminotransferases Reveals Evolution of the Plant Arogenate Phenylalanine Pathway
journal, July 2014

Benzylisoquinoline Alkaloid Metabolism: A Century of Discovery and a Brave New World
journal, March 2013

The Shikimate Pathway — A Metabolic Tree with Many Branche
journal, January 1990

Cytosolic and plastidic chorismate mutase isozymes from Arabidopsis thaliana: molecular characterization and enzymatic properties
journal, November 1996

Mechanism of action of aspartate aminotransferase proposed on the basis of its spatial structure
journal, April 1984

Crystal structure of true enzymic reaction intermediates: Aspartate and glutamate ketimines in aspartate aminotransferase
journal, December 1993

Characterization of aromatic aminotransferases from Ephedra sinica Stapf
journal, February 2016

New Insights into the Shikimate and Aromatic Amino Acids Biosynthesis Pathways in Plants
journal, November 2010

A petunia chorismate mutase specialized for the production of floral volatiles
journal, January 2010

Shikimate and Phenylalanine Biosynthesis in the Green Lineage
journal, January 2013

Structure of Thermus thermophilus HB8 Aspartate Aminotransferase and Its Complex with Maleate ^† ^, ^‡
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Stress-Induced Phenylpropanoid Metabolism.
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PHENIX: a comprehensive Python-based system for macromolecular structure solution
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Cyanogenic Glycosides: Synthesis, Physiology, and Phenotypic Plasticity
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Genetic and molecular identification of genes required for female gametophyte development and function in Arabidopsis
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Potent Inhibitors of a Shikimate Pathway Enzyme from Mycobacterium tuberculosis : COMBINING MECHANISM- AND MODELING-BASED DESIGN
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The Novel Substrate Recognition Mechanism Utilized by Aspartate Aminotransferase of the Extreme Thermophile Thermus thermophilus HB8
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Mechanism of cysteine-dependent inactivation of aspartate/glutamate/cysteine sulfinic acid α-decarboxylases
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Prephenate aminotransferase directs plant phenylalanine biosynthesis via arogenate
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Phaser crystallographic software
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