Biological Evaluation and X-ray Co-crystal Structures of Cyclohexylpyrrolidine Ligands for Trypanothione Reductase, an Enzyme from the Redox Metabolism of Trypanosoma

doi:10.1002/cmdc.201800067

Title: Biological Evaluation and X-ray Co-crystal Structures of Cyclohexylpyrrolidine Ligands for Trypanothione Reductase, an Enzyme from the Redox Metabolism of Trypanosoma

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Authors:

De Gasparo, Raoul ^[1]; Brodbeck-Persch, Elke ^[1]; Bryson, Steve ^[2]; Hentzen, Nina B. ^[1]; Kaiser, Marcel ^[3];

^[2]; Krauth-Siegel, R. Luise ^[4];

^[1]

Laboratorium für Organische Chemie, ETH Zürich, Vladimir-Prelog-Weg 3 8093 Zürich Switzerland
Departments of Biochemistry, Medical Biophysics, and Molecular Genetics, University of Toronto, Medical Sciences Building, #5358, 1 King's College Circle Toronto ON M5S 1A8 Canada; The Campbell Family Institute for Cancer Research, University Health Network, 101 College Street Toronto ON M5G 1L7 Canada
Swiss Tropical and Public Health Institute, Socinstrasse 57 4002 Basel Switzerland; University of Basel, Petersplatz 1 4003 Basel Switzerland
Biochemie-Zentrum Heidelberg (BZH), Universität Heidelberg, Im Neuenheimer Feld 328 69120 Heidelberg Germany

Publication Date:: 2018-04-06

Research Org.:: Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Org.:: NCINIGMS

OSTI Identifier:: 1498318

Resource Type:: Journal Article

Journal Name:: ChemMedChem(Print)

Additional Journal Information:: Journal Volume: 13; Journal Issue: 9; Journal ID: ISSN 1860-7179

Publisher:: ChemPubSoc Europe

Country of Publication:: United States

Language:: ENGLISH

Citation Formats


                    De Gasparo, Raoul, Brodbeck-Persch, Elke, Bryson, Steve, Hentzen, Nina B., Kaiser, Marcel, Pai, Emil F., Krauth-Siegel, R. Luise, and Diederich, François. Biological Evaluation and X-ray Co-crystal Structures of Cyclohexylpyrrolidine Ligands for Trypanothione Reductase, an Enzyme from the Redox Metabolism of Trypanosoma.  United States: N. p., 2018. 
        Web.  doi:10.1002/cmdc.201800067.

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                    De Gasparo, Raoul, Brodbeck-Persch, Elke, Bryson, Steve, Hentzen, Nina B., Kaiser, Marcel, Pai, Emil F., Krauth-Siegel, R. Luise, & Diederich, François. Biological Evaluation and X-ray Co-crystal Structures of Cyclohexylpyrrolidine Ligands for Trypanothione Reductase, an Enzyme from the Redox Metabolism of Trypanosoma.  United States.  doi:10.1002/cmdc.201800067.

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                    De Gasparo, Raoul, Brodbeck-Persch, Elke, Bryson, Steve, Hentzen, Nina B., Kaiser, Marcel, Pai, Emil F., Krauth-Siegel, R. Luise, and Diederich, François. Fri .  
        "Biological Evaluation and X-ray Co-crystal Structures of Cyclohexylpyrrolidine Ligands for Trypanothione Reductase, an Enzyme from the Redox Metabolism of Trypanosoma".  United States.  doi:10.1002/cmdc.201800067.

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@article{osti_1498318,

  title        = {Biological Evaluation and X-ray Co-crystal Structures of Cyclohexylpyrrolidine Ligands for Trypanothione Reductase, an Enzyme from the Redox Metabolism of Trypanosoma},

  author       = {De Gasparo, Raoul and Brodbeck-Persch, Elke and Bryson, Steve and Hentzen, Nina B. and Kaiser, Marcel and Pai, Emil F. and Krauth-Siegel, R. Luise and Diederich, François},

  abstractNote = {},

  doi          = {10.1002/cmdc.201800067},

  journal      = {ChemMedChem(Print)},

  issn         = {1860-7179},

  number       = 9,

  volume       = 13,

  place        = {United States},

  year         = {2018},

  month        = {4}

}

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DOI: 10.1002/cmdc.201800067

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