skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Structural basis for protein-RNA recognition in telomerase

Authors:
; ; ; ; ; ; ; ; ORCiD logo;
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Org.:
FOREIGN
OSTI Identifier:
1497125
Resource Type:
Journal Article
Journal Name:
Nature Structural & Molecular Biology
Additional Journal Information:
Journal Volume: 21; Journal Issue: 6; Journal ID: ISSN 1545-9993
Publisher:
Nature Publishing Group
Country of Publication:
United States
Language:
ENGLISH

Citation Formats

Huang, Jing, Brown, Andrew F., Wu, Jian, Xue, Jing, Bley, Christopher J., Rand, Dustin P., Wu, Lijie, Zhang, Rongguang, Chen, Julian J-L, and Lei, Ming. Structural basis for protein-RNA recognition in telomerase. United States: N. p., 2014. Web. doi:10.1038/nsmb.2819.
Huang, Jing, Brown, Andrew F., Wu, Jian, Xue, Jing, Bley, Christopher J., Rand, Dustin P., Wu, Lijie, Zhang, Rongguang, Chen, Julian J-L, & Lei, Ming. Structural basis for protein-RNA recognition in telomerase. United States. doi:10.1038/nsmb.2819.
Huang, Jing, Brown, Andrew F., Wu, Jian, Xue, Jing, Bley, Christopher J., Rand, Dustin P., Wu, Lijie, Zhang, Rongguang, Chen, Julian J-L, and Lei, Ming. Sun . "Structural basis for protein-RNA recognition in telomerase". United States. doi:10.1038/nsmb.2819.
@article{osti_1497125,
title = {Structural basis for protein-RNA recognition in telomerase},
author = {Huang, Jing and Brown, Andrew F. and Wu, Jian and Xue, Jing and Bley, Christopher J. and Rand, Dustin P. and Wu, Lijie and Zhang, Rongguang and Chen, Julian J-L and Lei, Ming},
abstractNote = {},
doi = {10.1038/nsmb.2819},
journal = {Nature Structural & Molecular Biology},
issn = {1545-9993},
number = 6,
volume = 21,
place = {United States},
year = {2014},
month = {5}
}

Works referenced in this record:

The Telomerase Database
journal, December 2007

  • Podlevsky, J. D.; Bley, C. J.; Omana, R. V.
  • Nucleic Acids Research, Vol. 36, Issue Database
  • DOI: 10.1093/nar/gkm700

RNA-protein binding interface in the telomerase ribonucleoprotein
journal, November 2011

  • Bley, C. J.; Qi, X.; Rand, D. P.
  • Proceedings of the National Academy of Sciences, Vol. 108, Issue 51
  • DOI: 10.1073/pnas.1100270108

A Box H/ACA Small Nucleolar RNA-Like Domain at the Human Telomerase RNA 3′ End
journal, January 1999

  • Mitchell, James R.; Cheng, Jeffrey; Collins, Kathleen
  • Molecular and Cellular Biology, Vol. 19, Issue 1
  • DOI: 10.1128/MCB.19.1.567

Human Telomerase Domain Interactions Capture DNA for TEN Domain-Dependent Processive Elongation
journal, May 2011


Association between aplastic anaemia and mutations in telomerase RNA
journal, June 2002


Effect of pseudouridylation on the structure and activity of the catalytically essential P6.1 hairpin in human telomerase RNA
journal, June 2010

  • Kim, Nak-Kyoon; Theimer, Carla A.; Mitchell, James R.
  • Nucleic Acids Research, Vol. 38, Issue 19
  • DOI: 10.1093/nar/gkq525

The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita
journal, September 2001

  • Vulliamy, Tom; Marrone, Anna; Goldman, Frederick
  • Nature, Vol. 413, Issue 6854
  • DOI: 10.1038/35096585

Telomerase therapeutics for cancer: challenges and new directions
journal, June 2006

  • Shay, Jerry W.; Wright, Woodring E.
  • Nature Reviews Drug Discovery, Vol. 5, Issue 7
  • DOI: 10.1038/nrd2081

Secondary Structure of Vertebrate Telomerase RNA
journal, March 2000


Structural basis for telomerase catalytic subunit TERT binding to RNA template and telomeric DNA
journal, March 2010

  • Mitchell, Meghan; Gillis, Andrew; Futahashi, Mizuko
  • Nature Structural & Molecular Biology, Vol. 17, Issue 4
  • DOI: 10.1038/nsmb.1777

Structure and sequence elements of the CR4/5 domain of medaka telomerase RNA important for telomerase function
journal, December 2013

  • Kim, Nak-Kyoon; Zhang, Qi; Feigon, Juli
  • Nucleic Acids Research, Vol. 42, Issue 5
  • DOI: 10.1093/nar/gkt1276

The common ancestral core of vertebrate and fungal telomerase RNAs
journal, October 2012

  • Qi, Xiaodong; Li, Yang; Honda, Shinji
  • Nucleic Acids Research, Vol. 41, Issue 1
  • DOI: 10.1093/nar/gks980

Features and development of Coot
journal, March 2010

  • Emsley, P.; Lohkamp, B.; Scott, W. G.
  • Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 4
  • DOI: 10.1107/S0907444910007493

The architecture of Tetrahymena telomerase holoenzyme
journal, April 2013

  • Jiang, Jiansen; Miracco, Edward J.; Hong, Kyungah
  • Nature, Vol. 496, Issue 7444
  • DOI: 10.1038/nature12062

A critical stem-loop structure in the CR4-CR5 domain of mammalian telomerase RNA
journal, January 2002


Structure of the Human Telomerase RNA Pseudoknot Reveals Conserved Tertiary Interactions Essential for Function
journal, March 2005


Engineering cis-telomerase RNAs that add telomeric repeats to themselves
journal, March 2010

  • Qiao, F.; Goodrich, K. J.; Cech, T. R.
  • Proceedings of the National Academy of Sciences, Vol. 107, Issue 11
  • DOI: 10.1073/pnas.0909366107

Telomerase RNA structure and function: implications for dyskeratosis congenita
journal, April 2004


PHENIX: a comprehensive Python-based system for macromolecular structure solution
journal, January 2010

  • Adams, Paul D.; Afonine, Pavel V.; Bunkóczi, Gábor
  • Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 2, p. 213-221
  • DOI: 10.1107/S0907444909052925

Pyrimidine motif triple helix in the Kluyveromyces lactis telomerase RNA pseudoknot is essential for function in vivo
journal, June 2013

  • Cash, D. D.; Cohen-Zontag, O.; Kim, N. -K.
  • Proceedings of the National Academy of Sciences, Vol. 110, Issue 27
  • DOI: 10.1073/pnas.1309590110

Beginning to Understand the End of the Chromosome
journal, January 2004


Telomerase and cancer therapeutics
journal, March 2008

  • Harley, Calvin B.
  • Nature Reviews Cancer, Vol. 8, Issue 3
  • DOI: 10.1038/nrc2275

A critical three-way junction is conserved in budding yeast and vertebrate telomerase RNAs
journal, September 2007

  • Brown, Yogev; Abraham, Mira; Pearl, Sivan
  • Nucleic Acids Research, Vol. 35, Issue 18
  • DOI: 10.1093/nar/gkm713

Telomeres and human disease: ageing, cancer and beyond
journal, August 2005

  • Blasco, Maria A.
  • Nature Reviews Genetics, Vol. 6, Issue 8
  • DOI: 10.1038/nrg1656

Stem-Loop IV of Tetrahymena Telomerase RNA Stimulates Processivity in trans
journal, July 2003


The Structure and Function of Telomerase Reverse Transcriptase
journal, June 2006


The solution structure of an essential stem-loop of human telomerase RNA
journal, May 2003


Triple-helix structure in telomerase RNA contributes to catalysis
journal, May 2008

  • Qiao, Feng; Cech, Thomas R.
  • Nature Structural & Molecular Biology, Vol. 15, Issue 6
  • DOI: 10.1038/nsmb.1420

A Motif in the Vertebrate Telomerase N-Terminal Linker of TERT Contributes to RNA Binding and Telomerase Activity and Processivity
journal, October 2013


Structure of the Tribolium castaneum telomerase catalytic subunit TERT
journal, August 2008

  • Gillis, Andrew J.; Schuller, Anthony P.; Skordalakes, Emmanuel
  • Nature, Vol. 455, Issue 7213
  • DOI: 10.1038/nature07283

Structurally conserved five nucleotide bulge determines the overall topology of the core domain of human telomerase RNA
journal, October 2010

  • Zhang, Q.; Kim, N. -K.; Peterson, R. D.
  • Proceedings of the National Academy of Sciences, Vol. 107, Issue 44
  • DOI: 10.1073/pnas.1013269107

Two Inactive Fragments of the Integral RNA Cooperate To Assemble Active Telomerase with the Human Protein Catalytic Subunit (hTERT) In Vitro
journal, September 1999

  • Tesmer, Valerie M.; Ford, Lance P.; Holt, Shawn E.
  • Molecular and Cellular Biology, Vol. 19, Issue 9
  • DOI: 10.1128/MCB.19.9.6207

Phaser crystallographic software
journal, July 2007

  • McCoy, Airlie J.; Grosse-Kunstleve, Ralf W.; Adams, Paul D.
  • Journal of Applied Crystallography, Vol. 40, Issue 4
  • DOI: 10.1107/S0021889807021206

Structure and Function of the Smallest Vertebrate Telomerase RNA from Teleost Fish
journal, November 2007

  • Xie, Mingyi; Mosig, Axel; Qi, Xiaodong
  • Journal of Biological Chemistry, Vol. 283, Issue 4
  • DOI: 10.1074/jbc.M708032200