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Title: Chemical Rescue and Inhibition Studies to Determine the Role of Arg301 in Phosphite Dehydrogenase

Authors:
; ; ; ; ; ;
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Org.:
NSFHHMI
OSTI Identifier:
1497126
Resource Type:
Journal Article
Journal Name:
PLoS ONE
Additional Journal Information:
Journal Volume: 9; Journal Issue: 1; Journal ID: ISSN 1932-6203
Publisher:
Public Library of Science
Country of Publication:
United States
Language:
ENGLISH

Citation Formats

Hung, John E., Fogle, Emily J., Garg, Neha, Chekan, Jonathan R., Nair, Satish K., van der Donk, Wilfred A., and Vertessy, Beata G. Chemical Rescue and Inhibition Studies to Determine the Role of Arg301 in Phosphite Dehydrogenase. United States: N. p., 2014. Web. doi:10.1371/journal.pone.0087134.
Hung, John E., Fogle, Emily J., Garg, Neha, Chekan, Jonathan R., Nair, Satish K., van der Donk, Wilfred A., & Vertessy, Beata G. Chemical Rescue and Inhibition Studies to Determine the Role of Arg301 in Phosphite Dehydrogenase. United States. doi:10.1371/journal.pone.0087134.
Hung, John E., Fogle, Emily J., Garg, Neha, Chekan, Jonathan R., Nair, Satish K., van der Donk, Wilfred A., and Vertessy, Beata G. Fri . "Chemical Rescue and Inhibition Studies to Determine the Role of Arg301 in Phosphite Dehydrogenase". United States. doi:10.1371/journal.pone.0087134.
@article{osti_1497126,
title = {Chemical Rescue and Inhibition Studies to Determine the Role of Arg301 in Phosphite Dehydrogenase},
author = {Hung, John E. and Fogle, Emily J. and Garg, Neha and Chekan, Jonathan R. and Nair, Satish K. and van der Donk, Wilfred A. and Vertessy, Beata G.},
abstractNote = {},
doi = {10.1371/journal.pone.0087134},
journal = {PLoS ONE},
issn = {1932-6203},
number = 1,
volume = 9,
place = {United States},
year = {2014},
month = {1}
}

Works referenced in this record:

Is Arg418 the Catalytic Base Required for the Hydrolysis Step of the IMP Dehydrogenase Reaction?
journal, September 2005

  • Guillén Schlippe, Yollete V.; Hedstrom, Lizbeth
  • Biochemistry, Vol. 44, Issue 35
  • DOI: 10.1021/bi048342v

Guanidine Derivatives Rescue the Arg418Ala Mutation of Tritrichomonas foetus IMP Dehydrogenase
journal, December 2005

  • Guillén Schlippe, Yollete V.; Hedstrom, Lizbeth
  • Biochemistry, Vol. 44, Issue 50
  • DOI: 10.1021/bi051603w

Calculation of substrate dissociation constants from steady-state isotope effects in enzyme-catalyzed reactions
journal, February 1985

  • Klinman, Judith P.; Matthews, Rowena G.
  • Journal of the American Chemical Society, Vol. 107, Issue 4
  • DOI: 10.1021/ja00290a052

Blending Baeyer–Villiger monooxygenases: using a robust BVMO as a scaffold for creating chimeric enzymes with novel catalytic properties
journal, January 2012

  • van Beek, Hugo L.; Gonzalo, Gonzalo de; Fraaije, Marco W.
  • Chemical Communications, Vol. 48, Issue 27
  • DOI: 10.1039/c2cc17656d

Relaxing the Nicotinamide Cofactor Specificity of Phosphite Dehydrogenase by Rational Design
journal, October 2003

  • Woodyer, Ryan; van der Donk, Wilfred A.; Zhao, Huimin
  • Biochemistry, Vol. 42, Issue 40
  • DOI: 10.1021/bi035018b

Refinement of Macromolecular Structures by the Maximum-Likelihood Method
journal, May 1997

  • Murshudov, G. N.; Vagin, A. A.; Dodson, E. J.
  • Acta Crystallographica Section D Biological Crystallography, Vol. 53, Issue 3
  • DOI: 10.1107/S0907444996012255

High-level QM/MM modelling predicts an arginine as the acid in the condensation reaction catalysed by citrate synthase
journal, January 2008

  • van der Kamp, Marc W.; Perruccio, Francesca; Mulholland, Adrian J.
  • Chemical Communications, Issue 16
  • DOI: 10.1039/b800496j

Convergent evolution sheds light on the anti- -elimination mechanism common to family 1 and 10 polysaccharide lyases
journal, September 2002

  • Charnock, S. J.; Brown, I. E.; Turkenburg, J. P.
  • Proceedings of the National Academy of Sciences, Vol. 99, Issue 19
  • DOI: 10.1073/pnas.182431199

Structure of FAD-Bound l -Aspartate Oxidase:  Insight into Substrate Specificity and Catalysis ,
journal, March 2002

  • Bossi, Roberto T.; Negri, Armando; Tedeschi, Gabriella
  • Biochemistry, Vol. 41, Issue 9
  • DOI: 10.1021/bi015939r

Probing the Active Site of l -Aspartate Oxidase by Site-Directed Mutagenesis: Role of Basic Residues in Fumarate Reduction
journal, April 2001

  • Tedeschi, Gabriella; Ronchi, Severino; Simonic, Tatjana
  • Biochemistry, Vol. 40, Issue 15
  • DOI: 10.1021/bi002406u

On the Meaning of Km and V/K in Enzyme Kinetics
journal, September 1998

  • Northrop, Dexter B.
  • Journal of Chemical Education, Vol. 75, Issue 9
  • DOI: 10.1021/ed075p1153

An enzymatic fluorescent assay for the quantification of phosphite in a microtiter plate format
journal, May 2011

  • Berkowitz, Oliver; Jost, Ricarda; Pearse, Stuart J.
  • Analytical Biochemistry, Vol. 412, Issue 1
  • DOI: 10.1016/j.ab.2011.01.014

Directed Evolution of a Thermostable Phosphite Dehydrogenase for NAD(P)H Regeneration
journal, October 2005


Checking your imagination: applications of the free R value
journal, August 1996


Kinetic and Crystallographic Analysis of the Key Active Site Acid/Base Arginine in a Soluble Fumarate Reductase
journal, October 2001

  • Mowat, Christopher G.; Moysey, Ruth; Miles, Caroline S.
  • Biochemistry, Vol. 40, Issue 41
  • DOI: 10.1021/bi011360h

Phosphite utilization by the marine picocyanobacterium Prochlorococcus MIT9301: Phosphite utilization by Prochlorococcus MIT9301
journal, October 2011


Investigation of the Role of Arg301 Identified in the X-ray Structure of Phosphite Dehydrogenase
journal, May 2012

  • Hung, John E.; Fogle, Emily J.; Christman, Harry D.
  • Biochemistry, Vol. 51, Issue 21
  • DOI: 10.1021/bi201691w

PHENIX : building new software for automated crystallographic structure determination
journal, October 2002

  • Adams, Paul D.; Grosse-Kunstleve, Ralf W.; Hung, Li-Wei
  • Acta Crystallographica Section D Biological Crystallography, Vol. 58, Issue 11
  • DOI: 10.1107/S0907444902016657

Direct Bronsted analysis of the restoration of activity to a mutant enzyme by exogenous amines
journal, March 1989


Phosphite Dehydrogenase: A Versatile Cofactor-Regeneration Enzyme
journal, September 2002


Exploring the biocatalytic scope of a bacterial flavin-containing monooxygenase
journal, January 2011

  • Rioz-Martínez, Ana; Kopacz, Malgorzata; de Gonzalo, Gonzalo
  • Organic & Biomolecular Chemistry, Vol. 9, Issue 5
  • DOI: 10.1039/c0ob00988a

Pre-Steady-State Studies of Phosphite Dehydrogenase Demonstrate That Hydride Transfer Is Fully Rate Limiting
journal, November 2007

  • Fogle, Emily J.; van der Donk, Wilfred A.
  • Biochemistry, Vol. 46, Issue 45
  • DOI: 10.1021/bi701550c

Inhibition and pH Dependence of Phosphite Dehydrogenase
journal, May 2005

  • Relyea, Heather A.; Vrtis, Jennifer M.; Woodyer, Ryan
  • Biochemistry, Vol. 44, Issue 17
  • DOI: 10.1021/bi047640p

Site-Directed Mutagenesis of Active Site Residues of Phosphite Dehydrogenase
journal, March 2005

  • Woodyer, Ryan; Wheatley, Joshua L.; Relyea, Heather A.
  • Biochemistry, Vol. 44, Issue 12
  • DOI: 10.1021/bi047868c

Isolation and characterization of a soluble and thermostable phosphite dehydrogenase from Ralstonia sp. strain 4506
journal, April 2012

  • Hirota, Ryuichi; Yamane, Sho-taro; Fujibuchi, Tatsuya
  • Journal of Bioscience and Bioengineering, Vol. 113, Issue 4
  • DOI: 10.1016/j.jbiosc.2011.11.027

A twisted base? The role of arginine in enzyme-catalyzed proton abstractions
journal, January 2005

  • Guillén Schlippe, Yollete V.; Hedstrom, Lizbeth
  • Archives of Biochemistry and Biophysics, Vol. 433, Issue 1
  • DOI: 10.1016/j.abb.2004.09.018

Phosphite Dehydrogenase:  An Unusual Phosphoryl Transfer Reaction
journal, March 2001

  • Vrtis, Jennifer M.; White, Andrea K.; Metcalf, William W.
  • Journal of the American Chemical Society, Vol. 123, Issue 11
  • DOI: 10.1021/ja004301k

Identification of the Active Site Acid/Base Catalyst in a Bacterial Fumarate Reductase:  A Kinetic and Crystallographic Study
journal, September 2000

  • Doherty, Mary K.; Pealing, Sara L.; Miles, Caroline S.
  • Biochemistry, Vol. 39, Issue 35
  • DOI: 10.1021/bi000871l

Multiparametric scaling of diffraction intensities
journal, April 2003

  • Otwinowski, Zbyszek; Borek, Dominika; Majewski, Wladyslaw
  • Acta Crystallographica Section A Foundations of Crystallography, Vol. 59, Issue 3
  • DOI: 10.1107/S0108767303005488

Chemical Rescue by Guanidine Derivatives of an Arginine-Substituted Site-Directed Mutant of Escherichia coli Ornithine Transcarbamylase
journal, January 1996

  • Rynkiewicz, Michael J.; Seaton, Barbara A.
  • Biochemistry, Vol. 35, Issue 50
  • DOI: 10.1021/bi961311i

Cloning, Expression, and Characterization of a Wide-pH-Range Stable Phosphite Dehydrogenase from Pseudomonas sp. K in Escherichia coli
journal, January 2012

  • Liu, Dan-Feng; Ding, Hai-Tao; Du, Yi-Qing
  • Applied Biochemistry and Biotechnology, Vol. 166, Issue 5
  • DOI: 10.1007/s12010-011-9518-2

IMP dehydrogenase: structural schizophrenia and an unusual base
journal, October 2006


Phaser crystallographic software
journal, July 2007

  • McCoy, Airlie J.; Grosse-Kunstleve, Ralf W.; Adams, Paul D.
  • Journal of Applied Crystallography, Vol. 40, Issue 4
  • DOI: 10.1107/S0021889807021206

Purification and Characterization of a Novel Phosphorus-oxidizing Enzyme from Pseudomonas stutzeri WM88
journal, February 2001

  • Costas, Amaya M. Garcia; White, Andrea K.; Metcalf, William W.
  • Journal of Biological Chemistry, Vol. 276, Issue 20
  • DOI: 10.1074/jbc.M011764200

Crystal Structures of Phosphite Dehydrogenase Provide Insights into Nicotinamide Cofactor Regeneration
journal, May 2012

  • Zou, Yaozhong; Zhang, Houjin; Brunzelle, Joseph S.
  • Biochemistry, Vol. 51, Issue 21
  • DOI: 10.1021/bi2016926

Self-Sufficient Baeyer–Villiger Monooxygenases: Effective Coenzyme Regeneration for Biooxygenation by Fusion Engineering
journal, March 2008

  • Torres Pazmiño, Daniel E.; Snajdrova, Radka; Baas, Bert-Jan
  • Angewandte Chemie International Edition, Vol. 47, Issue 12
  • DOI: 10.1002/anie.200704630

Efficient Biooxidations Catalyzed by a New Generation of Self-Sufficient Baeyer-Villiger Monooxygenases
journal, November 2009

  • Torres Pazmiño, Daniel E.; Riebel, Anette; de Lange, Jon
  • ChemBioChem, Vol. 10, Issue 16
  • DOI: 10.1002/cbic.200900480