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Title: Structural Basis for Receptor Activity-Modifying Protein-Dependent Selective Peptide Recognition by a G Protein-Coupled Receptor

Journal Article · · Molecular Cell
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Research Organization:
Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
NIHFOREIGN
OSTI ID:
1497150
Journal Information:
Molecular Cell, Vol. 58, Issue 6; ISSN 1097-2765
Publisher:
Cell Press - Elsevier
Country of Publication:
United States
Language:
ENGLISH

References (47)

Structural insights into RAMP modification of secretin family G protein-coupled receptors: implications for drug development journal October 2011
Mapping interaction sites within the N-terminus of the calcitonin gene-related peptide receptor; the role of residues 23–60 of the calcitonin receptor-like receptor journal January 2010
Receptor-activity-modifying proteins are required for forward trafficking of the calcium-sensing receptor to the plasma membrane journal October 2005
Solution structure of human calcitonin gene-related peptide by proton NMR and distance geometry with restrained molecular dynamics journal January 1991
Turn Structures in CGRP C-Terminal Analogues Promote Stable Arrangements of Key Residue Side Chains journal July 2001
Multiple Amylin Receptors Arise from Receptor Activity-Modifying Protein Interaction with the Calcitonin Receptor Gene Product journal July 1999
Calcitonin Gene-Related Peptide (CGRP) Receptor Antagonists in the Treatment of Migraine journal January 2010
Pramlintide in the Treatment of Diabetes Mellitus journal January 2008
Features and development of Coot journal March 2010
Determinants of 1-Piperidinecarboxamide, N -[2-[[5-Amino- l -[[4-(4-pyridinyl)- l -piperazinyl]carbonyl]pentyl]amino]-1-[(3,5-dibromo-4-hydroxyphenyl)methyl]-2-oxoethyl]-4-(1,4-dihydro-2-oxo-3(2 H )-quinazolinyl) (BIBN4096BS) Affinity for Calcitonin Gene-Related Peptide and Amylin Receptors—The Role of Receptor Activity Modifying Protein 1 journal September 2006
Bacterial expression and purification of a heterodimeric adrenomedullin receptor extracellular domain complex using DsbC-assisted disulfide shuffling journal March 2013
The pharmacology of Adrenomedullin 2/Intermedin: Adrenomedullin 2/intermedin pharmacology journal April 2012
Adrenomedullin Function in Vascular Endothelial Cells: Insights from Genetic Mouse Models journal December 2011
Crystal Structure of the PAC1R Extracellular Domain Unifies a Consensus Fold for Hormone Recognition by Class B G-Protein Coupled Receptors journal May 2011
Structural basis for extracellular interactions between calcitonin receptor-like receptor and receptor activity-modifying protein 2 for adrenomedullin-specific binding: Structural Basis of the Human AM-Receptor journal December 2011
Phaser crystallographic software journal July 2007
RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor journal May 1998
Selective CGRP and adrenomedullin peptide binding by tethered RAMP-calcitonin receptor-like receptor extracellular domain fusion proteins: Tethered RAMP-CLR Extracellular Domain Fusion Proteins journal October 2013
Mapping the CGRP receptor ligand binding domain: Tryptophan-84 of RAMP1 is critical for agonist and antagonist binding journal March 2010
Refinement of Macromolecular Structures by the Maximum-Likelihood Method journal May 1997
[20] Processing of X-ray diffraction data collected in oscillation mode book January 1997
RAMPs: the past, present and future journal November 2006
Crystal structure of the incretin-bound extracellular domain of a G protein-coupled receptor journal August 2007
Structure of micelle-bound adrenomedullin: A first step toward the analysis of its interactions with receptors and small molecules journal August 2011
Molecular recognition of parathyroid hormone by its G protein-coupled receptor journal March 2008
Structural Basis for Parathyroid Hormone-related Protein Binding to the Parathyroid Hormone Receptor and Design of Conformation-selective Peptides journal October 2009
Dimeric Arrangement of the Parathyroid Hormone Receptor and a Structural Mechanism for Ligand-induced Dissociation journal April 2010
International Union of Pharmacology. XXXII. The Mammalian Calcitonin Gene-Related Peptides, Adrenomedullin, Amylin, and Calcitonin Receptors journal June 2002
Molecular Pharmacology of the Calcitonin Receptor journal May 2002
Structure-function relationships of the N-terminus of receptor activity-modifying proteins: Receptor activity-modifying proteins journal December 2009
Identification of N-Terminal Receptor Activity-Modifying Protein Residues Important for Calcitonin Gene-Related Peptide, Adrenomedullin, and Amylin Receptor Function journal July 2008
Structure–function analysis of amino acid 74 of human RAMP1 and RAMP3 and its role in peptide interactions with adrenomedullin and calcitonin gene-related peptide receptors journal May 2011
From Micromolar to Nanomolar Affinity:  A Systematic Approach To Identify the Binding Site of CGRP at the Human Calcitonin Gene-Related Peptide 1 Receptor † journal January 1998
Crystal Structure of the Ligand-bound Glucagon-like Peptide-1 Receptor Extracellular Domain journal February 2008
Crystal Structure of the Ectodomain Complex of the CGRP Receptor, a Class-B GPCR, Reveals the Site of Drug Antagonism journal September 2010
Crystal Structure of Glucagon-like Peptide-1 in Complex with the Extracellular Domain of the Glucagon-like Peptide-1 Receptor* journal January 2010
Identification of key residues involved in adrenomedullin binding to the AM 1 receptor : Key residues for adrenomedullin binding journal April 2013
Structure-activity relationships for α-calcitonin gene-related peptide: CGRP structure-activity relationship journal November 2013
Receptor activity‐modifying protein‐dependent effects of mutations in the calcitonin receptor‐like receptor: implications for adrenomedullin and calcitonin gene‐related peptide pharmacology journal January 2014
Overview of the CCP 4 suite and current developments journal March 2011
Receptor Activity Modifying Proteins and Their Potential as Drug Targets book August 2010
RAMP-ing up Class-B GPCR ECD Structural Coverage journal September 2010
Mechanisms of peptide and nonpeptide ligand binding to Class B G-protein-coupled receptors journal March 2005
Structural Basis for Hormone Recognition by the Human CRFR2α G Protein-coupled Receptor journal December 2010
Functional Calcitonin Gene-related Peptide Receptors Are Formed by the Asymmetric Assembly of a Calcitonin Receptor-like Receptor Homo-oligomer and a Monomer of Receptor Activity-modifying Protein-1 journal October 2007
Molecular Recognition of Corticotropin-releasing Factor by Its G-protein-coupled Receptor CRFR1 journal November 2008
G-protein-coupled receptor 30 interacts with receptor activity-modifying protein 3 and confers sex-dependent cardioprotection journal May 2013

Cited By (26)

The Impact of Adrenomedullin Thr22 on Selectivity within the Calcitonin Receptor-like Receptor/Receptor Activity-Modifying Protein System journal July 2018
Adrenomedullin disulfide bond mimetics uncover structural requirements for AM 1 receptor activation journal January 2019
Multiplexed analysis of the secretin-like GPCR-RAMP interactome journal September 2019
Update on the pharmacology of calcitonin/CGRP family of peptides: IUPHAR Review 25: Pharmacology of the calcitonin/CGRP family journal November 2017
Molecular studies of CGRP and the CGRP family of peptides in the central nervous system journal March 2018
Crystal structures of MBP fusion proteins: Structures of MBP Fusion Proteins journal January 2016
Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor journal September 2018
Amylin: Pharmacology, Physiology, and Clinical Potential journal June 2015
Calcitonin and Amylin Receptor Peptide Interaction Mechanisms: INSIGHTS INTO PEPTIDE-BINDING MODES AND ALLOSTERIC MODULATION OF THE CALCITONIN RECEPTOR BY RECEPTOR ACTIVITY-MODIFYING PROTEINS journal February 2016
Calcitonin Gene‐Related Peptide Modulators – The History and Renaissance of a New Migraine Drug Class journal April 2019
CGRP receptor antagonist activity of olcegepant depends on the signalling pathway measured journal February 2017
Receptor activity-modifying proteins; multifunctional G protein-coupled receptor accessory proteins journal April 2016
Amylin structure-function relationships and receptor pharmacology: implications for amylin mimetic drug development: Amylin structure-function journal May 2016
Stachel -independent modulation of GPR56/ADGRG1 signaling by synthetic ligands directed to its extracellular region journal September 2017
CGRP and its receptors journal February 2017
A Molecular Dynamics Study of Vasoactive Intestinal Peptide Receptor 1 and the Basis of Its Therapeutic Antagonism journal September 2019
Type II Turn of Receptor-bound Salmon Calcitonin Revealed by X-ray Crystallography journal May 2016
Amylin journal May 2017
Multiplexed Analysis of the Secretin-like GPCR-RAMP Interactome journal April 2019
Amylin: Pharmacology, Physiology, and Clinical Potential text January 2015
Extracellular loops 2 and 3 of the calcitonin receptor selectively modify agonist binding and efficacy journal April 2018
An allosteric role for receptor activity-modifying proteins in defining GPCR pharmacology journal May 2016
Receptor activity-modifying protein-directed G protein signaling specificity for the calcitonin gene-related peptide family of receptors. journal December 2016
Modulation of Glucagon Receptor Pharmacology by Receptor Activity-modifying Protein-2 (RAMP2) journal September 2015
Loss of receptor activity-modifying protein 2 in mice causes placental dysfunction and alters PTH1R regulation text January 2017
GPCR Modulation of Thieno[2,3-b]pyridine Anti-Proliferative Agents journal December 2017

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